[(E)-prop-1-enyl] propanoate | 33603-00-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(E)-prop-1-enyl] propanoate
• CAS: 33603-00-8
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: AOJIRGQJECGWRU-HWKANZROSA-N

物化性质

• 沸点：
  123.6±9.0 °C(Predicted)
• 密度：
  0.915±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-chloro-3-phenyl-3H-diazirine 、 [(E)-prop-1-enyl] propanoate 生成 (2-chloro-3-methyl-2-phenylcyclopropyl) propanoate
  参考文献：
  名称：

  DOYLE, M. P.;TERPSTRA, J. W.;WINTER, CH. H., TETRAHEDRON LETT., 1984, 25, N 9, 901-904

  摘要：

  DOI：
• 作为产物：
  描述：

  丙醛 、 丙酸酐 在 potassium propylate 作用下， 生成 [(E)-prop-1-enyl] propanoate
  参考文献：
  名称：

  Palladium (II)-Catalyzed Exchange and Isomerization Reactions. VII. Isomerization and Exchange of Enol Propionates in Acetic Acid Catalyzed by Palladium (II) Chloride

  摘要：

  DOI：

  10.1021/ja00776a602

文献信息

• [EN] CARBOSTYRIL COMPOUND<br/>[FR] DÉRIVÉ DE CARBOSTYRILE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2006035954A1

  公开（公告）日：2006-04-06

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的羧基吲哚化合物或其盐，其中A是直链键、较低的烷基烯基或较低的烷基亚烯基；X是氧原子或硫原子；R4和R5分别表示氢原子；羧基吲哚骨架的3和4位置之间的键是单键或双键；R1是氢原子，等等；R2是氢原子，等等；R3是氢原子，等等。本发明的羧基吲哚化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和伤口等疾病。
• Carbostyril compound
  申请人：Kuroda Takeshi

  公开号：US20070179173A1

  公开（公告）日：2007-08-02

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R 4 and R 5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R 1 is a hydrogen atom, etc; R 2 is a hydrogen atom, etc; and R 3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的碳基噻吩化合物或其盐，其中A是直接键，较低的烷基烷基或较低的烷基亚烷基；X是氧原子或硫原子；R4和R5分别表示氢原子；碳基噻吩骨架的3和4位之间的键是单键或双键；R1是氢原子等；R2是氢原子等；R3是氢原子等。本发明的碳基噻吩化合物或其盐能够诱导TFF的产生，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和伤口等疾病。
• Method for Producing Mono-Carboxy-Functionalized Dialkylphosphinic Acids, Esters and Salts Using a Vinyl Ester of a Carboxylic Acid and the Use Thereof
  申请人：Hill Michael

  公开号：US20110237721A1

  公开（公告）日：2011-09-29

  The invention relates to a method for producing mono-carboxy-functionalized dialkyiphosphinic acids, esters and salts using a vinyl ester of a carboxylic acid. The method is characterized by the following steps: a) reacting a phosphinic acid source (I) with olefins (IV) in the presence of a catalyst A to give an alkylphosphinic acid, the salt or the ester (II) thereof, b) reacting the alkylphosphinic acid so obtained, the salt or the ester (II) thereof with a vinyl ester of a carboxylic acid of formula (V) in the presence of a catalyst B to give a mono-functionalized dialkylphosphinic acid derivative (VI) and c) reacting the mono-functionalized dialkyiphosphinic acid derivative (VI) so obtained in the presence of a catalyst C to give a mono-functionalized dialkylphosphinic acid derivative (VII) and d) reacting the mono-functionalized dialkyiphosphinic acid derivative (VII); with an oxidant or in the presence of a catalyst D to give a mono-carboxy-functionalized dialkylphosphinic acid derivative (III), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 are the same or different and independently of each other inter alia represent H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl and X and Y are the same or different and independently of each other represent H, C 1 -C 18 alkyl, C 8 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base and the catalysts A and D are transition metals and/or transition metal compounds and/or catalyst systems which are composed of a transition metal and/or a transition metal compound and at least one ligand, and the catalyst B is a peroxide-forming compound and/or a peroxo compound and/or an azo compound, and the catalyst C is an acid or a base.

