3-(2,3-dihydroxypropylthio)propionic acid | 185519-07-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(2,3-dihydroxypropylthio)propionic acid
• 英文别名: Dhp-OH；3-(2,3-Dihydroxypropylsulfanyl)propanoic acid
• CAS: 185519-07-7
• 化学式: C₆H₁₂O₄S
• 分子量: 180.225
• InChiKey: SYDKCCWRRIWVMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-溴丙酸 、 1-硫代甘油 在 三乙胺 作用下， 以 乙腈 为溶剂， 生成 3-(2,3-dihydroxypropylthio)propionic acid
  参考文献：
  名称：

  TLR2配体Pam2Cys的激动剂活性的结构要求

  摘要：

  合成脂肽已显示出作为引发细胞和体液免疫的疫苗策略的巨大潜力。使用的最有效的脂质部分之一是S- [2,3-双（棕榈酰氧基）丙基]半胱氨酸（Pam2Cys）。Pam2Cys通过参与Toll样受体2（TLR 2）结合并激活树突状细胞。在这项研究中，我们通过改变核心结构S的三个结构元素，研究了Pam2Cys激动剂活性的结构要求。-（2，3-二羟丙基）-半胱氨酸，即（1）半胱氨酸残基的α-氨基；（2）半胱氨酸残基的硫原子；和（3）2，3-二羟丙基部分。制备了四个新颖的​​Pam2Cys类似物，并将这些类似物中的每一个掺入疫苗构建物中并检查了免疫原性。我们的结果表明（1）脱氨性肽疫苗的效力受到的影响最小（2）硫原子被酰胺键取代会导致生物活性显着降低（3）脱氨性和同时用酰胺键取代硫会显着降低两种类似物的生物活性（4），其中硫原子被酰胺键取代，而该类似物含有1，3-二羟丙基部分显示出比含有2，3-二羟丙基

  DOI：

  10.1007/s00726-009-0463-0

文献信息

• Derivatives of 6,7-Dihydroxy-4-thiaheptonic acid and their use
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0638588A1

  公开（公告）日：1995-02-15

  A compound of the formula: wherein each of R¹ and R² is hydrogen or an aliphatic acyl group, each of R³ and R⁴ is hydrogen or a protecting group, X is an amino acid sequence consisting of 1 to 10 amino acid residues which may be protected, Y is an amino acid sequence consisting of 1 to 5 amino acids residues which may be protected, bounding at a terminal carboxyl group, or a salt thereof has an activity of remarkably improving hematopoietic disorder and is useful as an immuno-stimulating agent or an agent for treating thrombocytopenia.

  式中的化合物： 其中R¹和R²各自为氢或脂肪酰基，R³和R⁴各自为氢或保护基，X为由1至10个可被保护的氨基酸残基组成的氨基酸序列、Y 是由 1 至 5 个氨基酸残基组成的氨基酸序列，可被保护，与末端羧基结合，或其盐具有显著改善造血障碍的活性，可用作免疫刺激剂或治疗血小板减少症的药物。
• Thioglycerol derivatives
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0641776A2

  公开（公告）日：1995-03-08

  A compound represented by the formula: wherein R1 and R2 are the same or different, an acyl group; R3, R4, R6 and R7 are the same or different, hydrogen or an alkyl group; R5 is hydrogen, an alkyl group or a hydroxyl group which may optionally be protected, or R4 and R5 are combined to form a chemical bond; X is a carbonyl group or a sulfonyl group; Y is an amino acid sequence consisting of 1 to 7 amino acid residues which may optionally be protected and having optionally an intervening -SO2NH-; n is an integer of 0 to 2, or a salt thereof. The compound or salt thereof of the present invention possesses immunoenhancing activity and platelet reduction recovery activity, and can be used as a prophylactic/therapeutic agent for leukocytopenia in cancer chemotherapy or radiotherapy, as an immunoenhancing agent in bone marrow transplantation therapy and the treatment of osteomyelodysplasia and aplastic anemia, and as a prophylactic/therapeutic agent for thrombocytopenia.

