2-[(2-氯苯基)甲基]苯酚 | 62706-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[(2-氯苯基)甲基]苯酚
• 英文名称: 2-(2-chloro-benzyl)-phenol
• 英文别名: 2-Hydroxy-1-(2-chlor-benzyl)-benzol；2-(2-Chlor-benzyl)-phenol；2-[(2-Chlorophenyl)methyl]phenol
• CAS: 62706-91-6
• 化学式: C₁₃H₁₁ClO
• 分子量: 218.683
• InChiKey: NZUJXMKYDYKHDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-[(2-氯苯基)甲基]苯酚 在 氯仿 、 氯 作用下， 生成 2,4-dichloro-6-(2-chloro-benzyl)-phenol
  参考文献：
  名称：

  Chloro Derivatives of Benzyl Phenols. II. Some Monochloro, Dichloro and Trichloro Derivatives of Ortho and Para Benzyl Phenols

  摘要：

  DOI：

  10.1021/ja01338a052
• 作为产物：
  描述：

  、 2-溴苯酚 在 2-双环己基膦-2',6'-二甲氧基联苯 、 palladium diacetate 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以82%的产率得到2-[(2-氯苯基)甲基]苯酚
  参考文献：
  名称：

  带有相对酸性质子的不饱和卤化物的钯和镍催化交叉偶联与有机锌试剂。

  摘要：

  多种多官能芳基，杂芳基，烷基和苄基锌试剂与带有酸性NH或OH质子的不饱和芳基卤化物偶合，使用Pd（OAc）2（1 mol％）和S-Phos（2 mol％）作为不需要保护基的催化剂。描述了类似的镍催化反应。还描述了有机锌化合物的相对动力学碱性及其对酸性质子的稳定性。

  DOI：

  10.1021/jo8015852

文献信息

• ANTI-CANCER TREATMENT OF PRESELECTED SUBJECTS AND SCREENING METHODS TO IDENTIFY SUSCEPTIBLE SUBJECTS
  申请人：TUDAG TU Dresden Aktiengesellschaft

  公开号：EP3578981B1

  公开（公告）日：2021-10-27
• Aqueous organic dispersions suitable for removing organic films and soils
  申请人：Ecolab Inc.

  公开号：US20030207782A1

  公开（公告）日：2003-11-06

  Hard floor finishes and other stubborn soils can be removed using an aqueous dispersion of an alkylene glycol phenyl ether solvent combined with an ether alcohol solvent/coupler. Each component is used at a concentration that result in the creation of a visible dispersed appearance of the aqueous dilute use solutions. We have found that the alkylene glycol phenyl ether, in combination with at least one ether alcohol coupler or solvent, interacts with the aqueous medium to surprisingly provide enhanced cleaning performances. Hard to remove soils such as highly crosslinked urethanes and acrylic materials can be solubilized and removed by the alcohol solvent dispersions of the invention. We have found that the alkylene phenyl ether solvent requires a specific coupler cosolvent for activity. Such activity can be enhanced by the presence of a second coupler cosolvent and the use of a specific class of nonionic surfactant materials.
• US4506103A
  申请人：——

  公开号：US4506103A

  公开（公告）日：1985-03-19
• US6583101B1
  申请人：——

  公开号：US6583101B1

  公开（公告）日：2003-06-24
• [EN] ANTI-CANCER TREATMENT OF PRESELECTED SUBJECTS AND SCREENING METHODS TO IDENTIFY SUSCEPTIBLE SUBJECTS<br/>[FR] TRAITEMENT ANTICANCÉREUX DE SUJETS PRÉSÉLECTIONNÉS ET PROCÉDÉS DE CRIBLAGE POUR IDENTIFIER DES SUJETS SENSIBLES
  申请人：UNIV DRESDEN TECH

  公开号：WO2019233779A1

  公开（公告）日：2019-12-12

  The invention provides methods of screening a subject for a proliferative disease risk factor which comprises detecting the presence or absence of target cells. The presence of target cells in the subject indicates the subject is at increased risk of developing a proliferative disease or recurrence of a previously treated proliferative disease and defines a new patient subgroup susceptible for treatment with selected anti-proliferative compounds. Methods of screening compounds for the treatment of proliferative diseases based on the presence of target cells and the expression of certain biomarkers by said target cells are also disclosed, along with appropriate compounds and their use in methods of treating such diseases.