3-s-butylthiophene | 79428-76-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 3-s-butylthiophene
• 英文别名: 3-(sec-butyl)thiophene；Thiophene, 3-(1-methylpropyl)；3-butan-2-ylthiophene
• CAS: 79428-76-5
• 化学式: C₈H₁₂S
• 分子量: 140.249
• InChiKey: BJFMQAVZFWVZJS-UHFFFAOYSA-N

物化性质

• 沸点：
  180.2±9.0 °C(Predicted)
• 密度：
  0.963±0.06 g/cm3(Predicted)
• 保留指数：
  1011

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-碘噻吩 、 2-碘丁烷 在 锌 、 α,α,α-三联吡啶 、 nickel dichloride 作用下， 以 四氢呋喃 为溶剂， 反应 26.0h， 以61%的产率得到3-s-butylthiophene
  参考文献：
  名称：

  Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides and Aryl Iodides

  摘要：

  A general Ni-catalyzed process for the cross-coupling of secondary alkylzinc halides and aryl/heteroaryl iodides has been developed. This is the first process to overcome the isomerization and beta-hydride elimination problems that are associated with the use of secondary nucleophiles, and that have limited the analogous Pd-catalyzed systems. The impact of salt additives was also investigated. It was found that the presence of LiBF4 dramatically improves both isomeric retention and yield for challenging substrates.

  DOI：

  10.1021/ol200098d

文献信息

• Regiospecific Synthesis of 3-Alkylfurans and 3-Alkylthiophenes<i>via</i>Organoboranes
  作者：Itaru Akimoto、Masahiro Sano、Akira Suzuki

  DOI：10.1246/bcsj.54.1587

  日期：1981.5

  The reaction of bromine or iodine with ate-complexes obtained from trialkylboranes and 3-lithiofuran or 3-lithiothiophene gives the corresponding 3-alkylfurans or 3-alkylthiophenes in good yields, respectively.

  溴或碘与从三烷基硼烷和 3- 硫代呋喃或 3- 锂噻吩获得的 ate 络合物的反应分别以良好的产率得到相应的 3- 烷基呋喃或 3- 烷基噻吩。
• MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
  申请人：ZHU Yan

  公开号：US20100087468A1

  公开（公告）日：2010-04-08

  The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.

  本发明涉及一些新型化合物，其由公式（I）表示，以及其药学上可接受的盐、溶剂、水合物和前药。本发明还涉及制备和使用这些化合物的方法，以及含有这些化合物的药物组合物，用于治疗或控制由PPAR介导的许多疾病，例如葡萄糖代谢、脂质代谢和胰岛素分泌，具体包括2型糖尿病、高胰岛素血症、高脂血症、高尿酸血症、高胆固醇血症、动脉粥样硬化、一种或多种心血管疾病的风险因素、X综合症、高三酰甘油血症、高血糖、肥胖和进食障碍。
• Solution processible forms of neutral and electrically conductive poly(substituted heterocycles)
  申请人：ALLIED CORPORATION

  公开号：EP0203438A1

  公开（公告）日：1986-12-03

  This invention relates to solutions comprising doped and undoped poly(substituted heterocycles) and an organic solvent which can be used to form conducting polymer articles, including films.

  本发明涉及由掺杂和未掺杂的聚（取代杂环）和有机溶剂组成的溶液，可用于形成导电聚合物制品，包括薄膜。
• Electrically conductive material and a process for the preparation of same and secondary battery using the electrically conductive material
  申请人：SANYO ELECTRIC CO., LTD.

  公开号：EP0261837A2

  公开（公告）日：1988-03-30

  New electrically conductive material suitable particularly for a secondary battery and a process for preparing the electrically conductive material are provided. The process for the preparation of the electrically conductive material comprises the steps of reacting a compound having conjugated double bonds with an oxidizing agent wherein the oxidizing agent comprises a cupric compound and a nitrile compound. The electrically conductive material comprises grainy polypyrrole obtained by reacting a pyrrole compound with an oxidizing agent which is constituted by primary particles having an average particle size of 0.01 to 0.4 µm and has a press molding density of 1 to 1.6 g/cm³.

  本发明提供了特别适用于二次电池的新型导电材料以及制备该导电材料的工艺。 制备该导电材料的工艺包括以下步骤：使具有共轭双键的化合物与氧化剂反应，其中氧化剂包括铜化合物和腈化合物。 该导电材料包括通过使吡咯化合物与氧化剂反应而获得的粒状聚吡咯，该聚吡咯由平均粒径为 0.01 至 0.4 微米的初级颗粒构成，其压制成型密度为 1 至 1.6 克/立方厘米。
• Polymer compositions
  申请人：NIPPON OIL CO., LTD.

  公开号：EP0350166A2

  公开（公告）日：1990-01-10

  A polymer composition which is superior in process­ability, exhibits an extremely superior electroconductive characteristic when doped using an electron acceptor, and which comprises. (A) a copolymer represented by the following general formula (I): wherein R¹ is a hydrogen atom or a hydrocarbon residue having 1 to 20 carbon atoms, R² is a hydrogen atom, a hydrocarbon residue having 1 to 20 carbon atoms, furyl, pyridyl, nitrophenyl, chlorophenyl, or methoxyphenyl, n and x are each an integer not smaller than 2; and (B) one or more compounds selected from the group consisting of: polypyrrole compounds represented by the following general formula (II): wherein R³, R⁴ and R⁵ are each a hydrogen atom or a hydrocarbon residue having 1 to 20 carbon atoms, and p is an integer not smaller than 2; polythiophene compounds represented by the following general formula (III): wherein R⁶ and R⁷ are each a hydrogen atom or a hydro­carbon residue having 1 to 10 carbon atoms, and q is an integer not smaller than 2, and polyaniline compounds represented by the following general formula (IV): wherein R⁸, R⁹, R¹⁰ and R¹¹ are each a hydrogen atom or a hydrocarbon residue having 1 to 10 carbon atoms, and r is an integer not smaller than 2.

  一种聚合物组合物，其加工性能优越，在掺入电子受体时具有极佳的导电特性，它包括 (A) 由以下通式(I)表示的共聚物： 其中 R¹ 为氢原子或具有 1 至 20 个碳原子的烃残基，R² 为氢原子、具有 1 至 20 个碳原子的烃残基、呋喃基、吡啶基、硝基苯基、氯苯基或甲氧基苯基，n 和 x 均为不小于 2 的整数；以及 (B) 选自以下组别的一种或多种化合物： 由下式通式(II)表示的聚吡咯化合物： 其中 R³、R⁴ 和 R⁵ 各为氢原子或具有 1 至 20 个碳原子的烃残基，且 p 为不小于 2 的整数； 由下式通式(III)表示的聚噻吩化合物： 其中 R⁶ 和 R⁷ 各为氢原子或具有 1 至 10 个碳原子的烃残基，且 q 为不小于 2 的整数；以及由以下通式（IV）表示的聚苯胺化合物： 其中 R⁸、R⁹、R¹⁰ 和 R¹¹ 各为氢原子或具有 1 至 10 个碳原子的烃残基，且 r 为不小于 2 的整数。