N-methyl-N-[(4-methylphenyl)diazenyl]methanamine | 7203-89-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-N-[(4-methylphenyl)diazenyl]methanamine
• 英文别名: 3,3-dimethyl-1-(4-methylphenyl)triazene
• CAS: 7203-89-6
• 化学式: C₉H₁₃N₃
• 分子量: 163.222
• InChiKey: PSNZDNVJMNLFKA-ZHACJKMWSA-N

物化性质

• 熔点：
  49-51 °C(lit.)
• 沸点：
  231.3±33.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  12.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  27.96
• 氢给体数：
  0.0
• 氢受体数：
  2.0

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22,S26,S36/37/39,S45
• 危险类别码：
  R20/21/22,R40

反应信息

• 作为反应物：
  描述：

  N-methyl-N-[(4-methylphenyl)diazenyl]methanamine 在 正丁基锂 、 水 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 以95%的产率得到N,3-二甲基苄胺
  参考文献：
  名称：

  Formation of benzylamines from triazene compounds via a 1,2-proton shift

  摘要：

  A new approach to benzylamines using triazene compounds has been developed that is facilitated by the lithiation of aryltriazenes followed by treatment with an electrophile. The regioselectivity of the reaction can be controlled by means of the substituents in the aryl group. The reaction contains the following steps: intramolecular carbon-carbon bond formation involving lithiation of an alkyl group on a 3-nitrogen atom; a 1,2-proton shift; and the subsequent release of nitrogen gas. Through the use of a deuterated triazene, we were able to determine that the reaction proceeds through a 1,2-proton shift. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.04.063

文献信息

• [EN] MICROCAPSULES CONTAINING A GAS-RELEASING PHOTOLABILE COMPOUND AND USES THEREOF<br/>[FR] MICROCAPSULES CONTENANT UN COMPOSE PHOTOLABILE DE LIBÉRATION DE GAZ, ET LEURS UTILISATIONS
  申请人：FIRMENICH & CIE

  公开号：WO2014187874A1

  公开（公告）日：2014-11-27

  The present invention relates to water-dispersible microcapsules comprising an oil phase, e.g. a perfume, containing a photolabile compound capable of generating a gas upon exposure to light. The gas is able to cause an extension or the breaking of the microcapsule allowing the release of the oil phase and thus increasing the long-lastingness of the odor perception. The present invention concerns also the use of said microcapsules in perfumery as well as the perfuming compositions or perfumed articles comprising the invention's microcapsules to provide a prolonged release of fragrant molecules.

  本发明涉及水分散微胶囊，包括油相，例如香水，其中含有能够在光照作用下产生气体的光敏化合物。该气体能够引起微胶囊的延展或破裂，从而释放油相，从而增加气味感知的持久性。本发明还涉及在香水中使用所述微胶囊，以及包含本发明微胶囊的香水组合物或香水制品，以提供芳香分子的持续释放。
• Fluorination of aromatic compounds from 1-aryl-3,3-dimethyltriazenes and fluoride anions in acidic medium
  作者：Thierry Pages、Bernard R. Langlois

  DOI：10.1016/s0022-1139(00)00376-6

  日期：2001.2

  Decomposition of 1-aryl-3,3-dialkyltriazenes by strong and non-nucleophilic acids (CF3SO3H, H2SO4) can be achieved at 90°C in carbon tetrachloride, in the presence of sub-stoichiometric amounts of fluoride anions. Yields of fluoroarenes up to 39% (versus F−) can be reached under these conditions, within 15–30 min and without contamination of the fluorinated compounds by inseparable by-products. Such

