6-amino-N-methylanthrapyridone | 14642-72-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 6-amino-N-methylanthrapyridone
• 英文别名: 6-amino-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione；6-amino-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione；6-Amino-3-methyl-3H-naphtho[1,2,3-de]chinolin-2,7-dion；6-Amino-N-methyl-anthrapyridon；6-Amino-3-methylanthrapyridon；10-amino-14-methyl-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9,11,13(17)-heptaene-8,15-dione
• CAS: 14642-72-9
• 化学式: C₁₇H₁₂N₂O₂
• 分子量: 276.294
• InChiKey: KWULQQPKJVEXMY-UHFFFAOYSA-N

物化性质

• 熔点：
  304-306 °C
• 沸点：
  549.8±50.0 °C(Predicted)
• 密度：
  1.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  63.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  6-amino-N-methylanthrapyridone 在 乙酸铵 、 三氯氧磷 作用下， 以 甲醇 为溶剂， 反应 2.5h， 生成 6-Methylbenzpyrido<4,3,2-g,h>perimidin-7-one
  参考文献：
  名称：

  Synthesis of pyridonoanthrapyrimidines

  摘要：

  DOI：

  10.1007/bf00506977
• 作为产物：
  描述：

  1-氨基-4-(甲基氨基)蒽醌 在 sodium hydroxide 、 硫酸 作用下， 以 乙醇 为溶剂， 生成 6-amino-N-methylanthrapyridone
  参考文献：
  名称：

  Kazankov, M. V.; Ginodman, L. G.; Mustafina, M. Ya., Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, # 2, p. 306 - 313

  摘要：

  DOI：

文献信息

• Luminescent compounds
  申请人：Patsenker D. Leonid

  公开号：US20080076188A1

  公开（公告）日：2008-03-27

  Reporter compounds based on aromatic and heterocyclic compounds, including intermediates used to synthesize the reporter compounds, and methods of synthesizing and using the reporter compounds, where the reporter compounds generally have the structure: where at least one pair of adjacent substituents (R a , R b ), (R b , R c ), (R c , R d ), (R d , R e ), (R e , R f ), (R f , R a ) is either a substituted cyclic or polycyclic group; or at least one set of three substituents (R a , R b , R c ), (R b , R c , R d ), (R c , R d , R e ), (R d , R e , R f ), (R e , R f , R a ) is a substituted cyclic or polycyclic group.

  基于芳香和杂环化合物的报告化合物，包括用于合成报告化合物的中间体，以及合成和使用报告化合物的方法，其中报告化合物通常具有以下结构：至少有一对相邻的取代基（Ra，Rb），（Rb，Rc），（Rc，Rd），（Rd，Re），（Re，Rf），（Rf，Ra）中的一对要么是取代的环或多环基团；或者至少有一组三个取代基（Ra，Rb，Rc），（Rb，Rc，Rd），（Rc，Rd，Re），（Rd，Re，Rf），（Re，Rf，Ra）是取代的环或多环基团。
• RADIATION-SENSITIVE COLORED COMPOSITION, COLORED CURED FILM, COLOR FILTER AND METHOD OF PRODUCING THE SAME, SOLID-STATE IMAGING DEVICE, LIQUID CRYSTAL DISPLAY APPARATUS, AND METHOD OF PRODUCING DYE
  申请人：USHIJIMA Kenta

  公开号：US20120235099A1

  公开（公告）日：2012-09-20

  The object of the present invention is to provide a radiation-sensitive colored composition which can supress the generation of the contamination of the device. A radiation-sensitive colored composition including: (A) a dye containing of from 10 ppm to 1000 ppm of a halogen ion; (B) a polymerizable compound; and (C) a solvent.

