Methyl (2S)-1-(N-cyclohexylcarbamoyl)pyrrolidine-2-carboxylate | 222171-38-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl (2S)-1-(N-cyclohexylcarbamoyl)pyrrolidine-2-carboxylate
• 英文别名: methyl (2S)-1-(cyclohexylcarbamoyl)pyrrolidine-2-carboxylate
• CAS: 222171-38-2
• 化学式: C₁₃H₂₂N₂O₃
• 分子量: 254.329
• InChiKey: WNRXPIQTUVDIBT-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl (2S)-1-(N-cyclohexylcarbamoyl)pyrrolidine-2-carboxylate 在 LiOH 作用下， 以 甲醇 为溶剂， 生成 (2S)-1-(cyclohexyl)carbamoyl-2-pyrrolidinecarboxylic acid
  参考文献：
  名称：

  Ureas of N-heterocyclic carboxylic acids and carboxylic acid isosteres

  摘要：

  本发明涉及新型N-杂环羧酸和羧酸异构体的脲或碳酸酯，它们的制备以及用于治疗包括受到物理损伤的神经和神经退行性疾病以及治疗脱发和促进头发生长的神经系统疾病的使用。

  公开号：

  US20020007075A1

文献信息

• Ureas of N-heterocyclic carboxylic acids and carboxylic acid isosteres
  申请人：——

  公开号：US20020007075A1

  公开（公告）日：2002-01-17

  This invention relates to novel ureas or carbamates of N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.

  本发明涉及N-杂环羧酸和羧酸异构体的新型脲或氨基甲酸酯，其制备和用于治疗神经系统疾病，包括身体受损的神经和神经退行性疾病，以及治疗脱发和促进头发生长。
• Ureas and carbamates of N-Heterocyclic carboxylic acids and carboxylic acid isosteres
  申请人：Guilford Pharmaceuticals

  公开号：US20020042442A1

  公开（公告）日：2002-04-11

  This invention relates to novel ureas or carbamates of N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.

  本发明涉及N-杂环羧酸和羧酸异构体的新型脲或氨基甲酸酯，其制备和用于治疗神经系统疾病，包括受损神经和神经退行性疾病，以及治疗脱发和促进头发生长。
• Method for preventing and treating hearing loss using sensorineurotrophic compounds
  申请人：Amgen Inc.

  公开号：US20040186098A1

  公开（公告）日：2004-09-23

  The present invention relates generally to methods for preventing and/or treating injury or degeneration of cochlear hair cells and spiral ganglion neurons by administering sensorineurotrophic compounds described below. The invention relates more specifically to methods for treating sensorineural hearing loss as well as vestibular disorders and tinnitus.

  本发明通常涉及通过给予下文所述的感觉神经营养化合物来预防和/或治疗耳蜗毛细胞和螺旋神经节神经元的损伤或退化的方法。该发明更具体地涉及治疗感觉神经性听力损失以及前庭障碍和耳鸣的方法。
• Method for treating nerve injury caused as a result of surgery
  申请人：——

  公开号：US20030203890A1

  公开（公告）日：2003-10-30

  The present invention relates generally to methods for treating or preventing nerve injury in a warm-blooded animal caused as a consequence of surgery by administering neurotrophic compounds described below. The invention relates more specifically to methods for treating or preventing nerve injury caused as a consequence of prostate surgery as well as erectile dysfunction.

  本发明一般涉及通过给予下文描述的神经营养化合物来治疗或预防温血动物因手术而引起的神经损伤的方法。该发明更具体地涉及治疗或预防由前列腺手术以及勃起功能障碍引起的神经损伤的方法。