TSe-G1-(OH)2 | 1131064-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: TSe-G1-(OH)2
• 英文别名: 2-(4-Methylphenyl)sulfonylethyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate；2-(4-methylphenyl)sulfonylethyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
• CAS: 1131064-60-2
• 化学式: C₁₄H₂₀O₆S
• 分子量: 316.375
• InChiKey: VLDZJEVRYGSMRL-UHFFFAOYSA-N

物化性质

• 沸点：
  549.3±50.0 °C(Predicted)
• 密度：
  1.290±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  TSe-G1-(OH)2 在 吡啶 、 4-二甲氨基吡啶 、 10 wt% Pd(OH)2 on carbon 、 氢气 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N'-二环己基碳二亚胺 、 DPTS 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 20.0 ℃ 、1.0 MPa 条件下， 反应 66.0h， 生成 3-[3-(2-Ethoxycarbothioylsulfanylacetyl)oxy-2-[(2-ethoxycarbothioylsulfanylacetyl)oxymethyl]-2-methylpropanoyl]oxy-2-[[3-(2-ethoxycarbothioylsulfanylacetyl)oxy-2-[(2-ethoxycarbothioylsulfanylacetyl)oxymethyl]-2-methylpropanoyl]oxymethyl]-2-methylpropanoic acid
  参考文献：
  名称：

  The first peripherally masked thiol dendrimers: a facile and highly efficient functionalization strategy of polyester dendrimers via one-pot xanthate deprotection/thiol–acrylate Michael addition reactions

  摘要：

  我们提出了第一种黄羧酸酯表面功能性树状聚合物，可以快速进行一锅法去保护生成硫醇，然后进行丙烯酸酯迈克尔加成。

  DOI：

  10.1039/c3cc49704f
• 作为产物：
  描述：

  亚苄基-2,2-双(氧基甲基)丙酸 在 吡啶 、 4-二甲氨基吡啶 、 10 wt% Pd(OH)2 on carbon 、 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 20.0 ℃ 、1.0 MPa 条件下， 反应 58.0h， 生成 TSe-G1-(OH)2
  参考文献：
  名称：

  The first peripherally masked thiol dendrimers: a facile and highly efficient functionalization strategy of polyester dendrimers via one-pot xanthate deprotection/thiol–acrylate Michael addition reactions

  摘要：

  我们提出了第一种黄羧酸酯表面功能性树状聚合物，可以快速进行一锅法去保护生成硫醇，然后进行丙烯酸酯迈克尔加成。

  DOI：

  10.1039/c3cc49704f

文献信息

• Synthesis of Polyester Dendritic Scaffolds for Biomedical Applications
  作者：Lukas P. Sadowski、Patricia E. Edem、John F. Valliant、Alex Adronov

  DOI：10.1002/mabi.201600154

  日期：2016.10

  Using a well‐defined poly(2,2‐bis(hydroxymethyl)propanoic acid) dendrimer scaffold, a series of G1 to G3 dendrons is functionalized at the periphery with alkynes to enable “Click” functionalization via the copper‐catalyzed alkyne–azide cycloaddition (CuAAC). The resulting dendrons are further functionalized at the core with a dipicolylamine (DPA) moiety to enable radiolabeling with 99mTc for molecular

  使用定义明确的聚（2,2-双（羟甲基）丙酸）树状聚合物骨架，一系列G1至G3树突在炔烃的外围进行官能化，以通过铜催化炔烃-叠氮化物环加成反应实现“点击”官能化（CuAAC）。生成的树突在核心处用二聚烯丙基胺（DPA）进一步功能化，从而能够在分子成像应用中用99m Tc进行放射性标记。使用叠氮化物官能化的三乙二醇单甲醚（TEG-N 3）可实现有效的CuAAC偶联。在用99m Tc进行放射性标记之前，已成功在G1和G2树状聚合物上完成了从DPA配体中去除铜的操作。G3树状大分子的放射性标记是通过[CuDPA] 2+的金属转移来完成的Tm为99m Tc的配体，进一步证明了合成策略在制备树突显像剂中的可行性。随后探讨了用于组织蛋白酶B靶向的酰氧基甲基酮（AOMK）衍生物的后续连接。尽管显示了连接多个AOMK配体的能力，但AOMK-树状聚合物结合物不能与组织蛋白酶B结合，这可能归因于树状聚合物外围的空间位阻。
• [EN] POLYDENDRONS<br/>[FR] POLYDENDRONS
  申请人：UNIV LIVERPOOL

