2-[(氯甲基)硫基]嘧啶 | 19834-93-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 2-[(氯甲基)硫基]嘧啶
• 英文名称: chloro(pyrimidin-2-ylthio)methane
• 英文别名: 2-chloromethylsulfanyl-pyrimidine；2--pyrimidin；2-pyrimidin；2-((Chloromethyl)thio)pyrimidine；2-(chloromethylsulfanyl)pyrimidine
• CAS: 19834-93-6
• 化学式: C₅H₅ClN₂S
• 分子量: 160.627
• InChiKey: RFJFZILWLCPSIX-UHFFFAOYSA-N

物化性质

• 熔点：
  47.7-48.1 °C
• 沸点：
  239.3±23.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-巯基嘧啶 以85%的产率得到2-chloromethylsulfanyl-pyrimidin-4-ylamine
  参考文献：
  名称：

  NOVEL CEPHALOSPORIN COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND ANTIMICROBIAL COMPOSITIONS CONTAINING THE SAME

  摘要：

  公开号：

  EP1077981B1

文献信息

• NEW AZABENZIMIDAZOLE DERIVATIVES
  申请人：HIMMELSBACH Frank

  公开号：US20150025065A1

  公开（公告）日：2015-01-22

  The present invention relates to compounds of general formula I, wherein the group R 1 , R 2 , X and Y are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

  本发明涉及一般式I的化合物，其中基团R1、R2、X和Y的定义如权利要求1中所述，具有有价值的药理特性，特别是与AMP-活化蛋白激酶（AMPK）结合并调节其活性。这些化合物适用于治疗和预防受该受体影响的疾病，如代谢性疾病，特别是2型糖尿病。
• [EN] NOVEL CEPHALOSPORIN COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND ANTIMICROBIAL COMPOSITIONS CONTAINING THE SAME<br/>[FR] NOUVEAUX COMPOSES DE CEPHALOSPORINE, PROCEDES DE PREPARATION DESDITS COMPOSES ET COMPOSITIONS ANTIMICROBIENNES CONTENANT CES COMPOSES
  申请人：LG CHEMICAL LTD.

  公开号：WO1999058535A1

  公开（公告）日：1999-11-18

  (EN) This invention relates to novel cephalosporin compounds of formula (I), wherein A, R1, R2, Q and B are each as defined in the specification, processes for preparation thereof and antimicrobial compositions containing the same.(FR) L'invention concerne de nouveaux composés de céphalosporine de la formule (I), dans laquelle A, R1, R2, Q et B sont, chacun, tels que définis dans le mémorandum descriptif. L'invention concerne également des procédés de préparation desdits composés et des compositions antimicrobiennes contenant ces composés.

  该发明涉及公式(I)的新型头孢菌素化合物，其中A、R1、R2、Q和B在说明书中各自定义，以及制备这些化合物的工艺和含有它们的抗微生物组合物。
• Stereoselective glycosylation using fully benzylated pyrimidin-2-yl 1-thio-β-d-glycopyranosides
  作者：Qian Chen、Fanzuo Kong

  DOI：10.1016/0008-6215(95)00031-n

  日期：1995.8

  Pyrimidin-2-yl 2,3,4,6-tetra-O-benzyl-1-thio-beta-D-gluco- (5) and -beta-D-galacto-pyranoside (6), and pyrimidin-2-yl 2,3,4-tri-O-benzyl-1-thio-beta-D-xylo- (7), and -alpha-D-arabino-pyranoside (8) were readily prepared from the corresponding per-O-acetylated 1-thioglycopyranosides, which were in turn obtained from the relevant acetobromosugars and 2-mercaptopyrimidine under phase-transfer conditions. Glycosidic coupling reactions using 5 (or 6, 7, or 8) as the donor and methyl 2,4,6-tri-O-benzyl-alpha-D-mannopyranoside as the acceptor in the presence of trimethylsilyl triflate afforded 1,2-cis-configured, 1 --> 3-linked disaccharides (alpha from 5, 6, and 7, beta from 8) as the sole products in moderate to excellent yields. The coupling reaction of 6 (or 7 or 8) with 1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose in the presence of silver triflate furnished 1 --> 6-linked disaccharides in high yield, with the 1,2-cis isomers predominant.
• GORALSKI C. T.; BURK G. A., J. ORG. CHEM. <JOCE-AH>, 1977, 42, NO 18, 3094-3096
  作者：GORALSKI C. T.、 BURK G. A.

  DOI：——

  日期：——
• US9492436B2
  申请人：——

  公开号：US9492436B2

  公开（公告）日：2016-11-15