  一种由式表示的化合物： 其中，R1和R2相同或不同，为酰基；R3、R4、R6和R7相同或不同，为氢或烷基；R5为氢、烷基或羟基，可选择被保护，或R4和R5结合形成化学键；X为羰基或磺酰基；Y为由1至7个氨基酸残基组成的氨基酸序列，可选择被保护，中间可选择有-SO2NH-；n为0至2的整数，或其盐。 本发明的化合物或其盐具有免疫增强活性和血小板减少恢复活性，可用作癌症化疗或放疗中白细胞减少症的预防/治疗剂、骨髓移植治疗和骨髓增生异常及再生障碍性贫血治疗中的免疫增强剂，以及血小板减少症的预防/治疗剂。
• INK COMPOSITION AND IMAGE FORMING METHOD
  申请人：FUJIFILM Corporation

  公开号：EP2692805A1

  公开（公告）日：2014-02-05

  An ink composition includes: a graft polymer having a graft main chain having at least one selected from the group consisting of a urethane structure and a urea structure, and a graft side chain including the following Structure Gs; a polymerizable compound; and a polymerization initiator, wherein the polymerizable compound comprises a monofunctional polymerizable compound, and a total content of the monofunctional polymerizable compound in the ink composition is 50% by mass or more with respect to a total content of the polymerizable compound, and wherein the Structure Gs comprises a structure having three or more repeating units, each of which is formed from an atomic group selected from the group consisting of a carbon atom, a hydrogen atom, an oxygen atom, a sulfur atom and a halogen atom, and in which an SP value of the repeating units is from 17 (MPa)1/2 to 20 (MPa)1/2.

  一种油墨组合物包括接枝聚合物，其接枝主链至少具有选自氨基甲酸酯结构和脲结构组成的组中的一种，接枝侧链包括以下结构 Gs； 可聚合化合物；和聚合引发剂，其中可聚合化合物包括单官能团可聚合化合物，且单官能团可聚合化合物在油墨组合物中的总含量为可聚合化合物总含量的 50%（质量百分比）或以上、其中结构 Gs 包括具有三个或更多重复单元的结构，每个重复单元由选自碳原子、氢原子、氧原子、硫原子和卤素原子的原子团构成，其中重复单元的 SP 值为 17 (MPa)1/2 至 20 (MPa)1/2。
• METHOD OF PREPARING LITHOGRAPHIC PRINTING PLATE
  申请人：Taguchi Yoshinori

  公开号：US20100081771A1

  公开（公告）日：2010-04-01

  A method for preparing a lithographic printing plate includes treating a lithographic printing plate precursor including a hydrophilic support and an image-forming layer containing the following (i) to (iii) with an aqueous solution having a buffering ability: (i) a binder polymer comprising a repeating unit having a structure represented by the following formula (1); (ii) an ethylenically unsaturated compound; and (iii) a polymerization initiator, P-L-(CO 2 H) n (1) wherein P represents a part constituting a main chain skeleton of the polymer, L represents an (n+1) valent connecting group, and n represents an integer of 1 or more.
• BRANCHED POLYMER AND ANTIFOULING COATING COMPOSITION COMPRISING THE POLYMER
  申请人：Dahling Marit

  公开号：US20100183540A1

  公开（公告）日：2010-07-22

  The invention relates to a branched silyl ester copolymer comprising repeating units of (A) one or more monomers containing one polymerisable ethylenically unsaturated bond, of which at least one monomer is containing silyl ester functionality, (B) one or more monomers containing two or more polymerisable ethylenically unsaturated bonds, and (C) one or more chain transfer agents. Furthermore, the invention relates to the use of said branched silyl ester copolymer as a component in an antifouling coating composition, as well as to an antifouling coating composition comprising said branched silyl ester copolymer and one or more other components.