2-(4-chlorophenyl)succinic acid diethyl ester | 108005-48-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-chlorophenyl)succinic acid diethyl ester
• 英文别名: 1,4-diethyl 2-(4-chlorophenyl)butanedioate；Diethyl 2-(4-chlorophenyl)butanedioate
• CAS: 108005-48-7
• 化学式: C₁₄H₁₇ClO₄
• 分子量: 284.74
• InChiKey: OKFRLPHKPXFFBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-chlorophenyl)succinic acid diethyl ester 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 生成 3-(4-氯苯基)丙酸
  参考文献：
  名称：

  Electronic effects in solvolysis reactions. III. Solvolysis of allyl-substituted cumyl derivatives

  摘要：

  DOI：

  10.1021/jo00831a013
• 作为产物：
  描述：

  对氯苯乙腈 在 palladium on activated charcoal 硫酸 、 氢气 、 potassium carbonate 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 90.0h， 生成 2-(4-chlorophenyl)succinic acid diethyl ester
  参考文献：
  名称：

  Design, Synthesis, and Evaluation of Metabolism-Based Analogues of Haloperidol Incapable of Forming MPP+-like Species

  摘要：

  The long-term, irreversible, Parkinsonism-like side effects of haloperidol have been speculated to involve several mechanisms. More recently, it has been speculated that the metabolic transformation to MPP+-like species may contribute to the Parkinsonism-like side effects. Because BCPP+ and its reduced analogue have been shown to possess the potential to destroy dopamine receptors in the nigrostriatum, we have designed new analogues of haloperidol lacking the structural features necessary to form neurotoxic quaternary species but retaining their dopamine-binding capacity. The most potent agent at the D2 receptor, the homopiperidine analogue 11, was found to be equipotent to haloperidol. It was also of interest to identify analogues with DA binding profiles similar to that of clozapine at the dopamine receptor subtypes. Evaluation of the proposed agents shows that the ratio of D2 to D4 (2) binding of clozapine was mimicked by 7 [K-i(D2) = 33, K-i(D3) = 200, K-i(D4) = 11 nM; K-i(D2)/K-i(D4) = 3] and 9 [K-i(D2) = 44, K-i(D3) = 170, K-i(D4) = 24 nM; K-i(D2)/K-i(D4) = 2]. A preliminary in-vivo testing of compound 7 shows that its behavioral profile is similar to that of clozapine. This profile suggests that there is a need for further evaluation of these two synthetic agents and their enantiomers for efficacy and lack of catalepsy in animal models.

  DOI：

  10.1021/jm0301033

文献信息

• Practical Synthesis of Diethyl Phenylsuccinate by Mg-promoted Carboxylation of Ethyl Cinnamate
  作者：Hirofumi Maekawa、Taro Murakami、Takeshi Miyazaki、Ikuzo Nishiguchi

  DOI：10.1246/cl.2011.368

  日期：2011.4.5

  Mg-promoted reduction of ethyl cinnamate (1a) in the presence of carbon dioxide gave a mixture of β-carboxylated compound 2a and α,β-dicarboxylated compound 3a. Similar reductive carboxylation of 1...

  在二氧化碳存在下，Mg 促进肉桂酸乙酯 (1a) 的还原得到 β-羧化化合物 2a 和 α,β-二羧化化合物 3a 的混合物。1的类似还原羧化...
• Reductive Arylation of Maleic and Fumaric Acid Derivatives by Arenediazonium and Titanium(III) Salts
  作者：Attilio Citterio、Alberto Cominelli、Francesco Bonavoglia

  DOI：10.1055/s-1986-31593

  日期：——

  The titanium(III)-induced decomposition of substituted benzenediazonium salts in the presence of maleic and furamic acids, alkyl esters, amides, and nitriles gives the corresponding arylsuccinic acid derivatives.

  在马来酸和富拉酸、烷基酯、酰胺和腈的存在下，钛（III）诱导取代的苯偶氮盐分解，产生相应的芳基丁二酸衍生物。
• SOLID TITANIUM CATALYST COMPONENT, OLEFIN POLYMERIZATION CATALYST, AND OLEFIN POLYMERIZATION METHOD
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2206731A1

  公开（公告）日：2010-07-14

  The present invention provides an olefin polymerization catalyst, which is free of polyfunctional aromatic compounds and has a large particle diameter, and a solid titanium component (I) which forms the catalyst. The olefin polymerization catalyst comprises a solid titanium component (I), an organometallic compound (II) and optionally an electron donor (III) wherein the solid titanium component (I) comprising titanium, magnesium and halogen is obtainable by allowing a magnesium compound (A) having no reducing ability in a liquid state to contact with an ester compound (B) represented by the following formula (1) and a liquid titanium compound (C) in a specific order, wherein R2 and R3 are COOR1 or R, and at least one of R2 and R3 is COOR1, two or more R1 each are a monovalent hydrocarbon group having 1 to 20 carbon atoms, and two or more R are a hydrogen atom, or a hydrocarbon group having 1 to 20 carbon atoms, and at least two of Rs may be bonded each other to form a ring, and the skeleton of the ring formed may include a double bond or a hetero atom.

