2-amino-7-methoxy-4-methylquinazoline | 171003-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-amino-7-methoxy-4-methylquinazoline
• 英文别名: 7-Methoxy-4-methylquinazolin-2-amine
• CAS: 171003-73-9
• 化学式: C₁₀H₁₁N₃O
• 分子量: 189.217
• InChiKey: SWCIWAJITWQHBP-UHFFFAOYSA-N

物化性质

• 沸点：
  412.1±37.0 °C(Predicted)
• 密度：
  1.240±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氯-4-甲氨基嘧啶 、 2-amino-7-methoxy-4-methylquinazoline 在 tris-(dibenzylideneacetone)dipalladium(0) 、 caesium carbonate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 四氢呋喃 为溶剂， 反应 14.0h， 以31%的产率得到N²-(7-methoxy-4-methylquinazolin-2-yl)-N⁴-methylpyrimidine-2,4-diamine
  参考文献：
  名称：

  WO2020099650A5

  摘要：

  公开号：

  WO2020099650A5
• 作为产物：
  描述：

  2-氟-4-甲氧基苯乙酮 、 碳酸胍 以 N,N-二甲基乙酰胺 为溶剂， 反应 6.0h， 以65%的产率得到2-amino-7-methoxy-4-methylquinazoline
  参考文献：
  名称：

  Hynes, John B.; Campbell, Johnny P.; Hynes, John D., Journal of Heterocyclic Chemistry, 1995, vol. 32, # 4, p. 1185 - 1188

  摘要：

  DOI：

文献信息

• MADRASIN-DERIVATIVE COMPOUNDS, COMPOSITION AND USES THEREOF FOR TREATING CANCER
  申请人：Institut Gustave-Roussy

  公开号：EP3880205A1

  公开（公告）日：2021-09-22
• [EN] MADRASIN-DERIVATIVE COMPOUNDS, COMPOSITION AND USES THEREOF FOR TREATING CANCER<br/>[FR] COMPOSÉS DÉRIVÉS DE MADRASINE, COMPOSITION ET LEURS UTILISATIONS POUR TRAITER LE CANCER
  申请人：ROUSSY INST GUSTAVE

  公开号：WO2020099650A1

  公开（公告）日：2020-05-22

  The present invention relates to the fields of medicine and in particular cancer treatment. The invention more specifically relates to new compounds which are typically for use as a medicament. In particular, the invention relates to the use of these new compounds for increasing the presentation, typically the production and presentation, of Pioneer Translation Products (PTPs)-derived antigens by cells, in particular cancer cells, or changing the immunopeptidome, in a subject, and inducing or stimulating an immune response in the subject. The present disclosure also relates to uses of such compounds, in particular to prepare a pharmaceutical composition and/or to allow or improve the efficiency of a therapy in a subject in need thereof. The invention also discloses methods for treating a disease, in particular cancer, for preventing or treating cancer metastasis and/or cancer recurrence, in a subject. The present invention in addition provides kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.