2,6-diphenyl-4-acetylaniline | 203051-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-diphenyl-4-acetylaniline
• 英文别名: 4-acetyl-2,6-diphenylaniline；1-(4-Amino-3,5-diphenylphenyl)ethanone
• CAS: 203051-55-2
• 化学式: C₂₀H₁₇NO
• 分子量: 287.361
• InChiKey: HTVKHRVZKDMNJY-UHFFFAOYSA-N

物化性质

• 熔点：
  138-139 °C
• 沸点：
  497.2±45.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-diphenyl-4-acetylaniline 在 potassium carbonate 、 lead dioxide 、 三乙胺 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 N-[(4-nitrophenyl)thio]-4-acetyl-2,6-diphenylphenylaminyl
  参考文献：
  名称：

  Stable Thioaminyl Radicals Having Functional Groups:  Generation, ESR Spectra, Isolation, X-ray Crystallographic Analyses, and Magnetic Characterization of N-(Arylthio)-4-(ethoxycarbonyl)-2,6-diarylphenylaminyls, N-(Arylthio)-4-acetyl-2,6-diarylphenylaminyls, and N-(Arylthio)-4-cyano-2,6-diarylphenylaminyls¹

  摘要：

  Oxidation of N-(arylthio)-4-(ethoxycarbonyl)-2,6-diarylanilines (9), N-(arylthio)-4-acetyl-2,6-diarylanilines (10), and N-(arylthio)-4-cyano-2,6-diarylanilines (11) with PbO2 yielded quite persistent N-(arylthio)-4-(ethoxycarbonyl)-2,6-diarylphenylaminyls (4), N-(arylthio)-4-acetyl-2,6-diarylphenylaminyls (5), and N-(arylthio)-4-cyano-2,6-diarylphenylaminyls (6), respectively, and they were isolated as pure radical crystals. On the other hand, N-(arylthio)-4-nitro-2,6-diarylphenylaminyls (6), and N-(arylthio)-4-chloro-2,6-diarylphenylaminyls (7), were unstable and soon decomposed. The X-ray crystallographic analyses of N-[(2,4-dichlorophenyl)thio]-4-acetyl-2, diphenylphenylaminyl (5c) and N-[(2,4-dichlorophenyl)thio]-4-cyano-2,6-diphenylphenylaminyl (6c) showed that the Ph-N-S-Ph pi-framework is planar, and the 2- and 6-phenyl groups are twisted from the coplane. The ESR studies for 4-8 showed that their hyperfine coupling constants are nearly identical to each other and that the unpaired electron is extensively delocalized onto the anilino benzene ring and the arylthiyl group. The magnetic susceptibility measurements were carried out for five thioaminyl radical crystals and showed that one radical couples ferromagnetically with 2J/k(B) = 16.0 K, and the other four radicals couple antiferromagnetically with 2J/k(B) = -15.6 to -194.6 K or theta = -0.6 to -5.0 K.

  DOI：

  10.1021/jo9718206
• 作为产物：
  描述：

  4-氨基-3,5-二溴苯乙酮 、 苯硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 乙醇 、 水 、 苯 为溶剂， 反应 14.0h， 以72%的产率得到2,6-diphenyl-4-acetylaniline
  参考文献：
  名称：

  Stable Thioaminyl Radicals Having Functional Groups:  Generation, ESR Spectra, Isolation, X-ray Crystallographic Analyses, and Magnetic Characterization of N-(Arylthio)-4-(ethoxycarbonyl)-2,6-diarylphenylaminyls, N-(Arylthio)-4-acetyl-2,6-diarylphenylaminyls, and N-(Arylthio)-4-cyano-2,6-diarylphenylaminyls¹

