L-dopa

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-dopa
• 英文别名: (2S)-2-azaniumyl-3-(3,5-dihydroxyphenyl)propanoate
• 化学式: C₉H₁₁NO₄
• 分子量: 197.191
• InChiKey: AIPXVSTVIOUDIU-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  L-dopa 在 氧气 、 酪氨酸酶 作用下， 以 phosphate buffer 为溶剂， 生成 dopachrome
  参考文献：
  名称：

  Kinetic Study of the Oxidation of Quercetin by Mushroom Tyrosinase

  摘要：

  The kinetic behavior of mushroom tyrosinase in the presence of the flavonol quercetin was studied. This flavonol was oxidized by mushroom tyrosinase and the reaction was followed by recording spectral changes over time. The spectra obtained during the reaction showed two isosbectic points, indicating a stable o-quinone. When quercetin was oxidized by tyrosinase in the presence of cysteine and 3-methyl-2-benzothiazolone hydrazone (Besthorn's hydrazone, MBTH) isosbestic points were also observed indicating a definite stoichiometry. From the data analysis of the initial rate) in the presence of MBTH, the kinetic parameters: V-max(app) = (16.2 +/- 0.6) muM/min, K-m(app) = (0.12 +/- 0.01) mM, (V-max(app)/K-m(app)) = (V-max/K-S') = (13.5 +/- 1.4) x 10(-2) min(-1), k(cat)(app) (6.2 +/- 0.6) s(-1) were determined. We propose that quercetin acts simultaneously as a substrate and a rapid reversible inhibitor of mushroom tyrosinase, depending on how it binds to the copper atom of the enzyme active site. Thus, if the binding occurs through the hydroxylic groups at the C3' and C4' positions, quercetin acts as a substrate, while if it occurs through the hydroxylic group at the C3 position of the pyrone ring, quercetin acts as an inhibitor.

  DOI：

  10.1021/jf034656y

文献信息

• NOVEL MULTIMERIC MOLECULES, A PROCESS FOR PREPARING THE SAME AND THE USE THEREOF FOR MANUFACTURING MEDICINAL DRUGS
  申请人：Guichard Gilles

  公开号：US20100136034A1

  公开（公告）日：2010-06-03

  The invention relates to a compound of the formula (I): in which k and j are independently 0 or 1, Y is a macrocycle in which the cycle includes 9 to 36 carbon atoms and is functionalised by three amino functions and by a chain for attaching the spacer arm Z via an X bond, R c is a binding pattern with a receptor of the TNF superfamily, X is a chemical function for binding the Y group to the space arm, and Z is a bi-, tri- or tetra-functional spacer arm.

  该发明涉及以下式（I）的化合物： 其中k和j独立地为0或1，Y是一个大环，其中该环包括9至36个碳原子，并且通过三个氨基功能和通过链将间隔臂Z通过X键连接的功能化，Rc是与TNF超家族受体的结合模式，X是用于将Y基固定到空间臂的化学功能，Z是双功能、三功能或四功能间隔臂。
• NOVEL MULTIMERIC CD40 LIGANDS, METHOD FOR PREPARING SAME AND USE THEREOF FOR PREPARING DRUGS
  申请人：Guichard Gilles

  公开号：US20100183642A1

  公开（公告）日：2010-07-22

  The invention concerns a compound of formula (I), wherein Y represents a macrocycle whereof the cycle comprises 9 to 36 atoms, and is functionalized by three amine or COOH functions; R c represents a group of formula H—X a —X b —X c —X d —X e —(X f ) i —, wherein i represents 0 or 1, X n is in particular selected among lysine, arginine, ornithine residues, X b is in particular selected among glycine, asparagine, L-proline or D-proline residues, X c et X d are in particular selected among tyrosine, phenylalanine or 3-nitrotyrosine residues, X e et X f are in particular selected among the following amino acid residues: NH 2 —(CH 2 ) n —COOH, n ranging from 1 to 10 or NH 2 —(CH 2 —CH 2 —O) m —CH 2 CH 2 COOH, m ranging from 3 to 6, provided that one at least of the amino acid residues X a , X b , X c and X d is different from the corresponding amino acid in the sequence of the natural CD40 143 Lys-Gly-Tyr-Tyr 146 fragment

  该发明涉及一种化合物，其化学式为（I），其中Y代表一个大环，该环包含9至36个原子，并且通过三个胺基或COOH功能官能化；Rc代表一个化学式为H—Xa—Xb—Xc—Xd—Xe—（Xf）i—的基团，其中i代表0或1，Xn特别选自赖氨酸、精氨酸、鸟氨酸残基之一，Xb特别选自甘氨酸、天冬氨酸、L-脯氨酸或D-脯氨酸残基之一，Xc和Xd特别选自酪氨酸、苯丙氨酸或3-硝基酪氨酸残基之一，Xe和Xf特别选自以下氨基酸残基之一：NH2—（CH2）n—COOH，其中n取1至10之间的值，或NH2—（CH2—CH2—O）m—CH2CH2COOH，其中m取3至6之间的值，前提是氨基酸残基Xa、Xb、Xc和Xd中至少有一个与天然CD40143Lys-Gly-Tyr-Tyr146片段中相应的氨基酸不同。
• Mutant tyrosine repressor gene and utilization thereof
  申请人：Kumagai Hidehiko

  公开号：US20050089967A1

  公开（公告）日：2005-04-28

  A gene coding for a mutant tyrosine repressor having increased positive regulatory activity for expression of the tyrosine phenol lyase gene compared with a tyrosine repressor not having mutation is obtained by introducing a mutation into a tyrosine repressor gene of Erwinia herbicola , introducing the gene into which the mutation is introduced into Escherichia coli expressing a lactose operon under the control of a promoter and enhancer of the tyrosine phenol lyase gene derived from Erwinia herbicola , and selecting a transformed strain having increased β-galactosidase activity.

  通过将突变引入Erwinia herbicola的酪氨酸抑制剂基因中，将带有突变的基因引入到表达在酪氨酸酚类解酶基因的启动子和增强子下的乳糖操纵子中的Escherichia coli中，选择具有增强β-半乳糖苷酶活性的转化菌株，获得编码具有增强正调节活性的突变酪氨酸抑制剂的基因。
• INKORPORATION VON PHARMAKOLOGISCH WIRKSAMEN AMINOSÄUREANALOGA IN PROTEINE
  申请人：Max-Planck-Gesellschaft zur Förderungder Wissenschaften e.V.

  公开号：EP0998487A2

  公开（公告）日：2000-05-10
• NOUVEAUX LIGANDS MULTIMERIQUES DE CD40, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION POUR LA PREPARATION DE MEDICAMENTS
  申请人：Centre National de la Recherche Scientifique

  公开号：EP1828240A2

  公开（公告）日：2007-09-05