2-ethoxy-5-methylphenol | 2563-04-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-ethoxy-5-methylphenol
• 英文别名: 2-ethoxy-5-methyl-phenol；2-Aethoxy-5-methyl-phenol；3-Oxy-4-aethoxy-1-methyl-benzol；1-Ethoxy-2-hydroxy-4-methyl-benzol
• CAS: 2563-04-4
• 化学式: C₉H₁₂O₂
• 分子量: 152.193
• InChiKey: VYFBJTVUYMABTA-UHFFFAOYSA-N

物化性质

• 熔点：
  58 °C
• 沸点：
  100-125 °C(Press: 12 Torr)
• 密度：
  1.052±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethoxy-5-methylphenol 在 sodium hydroxide 、 氯仿 作用下， 生成 5-ethoxy-4-hydroxy-2-methyl-benzaldehyde
  参考文献：
  名称：

  DE91170

  摘要：

  公开号：
• 作为产物：
  描述：

  2-氨基-4-甲基苯乙醚 在 硫酸 作用下， 生成 2-ethoxy-5-methylphenol
  参考文献：
  名称：

  DE103146

  摘要：

  公开号：

文献信息

• NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVING BOTH AROMATIC AND HALOGENIC SUBSTITUENTS
  申请人：Lori Franco

  公开号：US20140057911A1

  公开（公告）日：2014-02-27

  Certain 4,6-disubstituted aminopyrimidine derivatives having both aromatic and halogenic substituents.

  某些具有芳香族和卤素取代基的4,6-二取代氨基嘧啶衍生物。
• Facile and Regioselective Dealkylation of Alkyl Aryl Ethers Using Niobium(V) Pentachloride
  作者：Yukinori Sudo、Shigeru Arai、Atsushi Nishida

  DOI：10.1002/ejoc.200500502

  日期：2006.2

  A simple and facile method for the cleavage of carbon–oxygen bonds promoted by niobium pentachloride(V) is described. Excellent yields and regioselectivities were observed with various alkyl aryl ethers to give the phenols. NMR studies revealed the formation of monoaryloxy niobium salt(V), and a neighboring-group effect may play a significant role in the regioselectivity. (© Wiley-VCH Verlag GmbH &

  描述了一种由五氯化铌 (V) 促进的碳-氧键断裂的简单易行的方法。用各种烷基芳基醚得到酚类时观察到优异的产率和区域选择性。核磁共振研究揭示了单芳氧基铌盐 (V) 的形成，相邻基团效应可能在区域选择性中起重要作用。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSES ORGANIQUES
  申请人：SPEEDEL EXPERIMENTA AG

  公开号：WO2005061457A1

  公开（公告）日：2005-07-07

  Novel substituted piperidines of the general formulae (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.

  描述了一种具有一般式(I)和(II)的新型替代哌啶化合物，其中详细说明了取代基定义。这些化合物特别适用作为肾素抑制剂，并且具有很高的效力。
• Functionalized Photoreactive Compounds
  申请人：Cherkaoui Mohammed Zoubair

  公开号：US20080274304A1

  公开（公告）日：2008-11-06

  The present invention concerns functionalized photoreactive compounds of formula (I), that are particularly useful in materials for the alignment of liquid crystals. Due to the adjunction of an electron withdrawing group to specific molecular systems bearing an unsaturation directly attached to two unsaturated ring systems, exceptionally high photosensitivities, excellent alignment properties as well as good mechanical robustness could be achieved in materials comprising said functionalized photoreactive compounds of the invention.

  本发明涉及式(I)的官能化光反应化合物，特别适用于液晶对准材料。由于在特定分子系统中的不饱和键直接连接到两个不饱和环系统上附加了一个电子受体基团，因此在包含本发明的这些官能化光反应化合物的材料中可以实现异常高的光敏性、优异的对准性能以及良好的机械稳健性。
• A Simple and Regioselective Carbon-Oxygen Bond Cleavage Using Niobium(V)
  作者：Shigeru Arai、Atsushi Nishida、Yukinori Sudo

  DOI：10.1055/s-2004-817766

  日期：——

  A simple and convenient method for the differentiation of alkoxy groups on aromatic rings is described. Niobium(V) is found to possess a strong Lewis acid property to transform alkyl arylethers smoothly to the corresponding phenols in high yields. The excellent regioselectivity was also observed in dialkoxy ­benzene derivatives under mild conditions.

  描述了一种简单便捷的方法，用于区分芳香环上的烷氧基团。发现五氧化铌具有强的路易斯酸性，可以将烷基芳基醚顺利转化为相应的酚类，且产率较高。在温和条件下，还观察到了二烷氧基苯衍生物的优良区位选择性。