3-Hydroxy-4-phenylazetidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 3-Hydroxy-4-phenylazetidin-2-one
• 化学式: C₉H₉NO₂
• 分子量: 163.17
• InChiKey: FBZSDKXFQUKDLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Hydroxy-4-phenylazetidin-2-one 、 、 氢气 、 溴化钾 在 乙酸乙酯 作用下， 以 甲醇 为溶剂， 90.0 ℃ 、735.38 MPa 条件下， 反应 120.0h， 以to give 440 mg (85%) of VIIe as a white solid的产率得到4-Cyclohexyl-3-hydroxy-2-azetidinone
  参考文献：
  名称：

  Anti-tumor compounds, pharmaceutical compositions, methods for

  摘要：

  本发明涉及作为化疗药物或其前体的新型紫杉醇。制备新型紫杉醇的过程包括在碱的存在下，将化学式（III）或（IV）的巴卡丁与化学式（V）的β-内酰胺进行偶联反应。本发明还提供包括新型紫杉醇的药物组合物以及使用这些新化合物治疗某些癌症的方法。

  公开号：

  US05599820A1

文献信息

• Beta-lactam synthesis
  申请人：Vu Phong

  公开号：US20060281914A1

  公开（公告）日：2006-12-14

  The present invention is directed to a process for the preparation of β-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the β-lactam product in a “one pot” synthesis, this process is generally performed at a higher temperature than conventional processes.

  本发明涉及一种制备β-内酰胺的方法。通常，亚胺与酮乙缩醛或烯醇酸盐进行环缩合成β-内酰胺产物，这种“一锅法”合成过程通常在比传统工艺更高的温度下进行。
• Method for cell surface display of target proteins using fadl of e.coli
  申请人：Lee Yup Sang

  公开号：US20070105150A1

  公开（公告）日：2007-05-10

  The present invention relates to an expression vector which can effectively express target proteins or peptides on the surface of cells using an outer membrane protein (FadL) of E. coli as a surface anchoring motif. Also, the present invention relates to microorganisms transformed with the expression vector, and a method for stably expressing large amounts of target proteins on the surface of cells by culturing the transformed microorganisms. Furthermore, the present invention relates to a production method of protein arrays, a production method of antibodies, and a bioconversion method, the methods being characterized by using target proteins which have been expressed on the cell surface by the inventive method. In addition, the present invention relates to a method for improving target proteins by the inventive surface expression method. The present invention allows target proteins with normal functions to be expressed on an outer cell membrane. Thus, the present invention will be useful in recombinant live vaccines, the screening of various peptides or antibodies, whole-cell adsorbents for heavy metal removal or waste water treatment, whole-cell bioconversion, and the like.

  本发明涉及一种表达载体，可利用大肠杆菌的外膜蛋白（FadL）作为表面锚定基序，有效地在细胞表面表达目标蛋白或肽。此外，本发明涉及转化了表达载体的微生物以及通过培养转化后的微生物稳定表达大量目标蛋白在细胞表面的方法。此外，本发明还涉及一种蛋白质阵列的生产方法、一种抗体的生产方法以及一种生物转化方法，这些方法的特点是使用通过本发明方法在细胞表面表达的目标蛋白。此外，本发明还涉及通过本发明表面表达方法改善目标蛋白的方法。本发明允许正常功能的目标蛋白在外细胞膜上表达。因此，本发明将在重组活疫苗、各种肽或抗体的筛选、用于重金属去除或废水处理的全细胞吸附剂、全细胞生物转化等方面有用。
• Resolution of enantiomeric mixtures of beta-lactams
  申请人：Vu Phong

  公开号：US20060281918A1

  公开（公告）日：2006-12-14

  A new process for resolution of an enantiomeric mixture of C3-hydroxyl substituted β-lactams is disclosed. Generally, the enantiomeric mixture is treated with an optically active proline acylating agent to form a C3-ester substituted β-lactam diastereomer or a mixture of C3-ester substituted β-lactam diastereomers followed by selective recovery of the unreacted enantiomer or of one of the diastereomers.

  本发明揭示了一种解决C3-羟基取代β-内酰胺对映体混合物的新工艺。通常，使用具有光学活性的脯氨酸酰化试剂处理对映体混合物，形成C3-酯取代的β-内酰胺对映异构体或C3-酯取代的β-内酰胺对映异构体混合物，然后选择性地回收未反应的对映异构体或其中一种对映异构体。
• Processes for the production of polycyclic fused ring compounds
  申请人：Vu Phong

  公开号：US20060281934A1

  公开（公告）日：2006-12-14

  The present invention provides processes for the production of polycyclic fused ring compounds. The polycyclic fused ring compounds are produced by protecting a polycyclic fused ring polyol with a bridging silicon-based protecting group and attaching a suitable side chain. Novel polycyclic fused ring compounds and intermediate compounds are also described.

  本发明提供了生产多环融合环化合物的方法。这些多环融合环化合物是通过用桥接硅基保护基保护多环融合环多醇并连接适当的侧链来生产的。还描述了新型多环融合环化合物和中间化合物。
• Processes for the preparation of docetaxel
  申请人：Vu Phong

  公开号：US20060281932A1

  公开（公告）日：2006-12-14

  The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.

  本发明提供了多西他赛的生产工艺。多西他赛的生产是通过使用基于硅的桥接保护基来保护10-DAB的C（7）和C（10）羟基。然后，得到的7,10-保护的10-DAB衍生物进行衍生化和去保护，以形成多西他赛。