4-butyl-thiazolidine-2-thione | 61522-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 4-butyl-thiazolidine-2-thione
• 英文别名: 4-Butylthiazolidin-2-thion；4-Butyl-1,3-thiazolidine-2-thione
• CAS: 61522-38-1
• 化学式: C₇H₁₃NS₂
• 分子量: 175.319
• InChiKey: WXAIIZDPDDPGQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-butyl-thiazolidine-2-thione 、 trimethoxonium tetrafluoroborate 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

  摘要：

  Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.033
• 作为产物：
  描述：

  1-己烯 、 dirhodane 生成 4-butyl-thiazolidine-2-thione
  参考文献：
  名称：

  Thiocyanations. 4. Cyclization of 1-isothiocyanato-2-thiocyanates. A stereospecific route to the preparation of 4,5-thiazolidine-2-thiones

  摘要：

  DOI：

  10.1021/jo00429a007

文献信息

• MAXWELL R. J.; MOORE G. G.; SILBERT L. S., J. ORG. CHEM. <JOCE-AH>, 1977, 42, NO 9, 1517-1520
  作者：MAXWELL R. J.、 MOORE G. G.、 SILBERT L. S.

  DOI：——

  日期：——
• Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase
  作者：K Shankaran、Karla L Donnelly、Shrenik K Shah、Ravindra N Guthikonda、Malcolm MacCoss、John L Humes、Stephen G Pacholok、Stephan K Grant、T.M Kelly、K.K Wong

  DOI：10.1016/j.bmcl.2004.06.033

  日期：2004.9

  Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity. (C) 2004 Elsevier Ltd. All rights reserved.
• Thiocyanations. 4. Cyclization of 1-isothiocyanato-2-thiocyanates. A stereospecific route to the preparation of 4,5-thiazolidine-2-thiones
  作者：Robert J. Maxwell、Gordon G. Moore、Leonard S. Silbert

  DOI：10.1021/jo00429a007

  日期：1977.4