2-[(1-吡咯烷基)甲基]吡啶 | 60032-62-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-[(1-吡咯烷基)甲基]吡啶
• 英文名称: 2-[(1-Pyrrolidinyl)methyl]pyridine
• 英文别名: 2-(pyrrolidin-1-ylmethyl)pyridine；2-(1-pyrrolidinylmethyl)pyridine；2-pyrrolidin-1-ylmethyl-pyridine；2-(N-pyrrolidinomethyl)pyridine；2-Pyrrolidino-methyl-pyridin；1-(2-Picolyl)-pyrrolidin
• CAS: 60032-62-4
• 化学式: C₁₀H₁₄N₂
• 分子量: 162.235
• InChiKey: XLXANWGTOZKKAZ-UHFFFAOYSA-N

物化性质

• 沸点：
  106-108 °C(Press: 9 Torr)
• 密度：
  1.072±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(1-吡咯烷基)甲基]吡啶 在 β-环糊精 、 2-碘酰基苯甲酸 作用下， 以 水 为溶剂， 反应 9.0h， 以79%的产率得到2-(1H-吡咯-1-基甲基)吡啶
  参考文献：
  名称：

  o-Iodoxybenzoic acid (IBX): a versatile reagent for the synthesis of N-substituted pyrroles mediated by β-cyclodextrin in water

  摘要：

  o-Iodoxybenzoic acid (IBX), a very mild and efficient hypervalent iodine(V) reagent, aromatizes diversely substituted 1-benzylpyrrolidines and N-substituted L-proline analogues to the corresponding substituted pyrroles in good to excellent yields under mild conditions mediated by beta-cyclodextrin in water at room temperature. To the best of our knowledge, this is the first report on IBX, promoting complete aromatization leading to N-benzylpyrroles from the corresponding saturated five membered heterocyclic derivatives in water medium. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.06.077
• 作为产物：
  描述：

  2-溴吡啶 在 Eosin Y 、 溶剂黄146 作用下， 以 甲醇 、 水 、 乙腈 为溶剂， 反应 5.0h， 生成 2-[(1-吡咯烷基)甲基]吡啶
  参考文献：
  名称：

  曙红Y促进芳香砜的无金属氨基甲基化

  摘要：

  报道了杂环与有机染料的光催化氨甲基化。通过氨基甲基自由基形成的 C-C 键可以一步获得一系列功能化的杂环，而无需过渡金属。

  DOI：

  10.1002/chem.202102124

文献信息

• [EN] BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS<br/>[FR] COMPOSÉS BENZÈNESULFONAMIDES ET LEUR UTILISATION EN TANT QU'AGENTS THÉRAPEUTIQUES
  申请人：XENON PHARMACEUTICALS INC

  公开号：WO2017201468A1

  公开（公告）日：2017-11-23

  This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

  本发明涉及苯磺酰胺化合物，包括它们的立体异构体、对映异构体、互变异构体或其混合物；或用于治疗与电压门控钠通道相关的疾病或病症的药用可接受盐、溶剂化物或前药，例如癫痫。
• Demonstration of In Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents
  作者：Qinggeng Zhuang、Andrew J. Franjesevic、Thomas S. Corrigan、William H. Coldren、Rachel Dicken、Sydney Sillart、Ashley DeYong、Nathan Yoshino、Justin Smith、Stephanie Fabry、Keegan Fitzpatrick、Travis G. Blanton、Jojo Joseph、Ryan J. Yoder、Craig A. McElroy、Özlem Doğan Ekici、Christopher S. Callam、Christopher M. Hadad

  DOI：10.1021/acs.jmedchem.7b01620

  日期：2018.8.23

  reactivators of OP-inhibited AChE are no longer effective. Realkylation of aged AChE may provide a route to reversing aging. We designed and synthesized a library of quinone methide precursors (QMPs) as proposed realkylators of aged AChE. Our lead compound (C8) from an in vitro screen successfully resurrected 32.7 and 20.4% of the activity of methylphosphonate-aged and isopropyl phosphate-aged electric-eel AChE

  在有机磷（OP）神经毒剂抑制乙酰胆碱酯酶（AChE）之后，磷酸化丝氨酸的脱烷基反应会发生，称为老化。老化后，OP抑制的AChE的已知激活剂将不再有效。老化的AChE的重烷基化可能提供逆转老化的途径。我们设计和合成了醌甲基化物前体（QMP）库，作为老化的AChE的拟烷基化剂。4天后，我们通过体外筛选得到的先导化合物（C8）分别成功恢复了甲基膦酸酯老化和磷酸异丙酯老化电鳗AChE活性的32.7和20.4％。C8显示复活（从老化状态恢复到原始状态）和重新激活（从抑制状态恢复到原始状态）的属性。C8可以使甲基膦酸酯老化的AChE的复活显着依赖于pH，仅在1天后在4 mM和pH 9时恢复了21％的活性。C8对磷酸异丙酯老化的人AChE也有效。
• Condensed diazepinones, their compositions and methods of use as
  申请人：Dr. Karl Thomae GmbH

