1-Dimethylamino-pyrrolidin-2-one | 101306-01-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Dimethylamino-pyrrolidin-2-one
• 英文别名: 1-(Dimethylamino)pyrrolidin-2-one
• CAS: 101306-01-8
• 化学式: C₆H₁₂N₂O
• 分子量: 128.174
• InChiKey: CKGBGEDXYODRBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-chloro-N',N'-dimethylbutanehydrazide 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以80%的产率得到1-Dimethylamino-pyrrolidin-2-one
  参考文献：
  名称：

  A Simple and Efficient Synthesis of LactoneN,N-Dialkylhydrazones and their IsomericN-(Dialkylamino)-lactams

  摘要：

  迄今未知的乳酮N,N-二烷基酰肼 2 和 N-(二烷基氨基)内酰胺 3 已通过一个简单的两步程序合成，产率良好，该程序涉及银四氟硼酸盐或氢化钠催化的环化反应，原料为ω-氯代烷酰肼 1，而后者可便捷地由ω-氯代烷酰氯与酰肼反应制得。

  DOI：

  10.1055/s-1985-31213

文献信息

• [EN] CDK INHIBITORS<br/>[FR] INHIBITEURS DE CDK
  申请人：QILU REGOR THERAPEUTICS INC

  公开号：WO2020224568A1

  公开（公告）日：2020-11-12

  Provided is a compound represented by structural formula (I), or a pharmaceutically acceptable salt, or a stereoisomer thereof useful for treating cancer.

  提供的是一种由结构式（I）表示的化合物，或者其药用盐，或者其立体异构体，用于治疗癌症。
• Selective preventives/remedies for progressive lesions after organ damage
  申请人：——

  公开号：US20030181506A1

  公开（公告）日：2003-09-25

  An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.

  本发明的目的是提供一种药物制剂，用于在有机损伤后预防和/或治疗渐进性病变，而不抑制有机功能或再生功能，通过选择性抑制细胞毒性效应巨噬细胞的诱导，这些巨噬细胞是在损伤的器官中受化学因子和细胞因子诱导而表达的，这些化学因子和细胞因子取决于损伤的有机组织的类型。
• Method for covalently attaching nucleosides and/or nucleotides on surfaces and method for determining coupling yields in the synthesis of nucleotides
  申请人：Stengele Klaus-Peter

  公开号：US20060154256A1

  公开（公告）日：2006-07-13

  The present invention relates to a method for covalently attaching nucleosides and/or nucleotides on surfaces having reactive functional groups, where in a first step, the reactive functional groups are made to react with suitable derivatized nucleosides and/or nucleotides, and in a second step, they are converted with a protecting group reagent, so that a reaction product of the consecutive reaction interacts with electromagnetic radiation such that it can be quantitatively determined. The invention also relates to a method for determining the repetitive coupling yields in the synthesis of nucleotides where the free 3′ or 5′ hydroxy group of a selected nucleoside and/or nucleotide is converted with a compound of formula (I) where L is a common suitable leaving group, the motif O—PX represents a phosphor amidite, a H-phosphonate a phosphonic acid ester, a phosphotriester, Y═O or S, N is a nucleoside or a nucleotide derivative which subsequently reacts further with a protecting group reagent and the elimination of the leaving group (L), which is subsequently further eliminated. The quantity of the leaving group (L) eliminated in step b) is quantitatively determined in the form of its anion (L − ) by means of optical spectroscopy.

  本发明涉及一种在具有反应性功能团的表面上共价连接核苷和/或核苷酸的方法。其中，在第一步中，反应性功能团与适当衍生的核苷和/或核苷酸发生反应，在第二步中，它们与保护基试剂转化，使得连续反应的反应产物与电磁辐射相互作用，从而可以定量测定。该发明还涉及一种确定核苷酸合成中重复偶联收率的方法，其中选择的核苷和/或核苷酸的自由3'或5'羟基转化为化合物(I)的形式，其中L是一种常见的适当离去基，O-PX基序列代表磷酰胺、H-膦酸酯、磷酸酯、磷酸三酯，Y=O或S，N是一个核苷或核苷酸衍生物，随后进一步与保护基试剂反应，并消除离去基(L)，随后进一步消除。步骤b)中消除的离去基(L)的数量以其阴离子(L-)的形式通过光谱学定量测定。
• Bleed resistance of dyes by counter-ion substitution
  申请人：Hewlett-Packard Company

  公开号：EP0645438A2

  公开（公告）日：1995-03-29

  Color bleed on paper media printed by ink-jet is alleviated by altering the dyes such that they become more bleed resistant. To this end, an organic compound with surfactant properties is substituted as the dye counter-ion. Specifically, a dye having one or more sulfonate or carboxylate groups is provided with a counter-ion comprising an amine having the formula given by         ⁺N-(CH₃)mH3-m-(CH₂)n-R where m ranges from 1 to 3, n ranges from 3 to 6, and R a hydrophilic substituent or cycloaliphatic or aromatic group with a hydrophilic substituent. An ink employing the dye of the invention comprises (a) about 0.5 to 40 wt% of one or more low vapor pressure solvents (b) about 0.5 to 5 wt% one or more water-soluble dyes in which one or more of the counter-ions have been substituted with the above amine, and (c) the balance water.

  通过改变染料使其具有更强的抗渗性，可以减轻喷墨打印纸张介质上的渗色现象。为此，一种具有表面活性剂特性的有机化合物被替代为染料的反离子。具体地说，具有一个或多个磺酸盐或羧酸盐基团的染料被提供一个反离子，该反离子由具有如下式子的胺组成 ⁺N-(CH₃)mH3-m-(CH₂)n-R 其中 m 为 1 至 3，n 为 3 至 6，R 为亲水取代基或带有亲水取代基的环脂族或芳香族基团。采用本发明染料的墨水包括：(a) 约 0.5 至 40 wt%的一种或多种低蒸汽压溶剂；(b) 约 0.5 至 5 wt%的一种或多种水溶性染料，其中一种或多种反离子已被上述胺取代；(c) 余量为水。
• SELECTIVE PREVENTIVES/REMEDIES FOR PROGRESSIVE LESIONS AFTER ORGAN DAMAGE
  申请人：Ishibashi, Michio

  公开号：EP1277747A1

  公开（公告）日：2003-01-22

  An object of the present invention is to provide a pharmaceutical agents for preventing and/or treating the progressive lesion after the organic damage without inhibiting organic function or regeneration function thereof, by selectively suppressing the induction of cytotoxic effector macrophages which are induced into the damaged organs in response to chemokines and cytokines which are expressed depending on the type of damaged organic tissues.

  本发明的目的是提供一种药剂，通过选择性地抑制细胞毒性效应巨噬细胞的诱导，预防和/或治疗机体损伤后的进行性病变，而不抑制机体功能或其再生功能。