1-(m-chlorophenoxy)-3-(n-propyl)-2,3,4,5-tetrahydro-3-benzazepine | 89739-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 1-(m-chlorophenoxy)-3-(n-propyl)-2,3,4,5-tetrahydro-3-benzazepine
• 英文别名: 1-(3-Chlorophenoxy)-3-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine；5-(3-chlorophenoxy)-3-propyl-1,2,4,5-tetrahydro-3-benzazepine
• CAS: 89739-09-3
• 化学式: C₁₉H₂₂ClNO
• 分子量: 315.843
• InChiKey: DVOIXRDUSKIDOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(m-chlorophenoxy)-2,3,4,5-tetrahydro-3-benzazepine 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-(m-chlorophenoxy)-3-(n-propyl)-2,3,4,5-tetrahydro-3-benzazepine
  参考文献：
  名称：

  1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines

  摘要：

  该发明涉及式中Y为相同或不同的氢和较低的烷氧基；X为氢、卤素、较低的烷基、较低的烷氧基、三氟甲基、硝基、氰基和氨基；R为氢、较低的烷基、环烷基较低的烷基、Ar较低的烷基；其中Z为氢、较低的烷基、较低的烷氧基、卤素、三氟甲基、硝基和氨基；Aryloxy较低的烷基；以及药学上可接受的酸盐。

  公开号：

  US04794181A1

文献信息

• Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04935418A1

  公开（公告）日：1990-06-19

  The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same or different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF.sub.3, NO.sub.2, CN and NH.sub.2 ; R is hydrogen, lower alkyl, cycloalkyllower alkyl, ##STR2## Ar lower alkyl of the formula ##STR3## where Z is hydrogen, lower alkyl, lower alkoxy, halogen CF.sub.3, NO.sub.2 and NH.sub.2 ; Aryloxy lower alkyl of the formula ##STR4## where Z is as previously defined; and an alkylene amine of the formula ##STR5## where R.sub.1 and R.sub.2 are the same or different and are hydrogen and lower alkyl, n is an integer of 1 or 2; and the pharmaceutically acceptable acid addition salts thereof.

  本发明涉及式子##STR1##中的1-芳氧基-2,3,4,5-四氢-3-苯并哌啶；其中Y相同或不同，是氢和低级烷氧基；X是氢、卤素、低级烷基、低级烷氧基、CF.sub.3、NO.sub.2、CN和NH.sub.2；R是氢、低级烷基、环烷基低级烷基、##STR2## Ar低级烷基的式子##STR3##其中Z是氢、低级烷基、低级烷氧基、卤素CF.sub.3、NO.sub.2和NH.sub.2；芳氧基低级烷基的式子##STR4##其中Z如前所述；以及式子##STR5##中的烷基胺，其中R.sub.1和R.sub.2相同或不同，是氢和低级烷基，n是1或2的整数；以及其药学上可接受的酸盐。
• 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04988690A1

  公开（公告）日：1991-01-29

  The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same or different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF.sub.3, NO.sub.2, CN and NH.sub.2 ; R is hydrogen, lower alkyl, cycloalkyllower alkyl, ##STR2## Ar lower alkyl of the formula -alkylene ##STR3## where Z is hydrogen, lower alkyl, lower alkoxy, halogen, CF.sub.3, NO.sub.2 and NH.sub.2 ; and an alkylene amine of the formula ##STR4## where R.sub.1 and R.sub.2 are the same of different and are hydrogen and lower alkyl, and the pharmaceutically acceptable acid addition salts thereof.

  本发明涉及式为##STR1##的1-芳氧基-2,3,4,5-四氢-3-苯并哌啶，其中Y相同或不同，为氢和较低的烷氧基；X为氢、卤素、较低的烷基、较低的烷氧基、CF.sub.3、NO.sub.2、CN和NH.sub.2；R为氢、较低的烷基、环烷基较低的烷基、##STR2##Ar为-烷基-##STR3##的较低烷基，其中Z为氢、较低的烷基、较低的烷氧基、卤素、CF.sub.3、NO.sub.2和NH.sub.2；以及式为##STR4##的烷基胺和其药学上可接受的酸盐。
• 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05059688A1

  公开（公告）日：1991-10-22

  The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same or different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF.sub.3, No.sub.2, CN and NH.sub.2 ; R is hydrogen, lower alkyl, cycloalkyllower alkyl, ##STR2## Ar lower alkyl of the formula ##STR3## where Z is hydrogen, lower alkyl, lower alkoxy, halogen CF.sub.3, NO.sub.2 and NH.sub.2 ; Aryloxy lower alkyl of the formula ##STR4## where Z is as previously defined; and an alkylene amine of the formula ##STR5## where R.sub.1 and R.sub.2 are the same or different and are hydrogen and lower alkyl, n is an integer of 1 or 2; and the pharmaceutically acceptable acid addition salts thereof.

  本发明涉及公式## STR1的1-芳氧基-2,3,4,5-四氢-3-苯并氮平，其中Y相同或不同，为氢和低级烷氧基; X为氢，卤素，低级烷基，低级烷氧基，CF.sub.3，No.sub.2，CN和NH.sub.2; R为氢，低级烷基，环烷基低级烷基，## STR2的公式，Ar为## STR3的公式的芳基低级烷基，其中Z为氢，低级烷基，低级烷氧基，卤素CF.sub.3，NO.sub.2和NH.sub.2;芳氧基低级烷基的公式## STR4，其中Z如前所述;以及公式## STR5的烷基胺，其中R.sub.1和R.sub.2相同或不同，为氢和低级烷基，n为1或2;和其药学上可接受的酸加盐。
• 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0096838A1

  公开（公告）日：1983-12-28

  The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3- benzazepines of the formula wherein Y, and Y2 are the same or different and are hydrogen or lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF3, NO2, CN and NH2; R is hydrogen, lower alkyl, cycloatkyllower alkyl Ar lower alkyl of the formula -alkylene where Z is hydrogen, lower alkyl, lower alkoxy, halogen, CF3, NO2; and NH2; and an alkylene amine of the formula -alkylene where R, and R2 are the same or different and are hydrogen and lower alkyl and the alkylene moiety is of 1 to 6 carbon atoms, and the pharmaceutically acceptable acid addition salts thereof.

  本发明涉及 1-芳氧基-2,3,4,5-四氢-3-苯并氮杂卓，其式为 其中 Y 和 Y2 是相同或不同的，并且是氢或低级烷氧基；X 是氢、卤素、低级烷基、低级烷氧基、CF3、NO2、CN 和 NH2；R 是氢、低级烷基、环烷基低级烷基 Ar 式中的低级烷基-亚烷基 其中 Z 是氢、低级烷基、低级烷氧基、卤素、CF3、NO2 和 NH2；以及式 - 烷基胺 其中 R 和 R2 相同或不同，且为氢和低级烷基，亚烷基为 1 至 6 个碳原子，以及它们的药学上可接受的酸加成盐。
• US4794181A
  申请人：——

  公开号：US4794181A

  公开（公告）日：1988-12-27