  公开号：US04550107A1

  公开（公告）日：1985-10-29

  Disclosed are novel condensed diazepinones of formula I ##STR1## wherein B is a fused ring selected from ##STR2## X is --CH-- or, when B is ortho-phenylene, X can also be nitrogen; A.sub.1 is C.sub.1 -C.sub.2 alkylene; A.sub.2 is C.sub.1 -C.sub.2 when it is in the 2-position relative to the saturated heterocyclic ring nitrogen or a single bond or methylene when it is in the 3- or 4-position; R.sub.1 is C.sub.1 -C.sub.3 alkyl; R.sub.2 is C.sub.1 -C.sub.7 alkyl, optionally hydroxy-substituted on at least one of its second to seventh carbon, or C.sub.3 -C.sub.7 cycloalkyl, optionally hydroxy substituted, or C.sub.3 -C.sub.7 cycloalkylmethyl; or R.sub.1 and R.sub.2 can, together with the nitrogen therebetween, be a 4- to 7-membered saturated monocyclic, heterocyclic ring which can optionally include an oxygen or N--CH.sub.3 ; R.sub.3 is hydrogen, chlorine, or methyl; R.sub.4 is hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.5 is hydrogen, chlorine or C.sub.1 -C.sub.4 alkyl; and Z is a single bond, oxygen, methylene or 1,2-ethylene; and NR.sub.1 R.sub.2 --N oxides and nontoxic, pharmaceutically acceptable addition salts thereof. Also disclosed are pyrrolobenzodiazepinone intermediates, pharmaceutical compositions containing the condensed diazepinones and methods of using them to treat cardiovascular disorders, particularly bradycardia and bradyarrhythmia.

  揭示了式I的新型缩合二氮杂环酮##STR1##其中B是从##STR2##中选择的融合环；X是--CH--或者当B是邻苯二甲烷时，X也可以是氮；A.sub.1是C.sub.1-C.sub.2烷基；A.sub.2是C.sub.1-C.sub.2，当它相对于饱和杂环环氮位于2位时，或者是单键或亚甲基，当它位于3位或4位时；R.sub.1是C.sub.1-C.sub.3烷基；R.sub.2是C.sub.1-C.sub.7烷基，其至少在第二到第七碳上可选择地被羟基取代，或者是C.sub.3-C.sub.7环烷基，可选择地被羟基取代，或者是C.sub.3-C.sub.7环烷基甲基；或者R.sub.1和R.sub.2可以与其之间的氮一起形成一个4到7成员的饱和单环杂环，可选择地包括氧或N--CH.sub.3；R.sub.3是氢、氯或甲基；R.sub.4是氢或C.sub.1-C.sub.4烷基，R.sub.5是氢、氯或C.sub.1-C.sub.4烷基；Z是单键、氧、亚甲基或1,2-乙烯基；以及NR.sub.1 R.sub.2 --N氧化物和其无毒、药学上可接受的加合盐。还揭示了吡咯苯二氮杂环酮中间体、含有缩合二氮杂环酮的药物组合物以及使用它们治疗心血管疾病，特别是心动过缓和心动过缓性心律失常的方法。
• BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION
  申请人：Sandanayaka Vincent

  公开号：US20070066820A1

  公开（公告）日：2007-03-22

  The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is

  这项发明涉及一种化学类别的双芳基取代杂环抑制剂，用于治疗、预防和预防炎症性疾病和紊乱。这些化合物具有一般公式Ψ：一个例子是
• <i>tert</i> -Butoxy-Radical-Promoted α-Arylation of Alkylamines with Aryl Halides
  作者：Ryota Ueno、Yuko Ikeda、Eiji Shirakawa

  DOI：10.1002/ejoc.201700548

  日期：2017.8.2

  In the presence of a tert-butoxy radical precursor, the reaction of alkylamines with aryl halides was found to give alpha-arylated alkylamines through homolytic aromatic substitution of the halogen atoms.

  在叔丁氧基自由基前体的存在下，发现烷基胺与芳基卤化物的反应通过卤素原子的均裂芳族取代得到α-芳基化烷基胺。