2,6-Dichlor-benzoldiazonium | 45739-20-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-Dichlor-benzoldiazonium
• 英文别名: 2,6-Dichlorobenzenediazonium
• CAS: 45739-20-6
• 化学式: C₆H₃Cl₂N₂
• 分子量: 174.009
• InChiKey: JRENUPXCBFCKDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-Dichlor-benzoldiazonium 在 sodium hydroxide 、 copper diacetate 、 甲苯 作用下， 生成 1-(2,6-Dibutoxy-phenylazo)-[2]naphthol
  参考文献：
  名称：

  Stepanow; Andreewa, Chemija, 1959, p. 141

  摘要：

  DOI：
• 作为产物：
  描述：

  盐酸 、 2,6-二硝基苯胺 、 溶剂黄146 生成 2,6-Dichlor-benzoldiazonium 、 2,6-二硝基氯苯
  参考文献：
  名称：

  Sihlbom, Acta Chemica Scandinavica (1947), 1953, vol. 7, p. 1197,1198,1199,1204

  摘要：

  DOI：

文献信息

• Predominance of 2-arylhydrazones of 1,3-diphenylpropane-1,2,3-trione over its proton-transfer products
  作者：Ryszard Gawinecki、Erkki Kolehmainen、Henryk Janota、Reijo Kauppinen、Maija Nissinen、Borys O?mia?owski

  DOI：10.1002/poc.435

  日期：2001.11

  substituent effect is transmitted effectively only to the hydrazone nitrogen and hydrogen atoms. Ab initio calculations show that the ketohydrazone tautomer is really very much favoured over its proton-transfer products in chloroform solution. The same tautomer was also detected in the crystal state by X-ray crystallography. Copyright © 2001 John Wiley & Sons, Ltd.

  通过15 N NMR化学位移在氯仿溶液中检测到1,3-二苯基-1,2,3-三酮的2-苯hydr是主要的互变异构形式。苯hydr部分中的取代基不影响该互变异构偏好。取代基效应仅有效地传递至的氮和氢原子。从头算计算表明，酮hydr互变异构体确实比氯仿溶液中的质子转移产物更受青睐。还通过X射线晶体学在晶体状态下检测到相同的互变异构体。版权所有©2001 John Wiley＆Sons，Ltd.
• α-Nitrohydrazones: versatile intermediates for phosphonate derivatives formation from primary nitro compounds
  作者：L El Kaı̈m、L Grimaud、N.K Jana、C Tirla

  DOI：10.1016/s0040-4039(02)00208-3

  日期：2002.3

  Primary nitro compounds can be easily converted into hydrazonophosphonate derivatives through coupling with aryldiazonium salts followed by an Arbuzov-type reaction with phosphite.

  通过与芳基重氮盐偶合，然后与亚磷酸酯进行Arbuzov型反应，伯硝基化合物很容易转化为肼代膦酸酯衍生物。
• Method and apparatus for determination of an analyte and method of calibrating such apparatus
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0158506A2

  公开（公告）日：1985-10-16

  A method and apparatus are described for the determination of an analyte in an aqueous liquid which eliminate the biasing effect of unknown interferents which are either preformed or formed in situ during the determination. The method comprises physically contacting a sample of the liquid with an interactive composition for the analyte, measuring the spectrophotometric responses generated by such contact at a primary wavelength λ1 and one or more secondary wavelengths λ2, λ3, ...λn, and determining analyte concentration or activity using the equation: wherein C is analyte concentration or activity, A,, A2, ...An are the spectrophotometric responses observed at λ1, λ2, ...λn, respectively, and ao, a,, and α1, a2, ...αn-1 are constants determined according to a calibrating method. Such calibrating method is an empirical means for determining and recording in a chemical analyzer the a0,a1, and α1,α2, ...an-i constants essential for making the analyte determination.

