2-(methylselanyl)-5-(trifluoromethyl)benzaldehyde | 1350431-41-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(methylselanyl)-5-(trifluoromethyl)benzaldehyde
• 英文别名: 2-(Methylseleno)-5-(trifluoromethyl)benzaldehyde；2-methylselanyl-5-(trifluoromethyl)benzaldehyde
• CAS: 1350431-41-2
• 化学式: C₉H₇F₃OSe
• 分子量: 267.109
• InChiKey: GBOXLBVMTYTTKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二甲基二硒醚 、 2-氯-5-三氟甲基苯甲醛 在 DL-dithiothreitol 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以75%的产率得到2-(methylselanyl)-5-(trifluoromethyl)benzaldehyde
  参考文献：
  名称：

  셀레닐-치환된 방향족 알데하이드계 화합물의 신규 제조 방법

  摘要：

  本发明涉及一种新的制备含硒芳基醛类化合物的方法，具体地，涉及一种制备含硒芳基醛类化合物的新方法，包括形成硒醇酯亲核体，通过亲核性取代芳基醛类起始物质进行硒取代的步骤。

  公开号：

  KR101493032B1

文献信息

• NOVEL METHOD FOR PREPARING SELENYL-SUBSTITUTED AROMATIC ALDEHYDE COMPOUNDS
  申请人：Lim Dongyeol

  公开号：US20140012021A1

  公开（公告）日：2014-01-09

  The present disclosure relates to a novel method for preparing selenyl-substituted aromatic aldehyde compounds by forming a selenolate nucleophile and performing a nucleophilic substitution reaction between the selenolate nucleophile and an aromatic aldehyde starting material.

  本公开涉及一种新的制备硒代芳香醛化合物的方法，通过形成硒醇根亲核试剂，并在硒醇根亲核试剂和芳香醛起始物之间进行亲核取代反应。
• 셀레닐-치환된 방향족 알데하이드계 화합물의 신규 제조 방법
  申请人：INDUSTRY ACADEMY COOPERATION FOUNDATION OF SEJONG UNIVERSITY 세종대학교산학협력단(220050114702) BRN ▼206-82-07591

  公开号：KR101493032B1

  公开（公告）日：2015-02-17

  본원은, 셀레닐-치환된 방향족 알데하이드(selenyl-substituted aromatic aldehyde)계 화합물의 신규한 제조 방법에 관한 것으로서, 구체적으로, 셀레놀레이트 친핵체(selenolate nucleophile)를 형성하여 방향족 알데하이드계 출발물질을 친핵성 치환시키는 것을 포함하는, 셀레닐-치환된 방향족 알데하이드계 화합물의 신규한 제조 방법에 관한 것이다.

  本发明涉及一种新的制备含硒芳基醛类化合物的方法，具体地，涉及一种制备含硒芳基醛类化合物的新方法，包括形成硒醇酯亲核体，通过亲核性取代芳基醛类起始物质进行硒取代的步骤。
• Mild generation of selenolate nucleophiles by thiol reduction of diselenides: convenient syntheses of selenyl-substituted aryl aldehydes
  作者：Rashmi Dubey、Hangeun Lee、Do-Hyun Nam、Dongyeol Lim

  DOI：10.1016/j.tetlet.2011.10.075

  日期：2011.12

  Various selenyl-substituted aryl aldehydes were obtained using dithiothreitol (DTT) as a reducing agent for diselenides in the presence of a base. For electron-deficient haloaryl aldehydes, a weak base, such as K2CO3, performed well. However, for electron-rich haloaryl aldehydes, a stronger base, such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), was required for successful substitution. The selenyl-substitution of heteroaryl substrates were also investigated to obtain satisfactory yields of the desired products. (C) 2011 Elsevier Ltd. All rights reserved.