2-[(4-甲基苯氧基)甲基]苯胺 | 806596-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-[(4-甲基苯氧基)甲基]苯胺
• 英文名称: 4-methylphenyl 2-aminobenzyl ether
• 英文别名: 2-p-tolyloxymethyl-aniline；2-p-Tolyloxymethyl-anilin；2-[(4-Methylphenoxy)methyl]aniline
• CAS: 806596-41-8
• 化学式: C₁₄H₁₅NO
• mdl: MFCD09816325
• 分子量: 213.279
• InChiKey: QHRPZBMYSAPAEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(4-甲基苯氧基)甲基]苯胺 在 盐酸 、 permanganate(VII) ion 、 铜 、 sodium nitrite 作用下， 生成 2-methyl-6H-benzo[c]chromen-6-one
  参考文献：
  名称：

  Cavill et al., Journal of the Chemical Society, 1958, p. 1544,1548

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium polysulfide 作用下， 生成 2-[(4-甲基苯氧基)甲基]苯胺
  参考文献：
  名称：

  Cavill et al., Journal of the Chemical Society, 1958, p. 1544,1548

  摘要：

  DOI：

文献信息

• Synthesis of substituted 6H-benzo[c]chromenes: a palladium promoted ring closure of diazonium tetrafluoroborates
  作者：Jing Zhou、Liang-Zhu Huang、You-Qiang Li、Zhen-Ting Du

  DOI：10.1016/j.tetlet.2012.10.038

  日期：2012.12

  A highly efficient palladium-catalysed phenyl diazonium tetrafluoroborate participation of C-H activation ring closure protocol has been developed. A series of 6H-benzo[c]chromenes have been synthesized by intramolecular cyclization of ortho diazonium salts tetrafluoroborate of benzyloxyphenyl (Method A), or phenoxymethyl phenyl (Method B). The transformation allows the synthesis of 6H-benzo[c]chromenes with a wide variety of functional groups and substitution patterns from simple and easily accessible precursors. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.
• Chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers catalyzed by palladium–nickel bimetallic nanoparticles
  作者：Wenwen Chen、Hailin Bao、Dingsheng Wang、Xinyan Wang、Yadong Li、Yuefei Hu

  DOI：10.1016/j.tet.2015.10.037

  日期：2015.12

  A highly efficient and chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers was developed by using a novel palladium nickel bimetallic nanocatalyst. Since the catalytic selectivity was resulted from the synergistic effects between two metals rather than the traditional catalyst poisons, the hydrogenation proceeded smoothly under additive-free conditions. Thus, the work-up procedure was as simple as to recover the catalyst by a magnetic separation and then to evaporate the solvent. (C) 2015 Elsevier Ltd. All rights reserved.
• [EN] INHIBITORS OF HIV REPLICATION<br/>[FR] INHIBITEURS DE LA RÉPLICATION DU VIH
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2011143772A1

  公开（公告）日：2011-11-24

  Compounds of formula (I) wherein R1, R2, n and R3 are defined herein, are useful as inhibitors of HIV replication.
• Cavill et al., Journal of the Chemical Society, 1958, p. 1544,1548
  作者：Cavill et al.

  DOI：——

  日期：——