Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them
申请人:——
公开号:US20020037931A1
公开(公告)日:2002-03-28
New compounds of formula I are described:
1
The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
IMPROVED METHOD FOR DEMETHYLATION OF NITRO- CATECHOL METHYL ETHERS
作者:David A. Learmonth、Paula C. Alves
DOI:10.1081/scc-120002413
日期:2002.1.1
Several nitro-catechol compounds. useful as inhibitors of COMT were obtained in excellent yield and purity via an improved procedure for demethylation of the corresponding methyl ethers using aluminium chloride and pyridine in ethyl acetate.
[EN] SUBSTITUTED NITRATED CATECHOLS, THEIR USE IN THE TREATMENT OF SOME CENTRAL AND PERIPHERAL NERVOUS SYSTEM DISORDERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] CATECHINES NITREES SUBSTITUEES, LEUR UTILISATION DANS LE TRAITEMENT D'AFFECTIONS DU SYSTEME NERVEUX CENTRAL ET PERIPHERIQUE ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
申请人:PORTELA & CA SA
公开号:WO2001098250A1
公开(公告)日:2001-12-27
New compounds of formula (I) are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
Schrobsdorff, Chemische Berichte, 1903, vol. 36, p. 2938