4-tert-butylphenyl 3-methylphenyl ether | 1313735-00-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-tert-butylphenyl 3-methylphenyl ether
• 英文别名: 1-Tert-butyl-4-(3-methylphenoxy)benzene
• CAS: 1313735-00-0
• 化学式: C₁₇H₂₀O
• 分子量: 240.345
• InChiKey: RZMMRCXFZUHJMC-UHFFFAOYSA-N

物化性质

• 沸点：
  323.485±11.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  0.989±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-叔丁基苯酚 、 间碘甲苯 在 copper(l) iodide 、 C₃₇H₅₆N₄O₄ 、 caesium carbonate 作用下， 以 乙二醇二甲醚 为溶剂， 反应 20.0h， 以81%的产率得到4-tert-butylphenyl 3-methylphenyl ether
  参考文献：
  名称：

  N,N'-二氧化物-铜 (I) 催化体系催化芳基卤化物与胺、酚和硫醇的交叉偶联反应

  摘要：

  通过使用新型手性 N,N'-二氧化物-铜 (I) 催化体系作为催化剂，各种 N、O 和 S 亲核试剂与芳基卤化物的偶联反应已在温和条件下成功进行。这种多功能且高效的催化剂体系已被证明可促进芳基卤化物与胺、酚和硫醇的交叉偶联反应，从而以良好至极好的收率提供相应的所需产物。

  DOI：

  10.1002/ejoc.201100274

文献信息

• HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS
  申请人：BENTZIEN Joerg Martin

  公开号：US20140045813A1

  公开（公告）日：2014-02-13

  The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.

  本发明涵盖了以下式（I）的化合物： 其中A、Cy、X1和Y团在此处定义，适用于治疗与BTK相关的疾病，包括制备过程、含有化合物的药物制剂以及它们的使用方法。
• Heteroaromatic compounds as BTK inhibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：US10875852B2

  公开（公告）日：2020-12-29

  The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.

  本发明包括式 (I) 的化合物 其中基团 A、Cy、X1 和 Y 在本文中定义，适用于治疗与 BTK 有关的疾病、制造工艺、含有化合物的药物制剂及其使用方法。
• Fungicide N-Cyclopropyl-Sulfonylamide Derivatives
  申请人：Schwarz Hans-Georg

  公开号：US20090137611A1

  公开（公告）日：2009-05-28

  The present invention relates to N-cyclopropyl-sulfonylamide derivatives of formula (I) wherein the substituents are cyclic groups, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions: (I)
• Inhibitors of Cyclin Kinase Inhibitor p21
  申请人：Weiss Robert

  公开号：US20110301192A1

  公开（公告）日：2011-12-08

  The present invention provides compounds that inhibit cyclin kinase inhibitor p21, such as compounds of formula I. The present invention also provides compositions including compounds of Formula I and a pharmaceutically acceptable excipient. In addition, the present invention provides methods of inhibiting cyclin kinase inhibitor p21 and of treating cancer.
• POLYIMIDE POLYMER SOLUTION, POLYIMIDE POLYMER, TRANSPARENT FILM, DISPLAYING DEVICE AND SOLAR CELL
  申请人：Leu Chyi-Ming

  公开号：US20120160317A1

  公开（公告）日：2012-06-28

  A polyimide polymer solution, a polyimide polymer, a transparent film, a display device and a solar cell are provided. The polyimide polymer has at least one of a repeating unit of formula (D) and a repeating unit of formula (J) and at least one of a repeating unit of formula (Q) and a repeating unit of formula (T). One of B and B′ is cyclo-aliphatic compound, and the other is aromatic compound, a molar mass ratio of the cyclo-aliphatic compound to the aromatic compound is 1˜4 , A and A′ are identical or different aromatic diamines, and at least one of A and A′ is aromatic diamine with ether groups, and A could be the same as or different from A′.