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((1R,2R)-1-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropan-2-yloxy)diphenylphosphine | 1312540-25-2

中文名称
——
中文别名
——
英文名称
((1R,2R)-1-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropan-2-yloxy)diphenylphosphine
英文别名
[(1R,2R)-1-(3,5-dimethylphenyl)sulfanyl-3-methoxy-1-phenylpropan-2-yl]oxy-diphenylphosphane
((1R,2R)-1-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropan-2-yloxy)diphenylphosphine化学式
CAS
1312540-25-2
化学式
C30H31O2PS
mdl
——
分子量
486.615
InChiKey
IBSFWBKVWKNUIG-LOYHVIPDSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    7.5
  • 重原子数:
    34
  • 可旋转键数:
    10
  • 环数:
    4.0
  • sp3杂化的碳原子比例:
    0.2
  • 拓扑面积:
    43.8
  • 氢给体数:
    0
  • 氢受体数:
    3

反应信息

  • 作为产物:
    参考文献:
    名称:
    Modular optimization of enantiopure epoxide-derived P,S-ligands for rhodium-catalyzed hydrogenation of dehydroamino acids
    摘要:
    The optimization of P,S-ligands derived from enantiopure (2S,3S)-phenylglycidol for asymmetric rhodium-catalyzed hydrogenation of dehydroamino esters is described. The exceptionally high modular character of the (25,3S)-phenylglycidol platform is demonstrated by systematic modification of the ether and thioether moieties, the skeletal aryl substituent and the stereo and regiochemistry of the ligands. An experimentally useful method for the monitoring of hydrogenation reactions is also described and used for obtaining relevant data of the catalytic systems studied. (C) 2011 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.tet.2011.04.050
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文献信息

  • Modular optimization of enantiopure epoxide-derived P,S-ligands for rhodium-catalyzed hydrogenation of dehydroamino acids
    作者:Xisco Caldentey、Xacobe C. Cambeiro、Miquel A. Pericàs
    DOI:10.1016/j.tet.2011.04.050
    日期:2011.6
    The optimization of P,S-ligands derived from enantiopure (2S,3S)-phenylglycidol for asymmetric rhodium-catalyzed hydrogenation of dehydroamino esters is described. The exceptionally high modular character of the (25,3S)-phenylglycidol platform is demonstrated by systematic modification of the ether and thioether moieties, the skeletal aryl substituent and the stereo and regiochemistry of the ligands. An experimentally useful method for the monitoring of hydrogenation reactions is also described and used for obtaining relevant data of the catalytic systems studied. (C) 2011 Elsevier Ltd. All rights reserved.
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