(R)-6,6'dimethoxybiphenyl-2,2'-bisphosphine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-6,6'dimethoxybiphenyl-2,2'-bisphosphine
• 英文别名: [3-Methoxy-2-(2-methoxy-6-phosphanylphenyl)phenyl]phosphane
• 化学式: C₁₄H₁₆O₂P₂
• 分子量: 278.227
• InChiKey: GTTDREDMUVHXSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-碘苯甲酸 、 (R)-6,6'dimethoxybiphenyl-2,2'-bisphosphine 在 1,1'-双(二苯基膦)二茂铁 、 palladium diacetate 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 以70%的产率得到(R)-6,6'-dimethoxy-P2,P2,P2',P2'-tetrakis-[4-(carbonyloxy)phenyl]biphenyl-2,2'-bisphosphine
  参考文献：
  名称：

  Efficient Route to Atropisomeric Ligands – Application to the Synthesis of MeOBIPHEP Analogues

  摘要：

  A highly efficient Pd-catalyzed P-C coupling reaction of easily accessible atropisomeric bisphosphane is described in the presence of various electron-poor aromatic iodides. The reactions are conducted in the presence of a Pd(II)/dppf catalyst in acetonitrile at 80 degrees C. The reaction conditions are compatible with several electron-withdrawing groups such as esters, cyano, chloro, and trifluoromethyl groups and lead to atropisomeric MeOBIPHEP derivatives in good to excellent yields and high enantiomeric purities.

  DOI：

  10.1021/ol2011874

文献信息

• Asymmetric hydrogenation of 1,1,1- trifluoroacetone
  申请人：Puentener Kurt

  公开号：US20080027249A1

  公开（公告）日：2008-01-31

  The invention relates to the preparation of enantiomerically pure (S)-1,1,1-trifluoro-2-propanol by asymmetric hydrogenation of 1,1,1-trifluoroacetone which process comprises hydrogenating 1,1,1-trifluoroacetone in the presence of a ruthenium phosphine complex catalyst represented by formula Ru(E)(E)(L)(A) wherein E, E′ are both chloro or E is hydrogen and E′ is BH 4 ; L is a chiral diphosphine ligand; and A is an optionally chiral diamine wherein hydrogenation occurs in the presence of a weak base, with or without an additive, when E and E′ are both chloro or b) in the absence of a base and an additive when E and E′ are hydrogen and BH 4 .

  该发明涉及通过不对称氢化1,1,1-三氟乙酮来制备对映纯的(S)-1,1,1-三氟-2-丙醇的方法，该过程包括在存在以Ru(E)(E)(L)(A)为表示的钌膦配合物催化剂下氢化1,1,1-三氟乙酮，其中E，E′均为氯或E为氢，E′为BH4；L为手性双膦配体；A为可选择手性二胺，在E和E′均为氯或b）时，在弱碱的存在下进行氢化，有无添加剂均可，当E和E′均为氢和 时，在无碱和添加剂的情况下进行氢化。
• PROCESSES FOR THE PREPARATION OF PERIPHERAL OPIOID ANTAGONIST COMPOUNDS AND INTERMEDIATES THERETO
  申请人：Dolle Roland E.

  公开号：US20150045556A1

  公开（公告）日：2015-02-12

  Novel processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto. The compounds prepared by the present processes may be useful, for example, as antagonists to the mu, kappa and delta opioid receptors, and thereby may be useful in the treatment of gastrointestinal motility disorders, and in preventing peripheral opiate induced side effects. The present processes may offer improved yields, chemical or stereochemical purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.

  该专利介绍了一种制备周围性阿片受体拮抗剂化合物及其中间体的新工艺。该工艺所制备的化合物可以作为mu、kappa和delta阿片受体的拮抗剂，因此可以用于治疗胃肠运动障碍，并预防周围性阿片类药物引起的副作用。该工艺可能提供更高的产率、化学或立体化学纯度、中间体和最终产品易于制备和分离，以及更具工业应用性的反应条件和可操作性。
• METHOD FOR PRODUCING OPTICALLY ACTIVE FLUORINE-CONTAINING OXETEN
  申请人：Tokyo Institute of Technology

  公开号：EP2644605B1

  公开（公告）日：2016-04-06
• NOVEL COMPOUND, NOVEL LIGAND, NOVEL TRANSITION METAL COMPLEXES, AND CATALYSTS CONSISTING OF NOVEL TRANSITION METAL COMPLEXES
  申请人：National University Corporation Okayama University

  公开号：EP2676963B1

  公开（公告）日：2016-08-24
• SELECTIVE HYDROGENATION OF ALDEHYDES WITH RU/BIDENTATE LIGANDS COMPLEXES
  申请人：Firmenich SA

  公开号：EP2970067B1

  公开（公告）日：2017-08-16