2-hydrazino-naphth[1,2-d]oxazole | 66622-32-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-hydrazino-naphth[1,2-d]oxazole
• 英文别名: 2-Hydrazino-naphth[1,2-d]oxazol；Benzo[e][1,3]benzoxazol-2-ylhydrazine
• CAS: 66622-32-0
• 化学式: C₁₁H₉N₃O
• 分子量: 199.212
• InChiKey: NTFSZCDIGYXUED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-hydrazino-naphth[1,2-d]oxazole 、 丙烯腈 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 3-[1-(1,2-naphthoxazol-2-yl)hydrazino]propanenitrile
  参考文献：
  名称：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation

  摘要：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.

  DOI：

  10.1021/jm00117a010
• 作为产物：
  描述：

  2-chloro-3-oxa-1-aza-cyclopenta[a]naphthalene 在 一水合肼 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-hydrazino-naphth[1,2-d]oxazole
  参考文献：
  名称：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation

  摘要：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.

  DOI：

  10.1021/jm00117a010

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Fe: Org.Verb.A4, 5.1.4.7.2.5, page 266 - 270
  作者：

  DOI：——

  日期：——
• DE614327
  申请人：——

  公开号：——

  公开（公告）日：——
• Heterocyclic hydrazines
  申请人：IG FARBENINDUSTRIE AG

  公开号：US02073600A1

  公开（公告）日：1937-03-16
• Kharchuk, V. G.; Petrov, L. A., Zhurnal Obshchei Khimii, 1978, vol. 48, p. 418 - 419
  作者：Kharchuk, V. G.、Petrov, L. A.

  DOI：——

  日期：——
• HAVIV, FORTUNA;RATAJCZYK, JAMES D.;DENET, ROBERT W.;KERDESKY, FRANCIS A.;+, J. MED. CHEM., 31,(1988) N 9, C. 1719-1728
  作者：HAVIV, FORTUNA、RATAJCZYK, JAMES D.、DENET, ROBERT W.、KERDESKY, FRANCIS A.、+

  DOI：——

  日期：——