  本发明涉及一种使用羧酸乙烯酯制备单羧基功能化二烷基膦酸、酯和盐的方法。该方法的特点在于以下步骤：a）在催化剂A的存在下，将膦酸源（I）与烯烃（IV）反应，得到烷基膦酸、其盐或酯（II），b）在催化剂B的存在下，将所得的烷基膦酸、其盐或酯（II）与式（V）的羧酸乙烯酯反应，得到单功能化的二烷基膦酸衍生物（VI），c）在催化剂C的存在下，将所得的单功能化的二烷基膦酸衍生物（VI）反应，得到单功能化的二烷基膦酸衍生物（VII），d）在氧化剂的存在下或在催化剂D的存在下，将所得的单功能化的二烷基膦酸衍生物（VII）反应，得到单羧基功能化的二烷基膦酸衍生物（III），其中R1、R2、R3、R4、R5、R6相同或不同，独立地表示H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基，X和Y相同或不同，独立地表示H、C1-C18烷基、C8-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基、Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K和/或质子化氮碱，催化剂A和D是过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物和至少一种配体组成的催化剂体系，催化剂B是过氧化物形成化合物和/或过氧化物和/或偶氮化合物，催化剂C是酸或碱。
• CARBOSTYRIL COMPOUND
  申请人：Kuroda Takeshi

  公开号：US20100261705A1

  公开（公告）日：2010-10-14

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R 4 and R 5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R 1 is a hydrogen atom, etc; R 2 is a hydrogen atom, etc; and R 3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的羧基苯基咔唑化合物或其盐，其中A表示直接键，较低的烷基烷基或较低的烷基亚甲基烷基；X表示氧原子或硫原子；R4和R5各代表氢原子；羧基苯基咔唑骨架的3和4位置之间的键是单键或双键；R1是氢原子等；R2是氢原子等；R3是氢原子等。本发明的羧基苯基咔唑化合物或其盐可诱导TFF的产生，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和创伤等疾病。
• Method for the Production of Monofunctionalized Dialkylphosphinic Acids, Esters and Salts, and Use Thereof
  申请人：Hill Michael

  公开号：US20110251315A1

  公开（公告）日：2011-10-13

  The invention relates to a method for producing monofunctionalized dialkylphosphinic acids, esters, and salts, characterized in that a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to obtain an alkylphosphonous acid, the salt or ester thereof, whereupon said alkylphosphonous acid, the salt or ester (II) thereof is reacted with compounds containing C═C, C═O, or C═N double bonds to obtain compounds of type (III), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 are identical or different from each other and independently represent, inter alia, H, C 1 -C 18 -alkyl, C 6 -C 18 -aryl, C 6 -C 18 -aralkyl, X represents, inter alia, H, C 1 -C 18 -alkyl, C 6 -C 18 -aryl, and/or Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K, H, and wherein A represents OH, NH 2 , NHR, NR 2 , or O—CO—R 8 , and W represents a mineral acid, carboxylic acid, Lewis acid, or organic acid, wherein n is a whole or a fractional number from 0 to 4, and catalyst A represents transition metals and/or transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand. The use of said dialkylphosphonic acids, esters, and salts is also disclosed.

  本发明涉及一种生产单官能团二烷基膦酸、酯和盐的方法，其特征在于在催化剂A的存在下，将膦酸源（I）与烯烃（IV）反应，得到烷基膦酸、盐或酯，然后将所述烷基膦酸、盐或酯（II）与含有C═C、C═O或C═N双键的化合物反应，得到类型为（III）的化合物，其中R1、R2、R3、R4、R5、R6相同或不同，独立地代表H、C1-C18-烷基、C6-C18-芳基、C6-C18-芳基烷基，X代表H、C1-C18-烷基、C6-C18-芳基和/或Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K、H，其中A代表OH、NH2、NHR、NR2或O—CO—R8，W代表矿酸、羧酸、路易斯酸或有机酸，n是从0到4的整数或分数，催化剂A代表过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物和至少一个配体组成的催化剂体系。还公开了所述二烷基膦酸、酯和盐的用途。