2,2-Dimethyl-3-phenyl-propionsaeure-isobutylester | 40548-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-Dimethyl-3-phenyl-propionsaeure-isobutylester
• 英文别名: 2,2-dimethyl-3-phenyl-propionic acid isobutyl ester；2-Methylpropyl 2,2-dimethyl-3-phenylpropanoate
• CAS: 40548-66-1
• 化学式: C₁₅H₂₂O₂
• 分子量: 234.338
• InChiKey: PBUYCYNYVXKVJZ-UHFFFAOYSA-N

物化性质

• 沸点：
  301.1±11.0 °C(Predicted)
• 密度：
  0.969±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-3-phenyl-propionsaeure-isobutylester 在 lithium aluminium tetrahydride 作用下， 生成 铃兰醇
  参考文献：
  名称：

  Conversion of 1,3-dihalopropanes to propanes and/or cyclopropanes on treatment with different reducing agents

  摘要：

  DOI：

  10.1021/jo00956a004
• 作为产物：
  描述：

  异丁酸异丁酯 、 氯化苄 生成 2,2-Dimethyl-3-phenyl-propionsaeure-isobutylester
  参考文献：
  名称：

  Conversion of 1,3-dihalopropanes to propanes and/or cyclopropanes on treatment with different reducing agents

  摘要：

  DOI：

  10.1021/jo00956a004

文献信息

• Associated Injuries Found in Chronic Lateral Ankle Instability
  作者：Benedict F. DiGiovanni、Carlos J. Fraga、Bruce E. Cohen、Michael J. Shereff

  DOI：10.1177/107110070002101003

  日期：2000.10

  Sixty-one patients underwent a primary ankle lateral ligament reconstruction for chronic instability between 1989 and 1996. In addition to the ligament reconstruction, all patients had evaluation of the peroneal retinaculum, peroneal tendon inspection by routine opening of the tendon sheath, and ankle joint inspection by arthrotomy. A retrospective review of the clinical history, physical exam, MRI examination, and intraoperative findings was conducted on these 61 patients. The purpose was to determine the type and frequency of associated injuries found at surgery and during the preoperative evaluation. At surgery no patients were found to have isolated lateral ligament injury. Fifteen different associated injuries were noted. The injuries found most often by direct inspection included: peroneal tenosynovitis, 47/61 patients (77%); anterolateral impingement lesion, 41/61 (67%); attenuated peroneal retinaculum, 33/61 (54%); and ankle synovitis, 30/61 (49%). Other less common but significant associated injuries included: intra-articular loose body, 16/61 (26%); peroneus brevis tear, 15/61 (25%); talus osteochondral lesion, 14/61 (23%); medial ankle tendon tenosynovitis, 3/61 (5%). The findings of this study indicate there is a high frequency of associated injuries in patients with chronic lateral ankle instability. Peroneal tendon and retinacular pathology, as well as anterolateral impingement lesions, occur most often. A high index of suspicion for possible associated injuries may result in more consistent outcomes with nonoperative and operative treatment of patients with chronic lateral ankle instability.

  从1989年到1996年，61名患者接受了原发性踝侧韧带重建手术，治疗慢性不稳定。除了韧带重建手术外，所有患者均进行了腓骨韧带韧带鞘常规开放检查、踝关节关节镜检查。对这61名患者的临床病史、体格检查、MRI检查和术中发现进行了回顾性分析，目的是确定手术和术前评估中发现的相关损伤类型和频率。手术中未发现任何患者存在单独的侧韧带损伤，发现了15种不同的相关损伤。直接检查发现的最常见损伤包括：腓骨韧带滑囊炎，47/61例患者（77%）；前外侧撞击损伤，41/61例（67%）；腓骨韧带韧带鞘变薄，33/61例（54%）；以及踝关节滑膜炎，30/61例（49%）。其他不太常见但显著的相关损伤包括：关节内游离体，16/61例（26%）；短腓骨肌撕裂，15/61例（25%）；距骨软骨病变，14/61例（23%）；内踝腱鞘滑囊炎，3/61例（5%）。本研究的发现表明，慢性侧踝不稳定患者存在高频率的相关损伤。腓骨韧带和韧带鞘病变以及前外侧撞击损伤最常见。对可能存在相关损伤的患者进行高度怀疑可能会导致慢性侧踝不稳定患者的非手术和手术治疗结果更加一致。
• Prodrugs for the Treatment of Schizophrenia and Bipolar Disease
  申请人：Blumberg Laura Cook

  公开号：US20110166156A1

  公开（公告）日：2011-07-07

  Compounds of Formula I and Formula II and their use for the treatment of neurological and psychiatric disorders including schizophrenia and manic or mixed episodes associated with bipolar I disorder with or without psychotic features is disclosed.

  本文披露了公式I和公式II的化合物及其用于治疗神经系统和精神障碍，包括与双相I型障碍伴有或不伴有精神症状的精神分裂症和躁狂或混合发作的治疗。
• Conversion of 1,3-dihalopropanes to propanes and/or cyclopropanes on treatment with different reducing agents
  作者：Melvin S. Newman、G. S. Cohen、Robert F. Cunico、L. W. Dauernheim

  DOI：10.1021/jo00956a004

  日期：1973.8