2,4-Ditert-butyl-1-(2-methylphenoxy)benzene | 1018853-64-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-Ditert-butyl-1-(2-methylphenoxy)benzene
• CAS: 1018853-64-9
• 化学式: C₂₁H₂₈O
• 分子量: 296.453
• InChiKey: CNQWLHUSZXHDAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-溴甲苯 、 2,4-二叔丁基苯酚 在 N-丁基咪唑 、 copper(l) chloride potassium carbonate 作用下， 以 十四烷 、 甲苯 为溶剂， 反应 16.0h， 以99%的产率得到2,4-Ditert-butyl-1-(2-methylphenoxy)benzene
  参考文献：
  名称：

  PROCESS FOR THE CATALYTIC SYNTHESIS OF DIARYL ETHERS

  摘要：

  描述了一种制备化学式为(I)Ar—O—Ar′的二芳基醚的过程  (I)其中Ar是芳基或取代芳基基团，Ar′是芳基、取代芳基、杂环芳基或取代杂环芳基基团，通过将化学式为(II)的芳基或化学式为(III)的芳氧盐  (II)Ar—OH   (III)其中Ar的含义与化学式(I)中相同，R为碱金属，与化学式(IV)的芳基或杂环芳基溴  (IV)Ar′—Br进行反应，其中Ar′的含义与化学式(I)中相同，其特征在于在铜(I)盐和1-取代咪唑作为催化剂体系的存在下进行反应。

  公开号：

  US20090143594A1

文献信息

• PROCESS FOR THE CATALYTIC SYNTHESIS OF DIARYL ETHERS
  申请人：Cotte Alain

  公开号：US20090143594A1

  公开（公告）日：2009-06-04

  Described is a process for preparing diaryl ethers of the formula (I) Ar—O—Ar′  (I) In which Ar is an aryl or substituted aryl group and Ar′ is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group, by reacting an aryl of formula (II) or a aryloxy salt of formula (III) Ar—OH   (II) Ar—OR   (III) In which Ar has the same meaning as in formula (I) and R is an alkali metal, with an aryl or heteroaryl bromide of formula (IV) Ar′—Br   (IV) In which Ar′ has the same meaning as in formula (I), characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.

  描述了一种制备化学式为(I)Ar—O—Ar′的二芳基醚的过程  (I)其中Ar是芳基或取代芳基基团，Ar′是芳基、取代芳基、杂环芳基或取代杂环芳基基团，通过将化学式为(II)的芳基或化学式为(III)的芳氧盐  (II)Ar—OH   (III)其中Ar的含义与化学式(I)中相同，R为碱金属，与化学式(IV)的芳基或杂环芳基溴  (IV)Ar′—Br进行反应，其中Ar′的含义与化学式(I)中相同，其特征在于在铜(I)盐和1-取代咪唑作为催化剂体系的存在下进行反应。
• Improved process for the catalytic synthesis of diaryl ethers
  申请人：Saltigo GmbH

  公开号：EP2065357A1

  公开（公告）日：2009-06-03

  Described is a process for preparing diaryl ethers of the formula (I)          Ar-O-Ar'     (I) In which Ar is an aryl or substituted aryl group and Ar' is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group, by reacting an aryl of formula (II) or a aryloxy salt of formula (III)          Ar-OH     (II)          Ar-OR     (III) In which Ar has the same meaning as in formula (I) and R is an alkali metal, with an aryl or heteroaryl bromide of formula (IV)          Ar'-Br     (IV) In which Ar' has the same meaning as in formula (I), characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.

  描述了一种制备式 (I) 的二芳基醚的工艺 Ar-O-Ar' (I) 其中 Ar 是芳基或取代芳基，Ar'是芳基、取代芳基、杂芳基或取代杂芳基、 使式（II）的芳基或式（III）的芳氧基盐反应 Ar-OH (II) Ar-OR (III) 其中 Ar 与式（I）中的含义相同，R 为碱金属、 与式 (IV) 的芳基或杂芳基溴化物反应 Ar'-Br (IV) 其中 Ar' 的含义与式（I）中的相同、 其特征在于该反应是在铜（I）盐和 1-取代咪唑作为催化剂体系存在下进行的。
• US8304550B2
  申请人：——

  公开号：US8304550B2

  公开（公告）日：2012-11-06
• Bio-inspired copper catalysts for the formation of diaryl ethers
  作者：Thomas Schareina、Alexander Zapf、Alain Cotté、Nikolaus Müller、Matthias Beller

  DOI：10.1016/j.tetlet.2008.01.036

  日期：2008.3

  Aryl bromides and phenols are coupled efficiently to the corresponding diaryl ethers in the presence of a practical Cu(I)/l-butylimidazole catalyst system. The convenient protocol is applied successfully to the synthesis of 16 different diaryl ethers in high yield and selectivity. (C) 2008 Elsevier Ltd. All rights reserved.