N,N-dimethyl-4-(propa-1,2-dien-1-yl)aniline | 86448-32-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dimethyl-4-(propa-1,2-dien-1-yl)aniline
• CAS: 86448-32-0
• 化学式: C₁₁H₁₃N
• 分子量: 159.231
• InChiKey: JTUPUASWSCXZGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  二苯基甲烷硫酮 、 N,N-dimethyl-4-(propa-1,2-dien-1-yl)aniline 生成 N,N-dimethyl-4-(4-methylidene-2,2-diphenylthietan-3-yl)aniline
  参考文献：
  名称：

  KAMPHUIS, J.;GROOTENHUIS, P. D. J.;BOSS, H. J. T., TETRAHEDRON LETT., 1983, 24, N 10, 1101-1104

  摘要：

  DOI：
• 作为产物：
  描述：

  对二甲氨基苯甲醛 在 copper(l) iodide 、 lithium tert-butoxide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 60.0~90.0 ℃ 、101.33 kPa 条件下， 生成 N,N-dimethyl-4-(propa-1,2-dien-1-yl)aniline
  参考文献：
  名称：

  Synthesis of Terminal Allenes through Copper-Mediated Cross-Coupling of Ethyne withN-Tosylhydrazones or α-Diazoesters

  摘要：

  Ethyne is employed as coupling partner in copper-mediated cross-coupling reactions with N-tosylhydrazones and alpha-diazoacetate, leading to the development of a new synthetic method for terminal allenes. With this novel coupling method, the terminal allenes were obtained in good yields and with excellent functional group tolerance. Copper carbene migratory insertion is proposed as the key step in these transformations.

  DOI：

  10.1021/jo502316q

文献信息

• Organomagnesium-Catalyzed Isomerization of Terminal Alkynes to Allenes and Internal Alkynes
  作者：Raphaël Rochat、Koji Yamamoto、Michael J. Lopez、Haruki Nagae、Hayato Tsurugi、Kazushi Mashima

  DOI：10.1002/chem.201500179

  日期：2015.5.26

  the transformation of these terminal alkynes into allenes and further to internal alkynes under mild conditions. To the best of our knowledge, this example is the first of an organomagnesium‐catalyzed isomerization of alkynes. Notably, the reactions proceeded through temporally separated autotandem catalysis, thus allowing the isolation of the allene or internal alkyne species in good yields. Mechanistic

  通过N，N-二烷基胺亚胺配体1和二苄基镁的亚胺部分的苄基化反应合成有机镁络合物2。3-芳基-1-丙炔与2反应形成相应的四炔基络合物，在温和条件下，这些络合物可作为催化剂将这些末端炔烃转化为丙二烯，并进一步转化为内部炔烃。据我们所知，该实例是炔烃有机镁催化异构化的第一个实例。值得注意的是，反应通过暂时分离的自动串联催化进行，从而允许以高收率分离出烯丙基或内部炔烃。机理实验表明，具有催化活性的四炔基络合物由炔基镁，烯丙基镁和炔丙基镁物种的互变异构混合物组成。
• Nitrogen and Sulfur-Containing Heterocycle Derivatives
  申请人：Armilli Murty N.

  公开号：US20110269953A1

  公开（公告）日：2011-11-03

  The present invention provides nitrogen and sulfur-containing heterocycle compounds to be used as scaffolds and, in particular, nitrogen and sulfur-containing heterocycle compounds having a thiomorpholine core. The compounds herein described may be useful in treating diseases such as diabetes, obesity, cancer, cardiovascular, Alzheimer's, inflammatory, antidepressant, rheumatoid arthritis, multiple sclerosis, allergic rhinitis, asthma as well as viral and bacterial infections. The compounds herein described may also be useful in treating CNS disorders such as but not limited to Schizophrenia, Alzheimer's disease (AD).

  本发明提供了氮和硫含杂环化合物，用作支架，特别是具有硫代吗啉核心的氮和硫含杂环化合物。所述化合物可用于治疗糖尿病、肥胖症、癌症、心血管疾病、阿尔茨海默病、炎症、抗抑郁症、类风湿性关节炎、多发性硬化症、过敏性鼻炎、哮喘以及病毒和细菌感染等疾病。所述化合物还可用于治疗中枢神经系统疾病，例如但不限于精神分裂症、阿尔茨海默病（AD）。
• Synthesis of Terminal Allenes through Copper-Mediated Cross-Coupling of Ethyne with<i>N</i>-Tosylhydrazones or α-Diazoesters
  作者：Fei Ye、Chengpeng Wang、Xiaoshen Ma、Mohammad Lokman Hossain、Ying Xia、Yan Zhang、Jianbo Wang

  DOI：10.1021/jo502316q

  日期：2015.1.2

  Ethyne is employed as coupling partner in copper-mediated cross-coupling reactions with N-tosylhydrazones and alpha-diazoacetate, leading to the development of a new synthetic method for terminal allenes. With this novel coupling method, the terminal allenes were obtained in good yields and with excellent functional group tolerance. Copper carbene migratory insertion is proposed as the key step in these transformations.
• KAMPHUIS, J.;GROOTENHUIS, P. D. J.;BOSS, H. J. T., TETRAHEDRON LETT., 1983, 24, N 10, 1101-1104
  作者：KAMPHUIS, J.、GROOTENHUIS, P. D. J.、BOSS, H. J. T.

  DOI：——

  日期：——