2,2,2-Trifluoro-1-(5-methylfuran-2-yl)ethanol | 862158-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2,2,2-Trifluoro-1-(5-methylfuran-2-yl)ethanol
• CAS: 862158-19-8
• 化学式: C₇H₇F₃O₂
• mdl: MFCD09040406
• 分子量: 180.127
• InChiKey: LSWBOGKYWKNEBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,2,2-Trifluoro-1-(5-methylfuran-2-yl)ethanol 在 2-碘酰基苯甲酸 作用下， 以 乙酸乙酯 为溶剂， 反应 15.0h， 以95%的产率得到2,2,2-三氟-1-(5-甲基-2-呋喃基)乙酮
  参考文献：
  名称：

  通过邻碘苯甲酸（IBX）高效合成芳基和杂芳基三氟甲基酮

  摘要：

  描述了由相应的醛合成芳基和杂芳基三氟甲基酮的两步法。使用催化量的K 2 CO 3由芳基和杂芳基醛以极好的收率制备三氟甲醇。然后在温和的条件下，通过邻碘氧苯甲酸（IBX）方便有效地氧化三氟甲醇，得到所需的官能化芳基和杂芳基三氟甲基酮。

  DOI：

  10.1016/j.tetlet.2013.06.045
• 作为产物：
  描述：

  5-甲基呋喃醛 在 盐酸 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 2,2,2-Trifluoro-1-(5-methylfuran-2-yl)ethanol
  参考文献：
  名称：

  Trifluoromethylation and pentafluoroethylation of terpenoid carbonyl compounds used in perfumery

  摘要：

  The reaction of trifluoromethyltrimethylsilane with a variety of terpenoid carbonyl compounds and other carbonyl compounds used in perfumery gave the corresponding trifiuoromethylated derivatives. Pentafluoroethylated compounds were similarly obtained from the reaction of pentafluoroethyltrimethylsilane with various substrates. (-)-2-Trifluoro-1-furyl ethanol has been obtained with high optical purity by enzymatic hydrolysis of 2-trifluoro-1-furyl ethyl acetate.

  DOI：

  10.1016/0022-1139(94)03204-d

文献信息

• 3,4-Di-Substituted Cyclobutene-1,2-Diones as CXC-Chemokine Receptor Ligands
  申请人：Taveras Arthur G.

  公开号：US20110213029A1

  公开（公告）日：2011-09-01

  There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

  公开了以下式的化合物，或其药学上可接受的盐或溶剂，它们可用于治疗由趋化因子介导的疾病，如急性和慢性炎症性疾病和癌症。
• Trifluoromethylation and pentafluoroethylation of terpenoid carbonyl compounds used in perfumery
  作者：Shoji Watanabe、Tsutomu Fujita、Masami Sakamoto、Yasuhiro Mino、Tomoya Kitazume

  DOI：10.1016/0022-1139(94)03204-d

  日期：1995.7

  The reaction of trifluoromethyltrimethylsilane with a variety of terpenoid carbonyl compounds and other carbonyl compounds used in perfumery gave the corresponding trifiuoromethylated derivatives. Pentafluoroethylated compounds were similarly obtained from the reaction of pentafluoroethyltrimethylsilane with various substrates. (-)-2-Trifluoro-1-furyl ethanol has been obtained with high optical purity by enzymatic hydrolysis of 2-trifluoro-1-furyl ethyl acetate.
• Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodobenzoic acid (IBX)
  作者：Huicheng Cheng、Yu Pei、Faqiang Leng、Jingya Li、Apeng Liang、Dapeng Zou、Yangjie Wu、Yusheng Wu

  DOI：10.1016/j.tetlet.2013.06.045

  日期：2013.8

  A two-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcohols were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amount of K2CO3. The trifluoromethyl alcohols were then oxidized conveniently and efficiently by o-iodoxybenzoic acid (IBX) under mild conditions to get the desired

  描述了由相应的醛合成芳基和杂芳基三氟甲基酮的两步法。使用催化量的K 2 CO 3由芳基和杂芳基醛以极好的收率制备三氟甲醇。然后在温和的条件下，通过邻碘氧苯甲酸（IBX）方便有效地氧化三氟甲醇，得到所需的官能化芳基和杂芳基三氟甲基酮。