(E)-2-(2,3-dimethoxystyryl)benzothiazole | 141838-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-2-(2,3-dimethoxystyryl)benzothiazole
• 英文别名: 2-(2,3-dimethoxy-styryl)-benzothiazole；2-(2,3-Dimethoxy-styryl)-benzothiazol；2-[(E)-2-(2,3-dimethoxyphenyl)ethenyl]-1,3-benzothiazole
• CAS: 141838-86-0
• 化学式: C₁₇H₁₅NO₂S
• 分子量: 297.378
• InChiKey: PVSMXTKHLZJWPZ-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-2-(2,3-dimethoxystyryl)benzothiazole 在 氢碘酸 、 溶剂黄146 作用下， 生成 3-(2-benzothiazol-2-yl-vinyl)-pyrocatechol
  参考文献：
  名称：

  Notes - Methoxy-and-Hydroxy-styryl Heterocycles

  摘要：

  DOI：

  10.1021/jo01111a614
• 作为产物：
  描述：

  2-甲基苯并噻唑 、 2,3-二甲氧基苯甲醛 在 sodium hydroxide 、 苄基三乙基氯化铵 作用下， 反应 14.0h， 以69%的产率得到(E)-2-(2,3-dimethoxystyryl)benzothiazole
  参考文献：
  名称：

  Lokhande, S. B.; Rangnekar, D. W., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1986, vol. 25, p. 485 - 488

  摘要：

  DOI：

文献信息

• Cytotoxic anionic tribromo platinum(II) complexes containing benzothiazole and benzoxazole donors: synthesis, characterization, and structure-activity correlation
  作者：César M. Lozano、Osvaldo Cox、Mariel M. Muir、Johara D. Morales、Jorge L. Rodríguez-Cabán、Pablo E. Vivas-Mejía、Fernando A. Gonzalez

  DOI：10.1016/s0020-1693(97)05952-5

  日期：1998.4

  A series of platinum(II) complexes of the type [NEt4][PtLBr3] where L is a 2-styrylbenzothiazole or 2-styrylbenzoxazole was prepared. The complexes were characterized by their melting points, elemental analyses, W-Vis and far-infrared spectra, and H-1 and Pt-195 NMR spectroscopy. The NMR data are consistent with coordination of the benzoheterazole ligands to the Pt ion through the nitrogen atom. The ligands and the complexes were assayed for cytotoxicity against U937 human histiocytic lymphoma cells. It was observed that the ligands displayed very poor cytotoxicity, while the Pt(II) complexes demonstrated marked cytotoxicities and a structure-activity correlation was established. Pt(ll) complexes containing S as the heteroatom in the benzoheterazole ring were generally more active than their O-containing counterpart. The position and type of substituents in the styryl moiety were also important for biological activity. Our data indicate that adjacent methoxy functionalities were present in the most potent drugs tested. Further development of active Pt(II) complexes with improved solubilities is warranted. (C) 1998 Elsevier Science S.A.
• LOKHANDE S. B.; RANGNEKAR D. W., INDIAN J. CHEM., 25,(1986) N 5, 485-488
  作者：LOKHANDE S. B.、 RANGNEKAR D. W.

  DOI：——

  日期：——
• Lokhande, S. B.; Rangnekar, D. W., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1986, vol. 25, p. 485 - 488
  作者：Lokhande, S. B.、Rangnekar, D. W.

  DOI：——

  日期：——
• Notes - Methoxy-and-Hydroxy-styryl Heterocycles
  作者：H. Gilman、J. Towle、R. Ingham

  DOI：10.1021/jo01111a614

  日期：1956.5