2-[13-[[4-[(2-溴乙酰基)氨基]苯基]甲基]-4,8,11-三(羧甲基)-1,4,8,11-四氮杂环十四碳-1-基]乙酸 | 121697-38-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-[13-[[4-[(2-溴乙酰基)氨基]苯基]甲基]-4,8,11-三(羧甲基)-1,4,8,11-四氮杂环十四碳-1-基]乙酸
• 英文名称: 6-(4-Bromoacetamidobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid
• 英文别名: 2-[6-[[4-[(2-bromoacetyl)amino]phenyl]methyl]-4,8,11-tris(carboxymethyl)-1,4,8,11-tetrazacyclotetradec-1-yl]acetic acid
• CAS: 121697-38-9
• 化学式: C₂₇H₄₀BrN₅O₉
• 分子量: 658.5
• InChiKey: GNTDHMNLBPOHHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.1
• 重原子数：
  42
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  191
• 氢给体数：
  5
• 氢受体数：
  13

文献信息

• Pulmonary delivery for bioconjugation
  申请人：CONJUCHEM, INC.

  公开号：US20040156859A1

  公开（公告）日：2004-08-12

  Methods of and compositions for pulmonary delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest or which have formed a covalent bond with a pulmonary solution protein are disclosed. Therapeutic agents useful in the invention include wound healing agents, antibiotics, anti-inflammatories, anti-oxidants, anti-proliferatives, immunosupressants, anti-infective and anti-cancer agents.

  本发明公开了一种可与感兴趣的部位形成共价键或已与肺溶液蛋白形成共价键的治疗剂的肺部输送方法和组成物。本发明中有用的治疗剂包括伤口愈合剂、抗生素、抗炎剂、抗氧化剂、抗增殖剂、免疫抑制剂、抗感染和抗癌剂。
• Local delivery of long lasting therapeutic agents
  申请人：——

  公开号：US20030170250A1

  公开（公告）日：2003-09-11

  Methods of and compositions for localized delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest are disclosed. Therapeutic agents useful in the invention include wound healing agents, antibiotics, anti-inflammatories, anti-oxidants, anti-proliferatives, immunosupressants, anti-infective and anti-cancer agents.

  本发明公开了能够与相关部位形成共价键的治疗剂的局部给药方法和组合物。对本发明有用的治疗剂包括伤口愈合剂、抗生素、抗炎剂、抗氧化剂、抗增殖剂、免疫抑制剂、抗感染剂和抗癌剂。
• DELIVERY OF LONG LASTING THERAPEUTIC AGENTS BY FORMING COVALENT ATTACHMENTS IN VIVO
  申请人：Conjuchem, Inc.

  公开号：EP1042003A1

  公开（公告）日：2000-10-11
• BIOCONJUGATION IN VIVO TO PULMONARY OR BLOOD COMPONENTS
  申请人：Conjuchem, Inc.

  公开号：EP1235618A2

  公开（公告）日：2002-09-04
• VERSION OF FDG DETECTABLE BY SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY
  申请人：MALLINCKRODT LLC

  公开号：US20140378677A1

  公开（公告）日：2014-12-25

  A compound comprising a metal chelate linked to a hexose carrier for use as a metallopharmaceutical diagnostic or therapeutic agent is provided. The compound is suitable for imaging by single-photon emission computed tomography, computer assisted tomography, magnetic resonance spectroscopy, magnetic resonance imaging, positron emission tomography, fluorescence imaging or x-ray.