2-Methyl-pentan-carbonsaeure-(1)-chlorid | 57323-93-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 2-Methyl-pentan-carbonsaeure-(1)-chlorid
• 英文别名: 3-methyl-hexanoyl chloride；3-Methylhexanoyl chloride
• CAS: 57323-93-0
• 化学式: C₇H₁₃ClO
• 分子量: 148.633
• InChiKey: WQUHOPYYHSPFQC-UHFFFAOYSA-N

物化性质

• 沸点：
  203.58°C (rough estimate)
• 密度：
  0.9670

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Methyl-pentan-carbonsaeure-(1)-chlorid 在 氨 作用下， 生成 2-Methyl-pentan-carbonsaeure-(1)-amid
  参考文献：
  名称：

  Graf,R., Justus Liebigs Annalen der Chemie, 1963, vol. 661, p. 111 - 157

  摘要：

  DOI：
• 作为产物：
  描述：

  异己烯 在 氯化亚砜 作用下， 生成 2-Methyl-pentan-carbonsaeure-(1)-chlorid
  参考文献：
  名称：

  Graf,R., Justus Liebigs Annalen der Chemie, 1963, vol. 661, p. 111 - 157

  摘要：

  DOI：

文献信息

• Studies on hypolipidemic agents. II Synthesis of 1-arenesulfonyloxy-2-alkanone derivatives as potent esterase inhibitors and hypolipidemic agents.
  作者：KAZUO OGAWA、TADAFUMI TERADA、YOSHIYUKI MURANAKA、TOSHIHIRO HAMAKAWA、SADAO HASHIMOTO、SETSURO FUJII

  DOI：10.1248/cpb.34.3252

  日期：——

  Many 2-oxoalkyl arenesulfonate derivatives having straight or branched alkyl chains of different lengths, 2-oxoalkyl bis-arenesulfonate derivatives, and alkyl arenesulfonate derivatives having a ketal moiety at the 2-position on the alkyl chain were synthesized, and their esterase-inhibitory activities, as well as hypolipidemic activities, were evaluated.Among these compounds, 1-(2, 4, 6-trimethylbenzenesulfonyloxy)-2-dodecanone (III-1u), and 1-(2, 3, 4, 6-tetramethylbenzenesulfonyloxy)-2-hexanone (III-1w), -2-octanone (III-1x) and -2-decanone (III-1y) exhibited potent esterase-inhibitory activities (IC50=3×10-10, 2×10-10, 2×10<-10> and 3×<-11>M, respectively). However, the sulfonate (XV) having a ketal moiety on the alkyl chain and the bis-sulfonate (XVI) exhibited low inhibitory activities toward esterase in comparison with III and XII. Most of the compounds III and some of the compounds XII exhibited potent hypolipidemic activities corresponding to more than 50% lipid-lowering effect (plasma triglyceride and cholesterol ester) in vivo. The structure-activity relatioinships of these compounds are discussed.

  合成了许多具有直链或支链不同长度烷基链的2-氧代烷基芳磺酸盐衍生物、2-氧代烷基双芳磺酸盐衍生物以及在烷基链的2-位具有缩酮部分的烷基芳磺酸盐衍生物，并评估了它们的酯酶抑制活性及降血脂活性。在这些化合物中，1-(2,4,6-三甲基苯磺酰氧基)-2-十二烷酮（III-1u）、1-(2,3,4,6-四甲基苯磺酰氧基)-2-己烷酮（III-1w）、-2-辛烷酮（III-1x）和-2-癸烷酮（III-1y）表现出强效的酯酶抑制活性（IC50分别为3×10-10、2×10-10、2×10-10和3×10-11M）。然而，相对于III和XII，具有烷基链上缩酮部分的磺酸盐（XV）和双磺酸盐（XVI）对酯酶的抑制活性较低。大多数化合物III和部分化合物XII表现出强效的降血脂活性，对应于体内超过50%的脂质降低效果（血浆甘油三酯和胆固醇酯）。讨论了这些化合物的构效关系。
• Cannabinoid receptor ligands and uses thereof
  申请人：Pfizer Inc.

  公开号：US20040077650A1

  公开（公告）日：2004-04-22

  Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the modulation of the cannabinoid receptors in animals are described herein. 1

  本文描述了作为大麻素受体配体的化合物（I）及其在治疗与动物体内大麻素受体调节相关疾病中的用途。
• CELLULOSE DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF, CELLULOSE RESIN COMPOSITION, MOLDED ARTICLE AND METHOD FOR PRODUCTION THEREOF, AND HOUSING FOR ELECTROCHEMICAL DEVICE
  申请人：FUJIFILM Corporation

  公开号：EP2295470A1

  公开（公告）日：2011-03-16

  A cellulose derivative having good thermal plasticity, strength, heat resistance and mold working suitability is provided. The cellulose derivative is a cellulose derivative obtained from cellulose by substitution of hydrocarbyl groups ranging in carbon number from 1 to 7 and aliphatic acyl groups ranging in carbon number from 4 to 11 for at least part of the hydrogen atoms of hydroxyl groups contained in the cellulose.

  提供了一种具有良好热可塑性、强度、耐热性和模具加工适应性的纤维素衍生物。 这种纤维素衍生物是从纤维素中通过用碳原子数为 1 至 7 的烃基和碳原子数为 4 至 11 的脂肪酰基取代纤维素中所含羟基的至少部分氢原子而得到的纤维素衍生物。
• CELLULOSE DERIVATIVE, RESIN COMPOSITION, MOLDED ARTICLE AND PROCESS FOR PRODUCTION THEREOF, AND HOUSING FOR ELECTRIC AND ELECTRONIC DEVICE
  申请人：FUJIFILM Corporation

  公开号：EP2465874A1

  公开（公告）日：2012-06-20

  A cellulose derivative, contains A) a hydrocarbon group; B) a group containing an acyl group: -CO-RB and an ethyleneoxy group: -C2H4-O- (RB represents a hydrocarbon group); and C) an acyl group: -CO-RC (RC represents a hydrocarbon group).

  纤维素衍生物，包含 A) 一个烃基；B) 一个含有酰基：-CO-RB 和乙烯氧基：-C2H4-O-（RB 代表一个烃基）的基团；以及 C) 一个酰基：-CO-RC（RC 代表一个烃基）。
• CELLULOSE DERIVATIVE, THERMOFORMED MATERIAL, MOLDED BODY, PRODUCTION METHOD THEREFOR, AND CASING FOR ELECTRICAL AND ELECTRONIC EQUIPMENT
  申请人：FUJIFILM Corporation

  公开号：EP2465899A1

  公开（公告）日：2012-06-20

  A thermo-molding material contains a water-insoluble cellulose derivative, wherein the water-insoluble cellulose derivative comprises: A) a hydrocarbon group; B) a group containing an acyl group: -CO-RB1 and an alkyleneoxy group: -RB2-O- (RB1 represents a hydrocarbon group, and RB2 represents an alkylene group having 3 carbon atoms); and C) an acyl group: -CO-RC (RC represents a hydrocarbon group).

  一种热成型材料含有一种水不溶性纤维素衍生物，其中水不溶性纤维素衍生物包括：A）烃基；B）含有酰基：-CO-RB1 和亚烷氧基：-RB2-O-（RB1 代表烃基，RB2 代表具有 3 个碳原子的亚烷基）的基团；以及 C）酰基：-CO-RC（RC 代表烃基）。