  本发明提供了一种烯烃聚合催化剂，该催化剂不含多官能团芳香族化合物且具有较大的颗粒直径，还提供了构成该催化剂的固体钛组分（I）。烯烃聚合催化剂由固体钛组分（I）、有机金属化合物（II）和可选的电子供体（III）组成，其中由钛、镁和卤素组成的固体钛组分（I）可通过使液态无还原能力的镁化合物（A）与下式（1）表示的酯化合物（B）和液态钛化合物（C）按特定顺序接触而获得、 其中 R2 和 R3 为 COOR1 或 R，且 R2 和 R3 中至少有一个为 COOR1，两个或两个以上的 R1 各为具有 1 至 20 个碳原子的单价烃基，两个或两个以上的 R 为氢原子，或具有 1 至 20 个碳原子的烃基，且至少两个 R 可相互键合形成环，所形成的环的骨架可包括双键或杂原子。
• SOLID TITANIUM CATALYST COMPONENT FOR ETHYLENE POLYMERIZATION, ETHYLENE POLYMERIZATION CATALYST AND ETHYLENE POLYMERIZATION METHOD
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2264075A1

  公开（公告）日：2010-12-22

  Provided are a solid titanium catalyst component for ethylene polymerization which can polymerize ethylene at a high activity and which can provide an ethylene polymer having an excellent particle property, an ethylene polymerization catalyst and an ethylene polymerization method in which the catalyst is used. The solid titanium catalyst component (I) for ethylene polymerization according to the present invention is obtained by bringing a liquid magnesium compound (A) including a magnesium compound, an electron donor (a) having 1 to 5 carbon atoms and an electron donor (b) having 6 to 30 carbon atoms into contact with a liquid titanium compound (C) under the presence of an electron donor (B) and includes titanium, magnesium and a halogen. The ethylene polymerization catalyst of the present invention includes the component (I) and an organic metal compound catalyst component (II). Further, the ethylene polymerization method of the present invention is a method for polymerizing ethylene under the presence of the catalyst.

  本发明提供了一种乙烯聚合用固体钛催化剂组分、乙烯聚合催化剂和使用该催化剂的乙烯聚合方法，该乙烯聚合用固体钛催化剂组分能以高活性聚合乙烯，并能提供具有优异颗粒性能的乙烯聚合物。 根据本发明的乙烯聚合用固体钛催化剂组分（I）是在电子供体（B）存在的情况下，将包括镁化合物、具有 1 至 5 个碳原子的电子供体（a）和具有 6 至 30 个碳原子的电子供体（b）的液态镁化合物（A）与液态钛化合物（C）接触而得到的，液态钛化合物（C）包括钛、镁和卤素。本发明的乙烯聚合催化剂包括组分（I）和有机金属化合物催化剂组分（II）。此外，本发明的乙烯聚合方法是一种在催化剂存在下聚合乙烯的方法。
• PROPYLENE RESIN COMPOSITION FOR RETORT POUCH-PACKAGING FILM
  申请人：Basell Poliolefine Italia S.r.l.

  公开号：EP2905309A1

  公开（公告）日：2015-08-12

  An object of the present invention is to provide a propylene resin composition having high processability to stably produce films, and a sealant film for retort pouch-packaging films prepared with the propylene resin composition and having high seal strength. The object is achieved by a propylene resin composition, comprising: a propylene homopolymer, and a propylene-ethylene copolymer dispersed in the propylene homopolymer, the propylene resin composition being prepared through polymerization of propylene and ethylene in the presence of a catalyst comprising: (A) a solid catalyst containing, as essential components, magnesium, titanium, halogen, and an electron donor selected from succinate type compounds, (B) an organoaluminum compound; and (C) an external electron donor selected from silicon compounds, wherein the propylene resin composition contains 25 to 35 wt% ethylene-propylene copolymer, the copolymer contains 60 wt% or more propylene, the propylene resin composition contains a xylene-soluble content having an intrinsic viscosity [η] of 1.8 to 3.2 dl/g, and the propylene resin composition has a melt flow rate of 2.0 to 5.0 g/10 min.

  本发明的目的是提供一种丙烯树脂组合物，该组合物具有较高的加工性，可以稳定地生产薄膜，还提供一种密封膜，该密封膜用于用该丙烯树脂组合物制备的蒸馏袋包装膜，具有较高的密封强度。上述目的是通过一种丙烯树脂组合物实现的，该组合物包括：丙烯均聚物和分散在丙烯均聚物中的丙烯-乙烯共聚物，丙烯树脂组合物是通过丙烯和乙烯在催化剂存在下的聚合反应制备的，催化剂包括： (A) 固体催化剂，其基本成分包括镁、钛、卤素和选自琥珀酸类化合物的电子供体、 (B) 有机铝化合物；以及 (C) 选自硅化合物的外部电子供体，其中丙烯树脂组合物含有 25 至 35 wt% 的乙烯-丙烯共聚物、 该共聚物含有 60 wt%或更多的丙烯、 丙烯树脂组合物含有本征粘度[η]为 1.8 至 3.2 dl/g 的二甲苯可溶物，以及 丙烯树脂组合物的熔体流动速率为 2.0 至 5.0 克/10 分钟。