1,2,2-Trimethylindan-1-ol | 54963-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1,2,2-Trimethylindan-1-ol
• 英文别名: Trimethylhydroxyindane；1,2,2-trimethyl-3H-inden-1-ol
• CAS: 54963-90-5
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: QDEHCNSAMHLANG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,2,2-Trimethylindan-1-ol 在 sodium azide 、 三氟乙酸 、 氨 作用下， 以 氯仿 、 水 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  AMINOINDAN DERIVATIVE OR SALT THEREOF

  摘要：

  公开号：

  EP2042480B1
• 作为产物：
  描述：

  2,3-二氢-2,2-二甲基茚-1-酮 、 甲基锂 以 乙醚 为溶剂， 反应 14.0h， 以72%的产率得到1,2,2-Trimethylindan-1-ol
  参考文献：
  名称：

  Intramolecular Reactivity of Arylcarbenes: Derivatives of o-Tolylcarbene

  摘要：

  Various CH(2)X groups have been attached to the ortho position of phenylcarbene. If 2'- or 3'-C-H bonds are present, as in 23 (X = Me), 71 (X = CMe(3)), and 58 (X = SiMe(3)), C-H insertion leading to five- or six-membered rings predominates in the gas phase and competes with intermolecular reactions in solution. The formation of benzocyclobutenes via insertion into 1'-C-H bonds is a very minor reaction path of 23 and 71. In contrast, 58 produces substantial amounts of the benzocyclobutene 59 by way of C-Si insertion, particularly in the gas phase. Insertion into the Si-Me bonds of 58 also occurs while the C-F bonds of 37 (X = CF3) and 50 (X = Fl are inert. In the gas phase, 37 and 50 give mainly benzocyclobutenes whereas intermolecular reactions prevail in solution. The effects of sensitization and of solvent polarity suggest that benzocyclobutenes arise from singlet arylcarbenes. The amount of carbene-carbene rearrangement decreases in the order 7 (X = H) > 37 (X = CF3) > 23 (X = Me); no rearrangement was observed with 50 (X = Fl, 58 (X = SiMe(3)), and 71 (X = CMe(3)).

  DOI：

  10.1021/jo00093a014

文献信息

• Process for the Polymerization of Alpha Olefins
  申请人：Resconi Luigi

  公开号：US20080269439A1

  公开（公告）日：2008-10-30

  A process for preparing 1-butene polymers, comprising polymerizing 1-butene or copolymerizing 1-butene with ethylene, propylene or an alpha-olefin of formula CHT 2 =CHT wherein T is a C 3 -C 10 alkyl group, in the presence of a catalyst system obtainable by contacting: A) a metallocene compound belonging to formula (I): wherein M is zirconium titanium or hafnium; X, equal to or different from each other, is a hydrogen atom, a halogen atom, a hydrocarbon radical optionally containing heteroatoms; R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 are hydrogen atoms, or C 1 -C 4O hydrocarbon radicals optionally containing heteroatoms; R 1 , R 2 and R 3 , are linear or branched, C 1 -C 2o -alkyl radicals, optionally containing heteroatoms: B) a Jumoxane or a compound capable of forming an alkyl metallocene cation; and optionally C) organo aluminum compound.

  一种制备1-丁烯聚合物的方法，包括在催化剂系统的存在下聚合1-丁烯或共聚1-丁烯和乙烯、丙烯或化学式为CHT2=CHT的α-烯烃，其中T是C3-C10烷基，所述催化剂系统由以下步骤得到：A）与式（I）属于的金属茂化合物接触，其中M是锆、钛或铪；X，相同或不同，是氢原子、卤素原子、可选含有杂原子的碳氢基；R4、R5、R6、R7、R8、R9、R10、R11、R12和R13是氢原子或C1-C4可选含有杂原子的碳氢基；R1、R2和R3是线性或支链的C1-C2烷基基团，可选含有杂原子。B）Jumoxane或能够形成烷基茂阳离子的化合物；可选C）有机铝化合物。
• AMINOINDANE DERIVATIVE OR SALT THEREOF
  申请人：Hayashibe Satoshi

  公开号：US20090186916A1

  公开（公告）日：2009-07-23

  Provided is a compound that is an NMDA receptor antagonist having a broader safety margin, and is useful as an agent for treating or preventing Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, or pain. A novel compound or a salt thereof, which is characterized in that it has an amino group and R 1 (lower alkyl, cycloalkyl, -lower alkylene-aryl, aryl which may be substituted, and the like) on carbon atoms of indane, cyclopenta[b]thiophene, cyclopenta[b]furan, cyclopenta[b]pyridine, or cyclopenta[c]pyridine ring, or 2,3-dihydrdo-1-benzofuran, 2,3-dihydrdo-1-benzothiophene, indoline ring, or the like, and has R 2 and R 3 (the same or different, each lower alkyl or aryl) on carbon atoms beside them, and an NMDA receptor antagonist comprising the same as an active component.

  提供的化合物是一种NMDA受体拮抗剂，具有更广泛的安全边际，可用作治疗或预防阿尔茨海默病、脑血管性痴呆、帕金森病、缺血性卒中或疼痛的药剂。 一种新型化合物或其盐，其特征在于在茚烷、环戊[b]噻吩、环戊[b]呋喃、环戊[b]吡啶或环戊[c]吡啶环的碳原子上具有氨基和R1（较低的烷基、环烷基、-较低的烷基-芳基、可能被取代的芳基等），或2,3-二氢-1-苯并呋喃、2,3-二氢-1-苯并噻吩、吲哚环或类似物，并且在它们旁边的碳原子上具有R2和R3（相同或不同，每个都是较低的烷基或芳基），以及包含其作为活性成分的NMDA受体拮抗剂。
• PROCESS FOR THE POLYMERIZATION OF ALPHA OLEFINS
  申请人：Basell Polyolefine GmbH

  公开号：EP1877453A1

  公开（公告）日：2008-01-16
• US7964679B2
  申请人：——

  公开号：US7964679B2

  公开（公告）日：2011-06-21
• US8013018B2
  申请人：——

  公开号：US8013018B2

  公开（公告）日：2011-09-06