1,4-Bis-chloromethyl-2,3-dimethoxy-5,6-dimethyl-benzene | 209911-11-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-Bis-chloromethyl-2,3-dimethoxy-5,6-dimethyl-benzene
• 英文别名: 1,4-Bis(chloromethyl)-2,3-dimethoxy-5,6-dimethylbenzene
• CAS: 209911-11-5
• 化学式: C₁₂H₁₆Cl₂O₂
• 分子量: 263.164
• InChiKey: CFMNVGWPOPFFPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-Bis-chloromethyl-2,3-dimethoxy-5,6-dimethyl-benzene 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 3,6-Bis-chloromethyl-4,5-dimethyl-benzene-1,2-diol
  参考文献：
  名称：

  A facile synthesis of functionalized catechols

  摘要：

  A general route to functionalized catechols is achieved by the reaction of 3,6-di(chloromethyl)-4,5-dimethyl-catechol with various nucleophiles in the presence of a base. The reactions are proposed to occur by way of a dehydrochlorinated intermediate which undergoes Michael additions to give the catechol products. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00793-x
• 作为产物：
  描述：

  3,4-二甲氧基甲苯 在 lithium aluminium tetrahydride 、 硫酸 、 溶剂黄146 作用下， 反应 12.0h， 生成 1,4-Bis-chloromethyl-2,3-dimethoxy-5,6-dimethyl-benzene
  参考文献：
  名称：

  A facile synthesis of functionalized catechols

  摘要：

  A general route to functionalized catechols is achieved by the reaction of 3,6-di(chloromethyl)-4,5-dimethyl-catechol with various nucleophiles in the presence of a base. The reactions are proposed to occur by way of a dehydrochlorinated intermediate which undergoes Michael additions to give the catechol products. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00793-x

文献信息

• A facile synthesis of functionalized catechols
  作者：Chaozhong Li、Robert J. angelici

  DOI：10.1016/s0040-4039(98)00793-x

  日期：1998.6

  A general route to functionalized catechols is achieved by the reaction of 3,6-di(chloromethyl)-4,5-dimethyl-catechol with various nucleophiles in the presence of a base. The reactions are proposed to occur by way of a dehydrochlorinated intermediate which undergoes Michael additions to give the catechol products. (C) 1998 Elsevier Science Ltd. All rights reserved.