4-chloro-3,5-dinitro-N-methylbenzamide | 349417-75-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-3,5-dinitro-N-methylbenzamide
• 英文别名: 4-chloro-N-methyl-3,5-dinitrobenzamide
• CAS: 349417-75-0
• 化学式: C₈H₆ClN₃O₅
• 分子量: 259.606
• InChiKey: RPEMZNRSYSNHFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-chloro-3,5-dinitro-N-methylbenzamide 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 16.0h， 生成 N-methyl-7-nitro-2-(piperidine-1-carbonyl)benzo[d]thiazole-5-carboxamide
  参考文献：
  名称：

  Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase

  摘要：

  We report the discovery of benzothiazoles, a novel anti-mycobacterial series, identified from a whole cell based screening campaign. Benzothiazoles exert their bactericidal activity against Mycobacterium tuberculosis (Mtb) through potent inhibition of decaprenylphosphoryl-beta-D-ribose 2'-oxidase (DprE1), the key enzyme involved in arabinogalactan synthesis. Specific target linkage and mode of binding were established using co-crystallization and protein mass spectrometry studies. Most importantly, the current study provides insights on the utilization of systematic medicinal chemistry approaches to mitigate safety liabilities while improving potency during progression from an initial genotoxic hit, the benzothiazole N-oxides (BTOs) to the lead-like AMES negative, crowded benzothiazoles (cBTs). These findings offer opportunities for development of safe clinical candidates against tuberculosis. The design strategy adopted could find potential application in discovery of safe drugs in other therapy areas too. (c) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.11.017
• 作为产物：
  描述：

  4-氯-3,5-二硝基苯甲酸 在 五氯化磷 作用下， 以 水 、 丙酮 为溶剂， 反应 2.5h， 生成 4-chloro-3,5-dinitro-N-methylbenzamide
  参考文献：
  名称：

  Benbow, John W.; Bernberg, Erin L.; Korda, Anna, Antimicrobial Agents and Chemotherapy, 1998, vol. 42, # 2, p. 339 - 343

  摘要：

  DOI：