  在亚化学计量量的四氯化碳存在下，可以在90°C下于四氯化碳中，通过强和非亲核酸（CF 3 SO 3 H，H 2 SO 4）分解1-芳基-3,3-二烷基三氮烯。氟阴离子。fluoroarenes高达39％的产率（相对于˚F - ）可以在这些条件下，通过不可分离的副产物即可到达，内15-30分钟并且没有氟化合物的污染。在这样的条件和结果使一种适应放射性氟化以18 ˚F - 。
• [EN] THERAPEUTIC CONJUGATES<br/>[FR] CONJUGUÉS THÉRAPEUTIQUES
  申请人：ARIEL SCIENT INNOVATIONS LTD

  公开号：WO2020121304A1

  公开（公告）日：2020-06-18

  Provided herein is a class of anti-cancer conjugates designed to cross the blood-brain barrier (BBB) and thereby deliver a methylation agent into cancerous tumor cells, wherein the conjugate comprises a BBB-shuttle moiety that allows the conjugate to cross the BBB, and at least two methylation moieties of the methyltriazene type attached thereto for effecting DNA methylation in the cancerous cells. Also provided are uses of the conjugates in the treatment of brain cancer.

  本文提供了一类抗癌结合物，旨在穿过血脑屏障（BBB），并将甲基化剂传递到癌症肿瘤细胞中。其中，该结合物包括一种BBB穿梭基团，使结合物能够穿过BBB，并至少附着有两个甲基三氮烯型甲基化基团，以在癌细胞中实现DNA甲基化作用。同时，本文还提供了该结合物在治疗脑癌中的用途。
• MICROCAPSULES CONTAINING A GAS-RELEASING PHOTOLABILE COMPOUND AND USES THEREOF
  申请人：FIRMENICH SA

  公开号：US20160120773A1

  公开（公告）日：2016-05-05

  The present invention relates to water-dispersible microcapsules that include an oil phase, e.g. a perfume, containing a photolabile compound capable of generating a gas upon exposure to light. The gas is able to cause an extension or the breaking of the microcapsule allowing the release of the oil phase and thus increasing the long-lastingness of the odor perception. The present invention concerns also the use of such microcapsules in perfumery as well as the perfuming compositions or perfumed articles that include such microcapsules therein to provide a prolonged release of fragrant molecules.

  本发明涉及一种水分散微囊，其中包含一种油相，例如香水，其中含有一种光敏化合物，能够在光照下产生气体。该气体能够引起微囊的扩展或破裂，释放油相，从而增加气味感知的持久性。本发明还涉及在香水中使用这种微囊的方法，以及包含这种微囊的香料组合物或香味物品，以提供香气分子的持久释放。
• Composition for film formation, method of film formation, and silica-based film
  申请人：JSR Corporation

  公开号：EP1148105A2

  公开（公告）日：2001-10-24

  A composition for film formation which comprises: (A) a product of hydrolysis and condensation obtained by hydrolyzing and condensing at least one compound selected from the group consisting of (A-1) compounds represented by the following formula (1)         RaSi(OR1)4-a     (1) (A-2) compounds represented by the following formula (2)         Si(OR2)4     (2) and (A-3) compounds represented by the following formula (3)         R3 b (R4O) 3-bSi-(R7)d-Si (OR5)3-cR6 c     (3) (B) at least one member selected from the group consisting of compounds of the metals in Groups IA and IIA of the periodic table; and (C) an organic solvent. A method for film formation using the composition and a silica-based film obtained by the method are also disclosed.

  一种用于成膜的组合物，包括 (A) 通过水解和缩合至少一种选自以下组别的化合物而得到的水解和缩合产物 (A-1) 下式（1）所代表的化合物 RaSi(OR1)4-a (1) (A-2) 下式（2）所代表的化合物 Si(OR2)4 (2) 和 (A-3) 下式(3)所代表的化合物 R3 b (R4O) 3-bSi-(R7)d-Si (OR5)3-cR6 c (3) (B) 至少一个选自元素周期表第 IA 和 IIA 族金属化合物的成员；以及 (C) 有机溶剂。 此外，还公开了使用该组合物形成薄膜的方法以及通过该方法获得的硅基薄膜。