  摘要：

  Oxidation of N-(arylthio)-4-(ethoxycarbonyl)-2,6-diarylanilines (9), N-(arylthio)-4-acetyl-2,6-diarylanilines (10), and N-(arylthio)-4-cyano-2,6-diarylanilines (11) with PbO2 yielded quite persistent N-(arylthio)-4-(ethoxycarbonyl)-2,6-diarylphenylaminyls (4), N-(arylthio)-4-acetyl-2,6-diarylphenylaminyls (5), and N-(arylthio)-4-cyano-2,6-diarylphenylaminyls (6), respectively, and they were isolated as pure radical crystals. On the other hand, N-(arylthio)-4-nitro-2,6-diarylphenylaminyls (6), and N-(arylthio)-4-chloro-2,6-diarylphenylaminyls (7), were unstable and soon decomposed. The X-ray crystallographic analyses of N-[(2,4-dichlorophenyl)thio]-4-acetyl-2, diphenylphenylaminyl (5c) and N-[(2,4-dichlorophenyl)thio]-4-cyano-2,6-diphenylphenylaminyl (6c) showed that the Ph-N-S-Ph pi-framework is planar, and the 2- and 6-phenyl groups are twisted from the coplane. The ESR studies for 4-8 showed that their hyperfine coupling constants are nearly identical to each other and that the unpaired electron is extensively delocalized onto the anilino benzene ring and the arylthiyl group. The magnetic susceptibility measurements were carried out for five thioaminyl radical crystals and showed that one radical couples ferromagnetically with 2J/k(B) = 16.0 K, and the other four radicals couple antiferromagnetically with 2J/k(B) = -15.6 to -194.6 K or theta = -0.6 to -5.0 K.

  DOI：

  10.1021/jo9718206

文献信息

• Magnetic Interaction of Pyridyl-Substituted Thioaminyl Stable Free Radicals¹
  作者：Yozo Miura、Yuichi Oyama、Yoshio Teki

  DOI：10.1021/jo0205659

  日期：2003.2.1

  as radical crystals. Their ESR spectra were measured, and the NS and pyridyl nitrogen and anilino meta and pyridyl ortho and para proton hyperfine coupling constants were determined. The spin-density calculations based on the density functional theory were performed by the UBecke 3LYP hybrid method using the STO 6-31G basis set. X-ray crystallographic analyses were performed for three radicals, and

  N-（2-吡啶硫基）-2,6-二芳基-4-R-苯胺基（R = Ph，4-ClC（6）H（4），MeCO，CN，EtOCO）和N-（4-吡啶硫基）-制备2,6-二芳基-4-R-苯胺基（R = Ph，4-ClC（6）H（4），EtOCO）并分离为自由基晶体。测量了它们的ESR谱，并测定了NS和吡啶基氮以及苯胺基间和吡啶基邻和对质子的超精细耦合常数。基于密度泛函理论的自旋密度计算是通过UBecke 3LYP混合方法，使用STO 6-31G基集进行的。对三个自由基进行了X射线晶体学分析，并详细讨论了它们的结构。用SQUID磁力计对9种离析的自由基进行磁化率测量。一个基团显示出铁磁耦合（2J / k（B）= 44 K），其他显示反铁磁行为。根据晶体结构解释了观察到的磁相互作用。
• Heterocycle-Substituted Stable Thioaminyl Radicals:  Isolation, ESR Spectra, and Magnetic Properties¹
  作者：Yozo Miura、Tatsuya Tomimura、Yoshio Teki

  DOI：10.1021/jo000901q

  日期：2000.11.1

  N-[(2-Benzothiazolyl)thio]- (1), N-[(2-benzoxazolyl)thio]- (2), and N-(2-pyrimidylthio)-2,4,6-trisubstituted-phenylaminyls (3) were generated by oxidation of the corresponding amines. Although 2 and 3 were not sufficiently persistent to be isolated, 1 was very persistent and could be isolated as radical crystals. The ESR spectra of nondeuterated and partially deuterated 1-3 radicals were measured,

  N-[（2-苄基噻唑基）硫基]-（1），N-[（2-苯并恶唑基）硫基]-（2）和N-（2-嘧啶基硫基）-2,4,6-三取代-苯基氨基（3 ）是由相应的胺氧化生成的。尽管2和3不够持久，无法分离，但1却非常持久，可以分离为自由基晶体。测量了未氘代和部分氘代的1-3个自由基的ESR光谱，并根据超精细偶合常数估算了自旋密度分布。进行了从头算的分子轨道计算，以更详细地讨论自旋密度分布。对一个自由基进行了单晶X射线晶体学分析。用SQUID测量了分离出的四个自由基的磁性能。两个自由基显示出铁磁相互作用，并用一维规则Heisenberg模型分析chiT与T曲线，得出2J / k（B）= 5.8和8.6K。其余两个自由基显示出反铁磁相互作用。使用居里-魏斯定律或二聚体模型对chiT vs T图进行分析得出theta = -1.4 K和2J / k（B）= -1370K。强反铁磁相互作用可以用X射线晶体学结果来解释。