1,5-bis(p-methylphenyl)-3-phenylformazan | 56156-42-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,5-bis(p-methylphenyl)-3-phenylformazan
• 英文别名: 1,5-di-p-tolyl-3-phenylformazan
• CAS: 56156-42-4
• 化学式: C₂₁H₂₀N₄
• 分子量: 328.417
• InChiKey: PZISOKZWPDKAKI-WQQFVFIJSA-N

物化性质

• 沸点：
  474.8±48.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.86
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  49.11
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 1,5-bis(p-methylphenyl)-3-phenylformazan 在 sodium hydroxide 、 氧气 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以50.2%的产率得到3-phenyl-1,5-di-p-tolylverdazyl
  参考文献：
  名称：

  Electrochemical Studies of Verdazyl Radicals

  摘要：

  The redox properties of verdazyl radicals are presented using cyclic voltammetry techniques. These radicals can be reversibly reduced as well as oxidized. Electron-donating and -withdrawing substituents have significant effects on the oxidation and reduction potentials as well as the cell potential (E-cell = |E-ox(degrees) - E-red(degrees)|) for these radicals; a correlation between the electron spin distribution and redox properties is developed.

  DOI：

  10.1021/ol702163a
• 作为产物：
  描述：

  苯丙酮酸 、 乙烷,三氯氟- 在 盐酸 、 sodium hydroxide 、 sodium nitrite 作用下， 生成 1,5-bis(p-methylphenyl)-3-phenylformazan
  参考文献：
  名称：

  丙酮酸衍生物的新合成大环冠-甲醛

  摘要：

  通过适当的双重氮盐4a-c与丙酮酸和芳基丙酮酸8a-c的偶氮偶联来制备大环冠-甲氮杂7a-c，12a-g。后者的容易获得的性质提供了对1，5-对称的双取代的3-芳基甲氮烷（例如10a-g）及其预期有价值的应用的大环冠衍生物的容易获得。

  DOI：

  10.1016/s0040-4020(01)89286-3

文献信息

• Formazans as β-diketiminate analogues. Structural characterization of boratatetrazines and their reduction to borataverdazyl radical anions
  作者：Joe B. Gilroy、Michael J. Ferguson、Robert McDonald、Brian O. Patrick、Robin G. Hicks

  DOI：10.1039/b609365e

  日期：——

  Formazans react with boron triacetate to produce boratatetrazines, which can be reduced to yield borataverdazyl radical anions—the first boron containing verdazyl radicals.

  福尔马赞与三乙酸硼反应生成硼酚四嗪，这些化合物可以被还原生成含硼的维尔达氮自由基阴离子——第一种含硼的维尔达氮自由基。
• MCCONNACHIE G.; NEUGEBAUER F. A., TETRAHEDRON <TETR-AB>, 1975, 31, NO 6, 555-560
  作者：MCCONNACHIE G.、 NEUGEBAUER F. A.

  DOI：——

  日期：——
• COMPOSITION AND METHOD FOR TREATING CANCER
  申请人：CELLWORKS GROUP, INC.

  公开号：US20160058751A1

  公开（公告）日：2016-03-03

  The present disclosure relates to a pharmaceutical composition and a kit to treat cancer. The disclosure provides a combination of compounds for use in the treatment of cancer. The disclosure further provides a process of preparing the composition and a method of treating a cancer associated with a RAS mutation or a RAS mutation along with any other mutation.
• New synthesis of macrocyclic crown-formazans from pyruvic acid derivatives
  作者：Yehia A. Ibrahim、Ahmed H.M. Elwahy、Ashraf A. Abbas

  DOI：10.1016/s0040-4020(01)89286-3

  日期：1994.1

  7a-c, 12a-g were prepared by the azo coupling of the appropriate bis-diazonium salts 4a-c with pyruvic acid and arylpyruvic acids 8a-c. The ready accessability of the latters offers an easy access towards 1,5- symmetrically disubstituted-3-arylformazans e.g. 10a-g as well as their macrocyclic crown derivatives of expected valuable applications.

  通过适当的双重氮盐4a-c与丙酮酸和芳基丙酮酸8a-c的偶氮偶联来制备大环冠-甲氮杂7a-c，12a-g。后者的容易获得的性质提供了对1，5-对称的双取代的3-芳基甲氮烷（例如10a-g）及其预期有价值的应用的大环冠衍生物的容易获得。
• Electrochemical Studies of Verdazyl Radicals
  作者：Joe B. Gilroy、Stephen D. J. McKinnon、Bryan D. Koivisto、Robin G. Hicks

  DOI：10.1021/ol702163a

  日期：2007.11.1

  The redox properties of verdazyl radicals are presented using cyclic voltammetry techniques. These radicals can be reversibly reduced as well as oxidized. Electron-donating and -withdrawing substituents have significant effects on the oxidation and reduction potentials as well as the cell potential (E-cell = |E-ox(degrees) - E-red(degrees)|) for these radicals; a correlation between the electron spin distribution and redox properties is developed.