Benzylaethylphosphinsaeure | 13345-29-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzylaethylphosphinsaeure
• 英文别名: Benzyl(ethyl)phosphinic acid
• CAS: 13345-29-4
• 化学式: C₉H₁₃O₂P
• 分子量: 184.175
• InChiKey: MRGOJMASOICDHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Benzylaethylphosphinsaeure 在 硝酸 作用下， 生成 p-Nitrobenzylaethylphosphinsaeure
  参考文献：
  名称：

  Bratkowski,T. et al., Roczniki Chemii, 1967, vol. 41, p. 471 - 477

  摘要：

  DOI：
• 作为产物：
  描述：

  Benzylaethylphosphinsaeureisopropylester 在 盐酸 作用下， 生成 Benzylaethylphosphinsaeure
  参考文献：
  名称：

  Bratkowski,T. et al., Roczniki Chemii, 1967, vol. 41, p. 471 - 477

  摘要：

  DOI：

文献信息

• ——
  作者：N. I. Ivanova、N. K. Gusarova、A. M. Reutskaya、S. I. Shaikhutdinova、S. N. Arbuzova、B. A. Trofimov

  DOI：10.1023/a:1026340532022

  日期：——

  Symmetrical and unsymmetrical tertiary phosphine oxides containing benzyl and 5-chloro-2-thienyl radicals stereoselectively react with benzaldehyde in the sodium amide-THF system to form the E isomers of 1-organyl-2-phenylethene and diorganylphosphinic acids in high yields. Triethyl, tris(2-phenyl-4 ethyl)-, and tris[(4-methoxyphenyl)methyl]phosphine oxides under the above-mentioned conditions do not react with benzaldehyde.
• Compounds which bind PSMA and uses thereof
  申请人：Heston Warren D.W.

  公开号：US20080311037A1

  公开（公告）日：2008-12-18

  A compound is represented by Structural Formula A1: C—B-L-A  A1 or a pharmaceutically acceptable salt or solvate thereof. A is a prostate specific membrane antigen (PSMA) ligand; L is an optionally substituted aliphatic or heteroaliphatic linking group; B includes at least one optionally substituted moiety selected from the group consisting of a sugar, a charged group, an aryl ring, and a heteroaryl ring, wherein B optionally includes a drug or a labeling agent; and C is H, a drug, or a labeling agent, wherein CB together comprises the drug or the labeling agent. The compounds are useful as PSMA agents and in pharmaceutical compositions, methods for treating and detecting diseases such as cancer in a subject, methods for identifying cancer cells in a sample, methods for inhibiting tumor neovascularization, methods for identifying drugs that can treat cancer, and the like.
• [EN] IRON(III) MACROCYCLIC COMPLEXES WITH MIXED HYROXYL PENDANTS AS MRI CONTRAST AGENTS<br/>[FR] COMPLEXES MACROCYCLIQUES DE FER(III) PRÉSENTANT DES GROUPES PENDANTS HYDROXYLE EN TANT QU'AGENTS DE CONTRASTE POUR IRM
  申请人：[en]THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：WO2022204065A1

  公开（公告）日：2022-09-29

  The present application describes novel Fe(III) macrocyclic complexes that have hydroxy pendants with a third anionic ancillary group for improved MR imaging in vivo. The complexes have the following general structure:(I) or (II) where high spin Fe(III) is chelated thereto. The present application also describes novel Fe(III) macrocyclic complexes that have hydroxypropyl pendants with a third anionic ancillary group for improved MR imaging in vivo. The complexes have the following general structure.
• Bratkowski,T. et al., Roczniki Chemii, 1967, vol. 41, p. 471 - 477
  作者：Bratkowski,T. et al.

  DOI：——

  日期：——