  本发明的目的是提供一种辐射敏感的着色组合物，可以抑制器件的污染产生。一种辐射敏感的着色组合物，包括：（A）一种含有10 ppm至1000 ppm卤离子的染料；（B）一种可聚合化合物；和（C）一种溶剂。
• ANTHRAPYRIDONE COMPOUNDS
  申请人：Chauhan Yogendrasinh Bharatsinh

  公开号：US20080045634A1

  公开（公告）日：2008-02-21

  A compound of Formula (I): wherein R 3 is an aromatic functionality selected from the group consisting of Formula II and Formula III: and wherein R 1 , R 2 , R 5 , R 6 , R 7 , R 9 , and R 10 are independently selected from the group consisting of an aliphatic functionality having 1 to 6 carbon atoms, an aromatic functionality having 3 to 20 carbon atoms, a cycloaliphatic functionality having 3 to 20 carbon atoms, a hydroxy group, a halogen group, and a cyano group; R 4 is an aliphatic functionality having 1 to 6 carbon atoms; R 8 is an aliphatic functionality having 1 to 6 carbon atoms; “n” has a value of 0 to 4; “m” has a value of 0 to 2; “p” has a value of 0 to 2; “u” has a value of 0 to 2; “q” has a value of 0 to 3; “t” has a value of 0 to 4; and “r” has a value of 0 to 5.

  化合物的化学式为（I）： 其中，R3是从公式II和公式III组成的芳香官能团，R1、R2、R5、R6、R7、R9和R10是独立选择自具有1至6个碳原子的脂肪族官能团、具有3至20个碳原子的芳香族官能团、具有3至20个碳原子的环状脂肪族官能团、羟基、卤素基和氰基的官能团；R4是具有1至6个碳原子的脂肪族官能团；R8是具有1至6个碳原子的脂肪族官能团；“n”的值为0至4；“m”的值为0至2；“p”的值为0至2；“u”的值为0至2；“q”的值为0至3；“t”的值为0至4；“r”的值为0至5。
• LUMINESCENT COMPOUNDS
  申请人：SETA BioMedicals, LLC

  公开号：US20150268246A1

  公开（公告）日：2015-09-24

  Methods of performing assays with long lifetime compounds are disclosed. The long lifetime compounds have a lifetime of 4 ns or longer and relate to the structure: Linked reactive groups or conjugated substances may generally be located at R a , R b , or R c . Adjacent substituents R a and R b may form a substituted, 5- or 6-membered heterocyclic group with one ring nitrogen. R e and R f may both be H, R e may be a sulfo group, or adjacent substituents R e and R f may form a cyclic ring structure. The long lifetime compounds contain at least one sulfo group and at least one ionic group, reactive group, or conjugated substance.

  本发明公开了使用长寿命化合物进行测定的方法。这些长寿命化合物的寿命为4纳秒或更长，并与下列结构相关：反应性基团或共轭物质通常可以位于Ra、Rb或Rc处。相邻的取代基Ra和Rb可以形成带有一个环氮的取代的5-或6-成员杂环基团。Re和Rf都可以是H，Re可以是磺酰基，或者相邻的取代基Re和Rf可以形成一个环状结构。这些长寿命化合物包含至少一个磺酰基和至少一个离子基团、反应性基团或共轭物质。
• Identification of 3<i>H</i>-Naphtho[1,2,3-<i>de</i>]quinoline-2,7-diones as Inhibitors of Apoptosis Signal-Regulating Kinase 1 (ASK1)
  作者：Galyna P. Volynets、Maksym O. Chekanov、Anatoliy R. Synyugin、Andriy G. Golub、Oleksandr P. Kukharenko、Volodymyr G. Bdzhola、Sergiy M. Yarmoluk

  DOI：10.1021/jm200117h

  日期：2011.4.28

  Apoptosis signal-regulating kinase 1 (ASK1) has recently emerged as an attractive therapeutic target for the treatment of cardiac and neurodegenerative disorders. The selective inhibitors of ASK1 may become important compounds for the development of clinical agents. We have identified the ASK1 inhibitor among 3H-naphtho[1,2,3-de]quinoline-2,7-diones using receptor-based virtual screening. In vitro kinase assay revealed that ethyl 2,7-dioxo-2,7-dihydro-3H-naphtho [1,2,3-de]quinoline-1-carboxylate (NQDI-1) inhibited ASK1 with a K-i of 500 nM. The competitive character of inhibition is demonstrated in Lineweaver-Burk plots. In our preliminary selectivity study this compound exhibited strong specific inhibitory activity toward ASK1.