2-(4-Bromophenoxy)ethanimidamide hydrochloride | 67386-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-Bromophenoxy)ethanimidamide hydrochloride
• 英文别名: 2-(4-bromophenoxy)ethanimidamide;hydrochloride
• CAS: 67386-39-4
• 化学式: C8H10BrClN2O
• 分子量: 265.53
• InChiKey: QMCGBTTWYYBOGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.19
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  59.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-Bromophenoxy)ethanimidamide hydrochloride 、 乙酰乙酸乙酯 以87%的产率得到
  参考文献：
  名称：

  KRAMER M. S.; SAAKYAN A. G.; GARIBDZHANYAN B. T.; STEPANYAN G. M.; MIRZOY+, XIM.-FARMATSEVT. ZH., 1978, 12, HO 5, 73-78

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl 2-(4-bromophenoxy)ethanimidate;hydrochloride 、 氨 以65%的产率得到
  参考文献：
  名称：

  KRAMER M. S.; SAAKYAN A. G.; GARIBDZHANYAN B. T.; STEPANYAN G. M.; MIRZOY+, XIM.-FARMATSEVT. ZH., 1978, 12, HO 5, 73-78

  摘要：

  DOI：

文献信息

• FP-Pocket-Binding Effectors and Methods for Using the Same to Modulate Telomerase Activity
  申请人：Skordalakes Emmanuel

  公开号：US20100158798A1

  公开（公告）日：2010-06-24

  The present invention embraces compounds selected for interacting with the Fingers-Palm pocket of telomerase and use thereof for modulating the activity of telomerase and preventing or treating diseases or conditions associated with telomerase.
• Screening Method and Compounds for Modulating Telomerase Activity
  申请人：Skordalakes Emmanuel

  公开号：US20120309759A1

  公开（公告）日：2012-12-06

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
• SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY
  申请人：The Wistar Institute

  公开号：US20160067257A1

  公开（公告）日：2016-03-10

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
• US8518940B2
  申请人：——

  公开号：US8518940B2

  公开（公告）日：2013-08-27
• US9234230B2
  申请人：——

  公开号：US9234230B2

  公开（公告）日：2016-01-12