  公开号：WO2014199174A1

  公开（公告）日：2014-12-18

  A method of preparing a non-gelled branched vinyl polymer scaffold carrying dendrons, comprising the living or controlled polymerization of a monofunctional vinyl monomer and a difunctional vinyl monomer, using a dendron initiator and at least one further initiator.

  一种制备携带树枝状分子的非凝胶化支化乙烯聚合物支架的方法，包括对单官能乙烯单体和双官能乙烯单体进行活性或受控聚合，使用树枝状引发剂和至少一种进一步引发剂。
• AB3 building blocks for the synthesis of polyester dendrimers
  作者：Jean-d’Amour K. Twibanire、Malcolm P. Huestis、T. Bruce Grindley

  DOI：10.1016/j.tetlet.2014.04.073

  日期：2014.6

  Syntheses of several examples of a new type of trivalent building blocks for the preparation of aliphatic polyester dendrimers are presented. Starting from the well-known mono-O-benzylidenepentaerythritol, AB3 type acid dendrons can be obtained in high yield in only two steps. Other triprotected bis-2,2-(hydroxymethyl)-3-hydroxypropanoic acid derivatives with varying protecting groups were also synthesized

  提出了用于制备脂族聚酯树枝状聚合物的新型三价结构单元的几个实例的合成。从众所周知的单-O-亚苄基季戊四醇开始，仅需两个步骤就可以高收率获得AB 3型酸性树突。具有不同保护基的其他三保护的双-2，2-（羟甲基）-3-羟基丙酸衍生物也很容易合成。将这种树状体与2,2'-双（羟甲基）丙酸（bis-HMPA）二价树状体结合使用，可生产出具有更高支化点数的低代混合聚酯树状体。
• Parrott, Matthew C.; Benhabbour, S. Rahima; Saab, Chantal, Journal of the American Chemical Society, 2009, vol. 131, p. 2906 - 2916
  作者：Parrott, Matthew C.、Benhabbour, S. Rahima、Saab, Chantal、Lemon, Jennifer A.、Parker, Shannon、et al.

  DOI：——

  日期：——
• Interactions of carbon nanotubes with pyrene-functionalized linear-dendritic hybrid polymers
  作者：Greg J. Bahun、Alex Adronov

  DOI：10.1002/pola.23855

  日期：2010.3.1

  AbstractA series of linear‐dendritic hybrid polymers, containing pyrene units at the periphery of aliphatic polyester dendrons, were prepared for the purpose of dispersing shortened single‐walled carbon nanotubes (SWNTs) in tetrahydrofuran (THF). The prepared hybrids contained 1, 2, 4, 8, or 16 (G0 through G4) pyrene units and a linear segment composed of polystyrene. It was found that a minimum of four pyrene units was necessary to form a strong enough interaction with SWNTs to enable steric stabilization in solution, when using a linear polymer segment of 11.5 kDa. Increasing either the number of pyrene units per polymer chain or the length of the polymer segment to 18.0 kDa did not improve nanotube solubility, whereas decreasing the polymer length resulted in significantly less effective nanotube dissolution. The G4 dendron alone, without the linear polystyrene segment, was also found to impart solubility to the nanotubes in THF. Interactions between the series of linear‐dendritic hybrids and full‐length multiwalled carbon nanotubes were also investigated, and it was found that the polymers exhibited strong interactions with the multiwalled carbon nanotube surface, resulting in the formation of stable solutions. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 1016–1028, 2010