  本发明描述了一种测定水性液体中分析物的方法和装置，它消除了在测定过程中预先形成或就地形成的未知干扰物的偏差效应。该方法包括将液体样品与分析物的交互组合物进行物理接触，在一个主波长 λ1 和一个或多个次波长 λ2、λ3、...λn 上测量由这种接触产生的分光光度反应，并使用公式确定分析物浓度或活性： 其中 C 是分析物浓度或活性，A,, A2, ...An分别是在λ1, λ2, ...λn处观察到的分光光度反应，ao, a, 和 α1, a2, ...αn-1是根据校准方法确定的常数。这种校准方法是一种经验方法，用于确定和记录化学分析仪中的 a0、a1 和 α1、α2、......an-i 常量，这些常量对确定被分析物至关重要。
• Gram negative bacteruria test
  申请人：MILES INC.

  公开号：EP0224830A2

  公开（公告）日：1987-06-10

  A screening method for the determination of 10⁴ gram negative bacteria per milliliter of an undiluted urine sample and a unitary screening test device for the determination of at least 10⁵ gram negative bacteria per milliliter of an undiluted urine sample. The method and test device make use of Limulus amebocyte lysate (LAL) and a synthetic substrate containing a chromogenic or fluorogenic leaving group capable of being cleaved by activated lysate. This screening method and unitary screening device provide a quick, convenient, inexpensive indication of the possible presence of a urinary tract infection caused by gram negative bacteria.

  一种用于测定每毫升未稀释尿液样本中 10 ⁴ 个革兰氏阴性细菌的筛查方法，以及一种用于测定每毫升未稀释尿液样本中至少 10 ⁵ 个革兰氏阴性细菌的单元筛查测试装置。该方法和检测装置使用了嗜酸性粒细胞裂解液（LAL）和一种合成底物，该底物含有可被活化裂解液裂解的发色或发荧光的离去基团。这种筛查方法和单一的筛查装置可快速、方便、廉价地显示是否存在由革兰氏阴性细菌引起的尿路感染。
• Method for detecting a target polynucleotide in a sample using a background reducing reagent and composition and kit comprising such a reagent
  申请人：ENZO DIAGNOSTICS, INC.

  公开号：EP0492570A1

  公开（公告）日：1992-07-01

  The present invention provides a method for detecting the presence of a target polynucleotide in a sample. The method comprises the steps of (a) contacting the sample under hybridizing conditions with (i) a single-stranded polynucleotide probe capable of hybridizing to the target polynucleotide and comprising a polynucleotide and at least one intercalating molecule attached to a nucleotide of the polynucleotide by means of a linker arm, and (ii) a background-reducing reagent which chemically modifies the intercalating molecule when the probe to which it is attached is single-stranded; and (b) detecting a property change resulting from the intercalation of the intercalating molecule into a target-probe hybrid, thereby detecting the target polynucleotide. The intercalating molecule which is part of the polynucleotide probe induces a change in a property, in either the probe, the target polynucleotide or a target-probe hybrid. The property change can be detected, for example, by means of a generated signal which can be identified or quantified. The present invention can be employed in a heterogeneous (two step or two phase) assay using a support to immobilize the target or probe, and a washing step, and in a homogeneous (one step or one phase) assay using a hybridization solution. Also provided are a composition and a nucleic acid hybridization kit useful for detecting the presence of a target polynucleotide in a sample.

  本发明提供了一种检测样品中是否存在目标多核苷酸的方法。该方法包括以下步骤：(a) 在杂交条件下将样品与(i) 能与目标多核苷酸杂交的单链多核苷酸探针接触，该探针包括多核苷酸和至少一个通过连接臂连接到多核苷酸核苷酸上的插层分子；(ii) 背景还原试剂，当插层分子所连接的探针是单链时，该试剂会对插层分子进行化学修饰；(b) 检测插层分子插层到目标-探针杂交体后产生的性质变化，从而检测目标多核苷酸。作为多核苷酸探针一部分的插层分子会引起探针、目标多核苷酸或目标-探针杂交体的性质变化。例如，可以通过产生的可识别或量化的信号来检测性质的变化。本发明可用于异质（两步或两相）检测，使用支持物固定靶标或探针，并进行洗涤步骤；也可用于均质（一步或一相）检测，使用杂交溶液。此外，还提供了一种用于检测样品中是否存在目标多核苷酸的组合物和核酸杂交试剂盒。