(2-Phenylthio-aethyl)-hydrazin | 55459-98-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (2-Phenylthio-aethyl)-hydrazin
• 英文别名: [2-(phenylthio)ethyl]-hydrazine；2-Phenylsulfanylethylhydrazine
• CAS: 55459-98-8
• 化学式: C₈H₁₂N₂S
• 分子量: 168.263
• InChiKey: MDIGZDJIIFKZHR-UHFFFAOYSA-N

物化性质

• 沸点：
  120 °C(Press: 0.05 Torr)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  63.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-氯苯并恶唑 、 (2-Phenylthio-aethyl)-hydrazin 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 以57%的产率得到N-Benzooxazol-2-yl-N-(2-phenylsulfanyl-ethyl)-hydrazine
  参考文献：
  名称：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation

  摘要：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.

  DOI：

  10.1021/jm00117a010
• 作为产物：
  描述：

  苯基溴代乙基硫醚 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 (2-Phenylthio-aethyl)-hydrazin
  参考文献：
  名称：

  单胺氧化酶抑制剂。一系列取代的烷基肼的合成与评估。

  摘要：

  DOI：

  10.1021/jm00337a015

文献信息

• Novel heterocyclic compounds, method for preparing same and use thereof as medicines, in particular as antibacterial agents
  申请人：Aszodi Joseph

  公开号：US20050245505A1

  公开（公告）日：2005-11-03

  The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds, as well as their use as medicaments, in particular as anti-bacterial agents.

  这项发明涉及一般式(I)的新杂环化合物及其与碱或酸形成的盐： 该发明还涉及制备这些化合物的方法，以及它们作为药物的用途，特别是作为抗菌剂。
• Novel heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
  申请人：AVENTIS PHARMA S.A.

  公开号：US20040157826A1

  公开（公告）日：2004-08-12

  The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: 1 The invention also relates to a method for preparing these compounds, and to their use as medicaments, in particular as antibacterials and &bgr;-lactamase inhibitors.

  这项发明涉及一般式(I)的新异环化合物及其与碱或酸的盐：1。该发明还涉及制备这些化合物的方法，并将它们用作药物，特别是作为抗菌药物和β-内酰胺酶抑制剂。
• Produits intermédiaires dans la préparation de composés anti-bactériens
  申请人：NOVEXEL

  公开号：EP1798231A2

  公开（公告）日：2007-06-20

  L'invention concerne de nouveaux composés hétérocycliques intermédiaires dans la synthèse des composés de formule générale (I) et de leurs sels avec une base ou un acide : Les composés de formule (I) sont utiles comme médicaments, notamment comme anti-bactériens.

  这个发明涉及到一种新的杂环化合物，用于合成通式（I）化合物及其与碱或酸形成的盐的中间体：通式（I）化合物可用作药物，特别是作为抗菌药物。
• NOVEL HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTIBACTERIALS AND BETA-LACTAMASE INHIBITORS
  申请人：Lampilas Maxime

  公开号：US20090018329A1

  公开（公告）日：2009-01-15

  The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a method for preparing these compounds, and to their use as medicaments, in particular as antibacterials and β-lactamase inhibitors.

  该发明涉及一种新型杂环化合物，其通式为（I），以及它们与酸或碱的盐：该发明还涉及一种制备这些化合物的方法，并将其用作药物，特别是作为抗菌剂和β-内酰胺酶抑制剂。
• COMPOSES HETEROCYCLIQUES, LEUR PREPARATION ET LEUR UTILISATION COMME MEDICAMENTS, NOTAMMENT COMME ANTI-BACTERIENS
  申请人：NOVEXEL

  公开号：EP1399444B1

  公开（公告）日：2007-04-11