2-[甲基(丙-2-烯基)氨基]乙酸 | 58788-90-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-[甲基(丙-2-烯基)氨基]乙酸
• 英文名称: N-Allylsarcosine
• 英文别名: N-(1-d2-Allyl)-N-methyl-glycin；N-Allyl-N-methyl-glycin；N-Methyl-N-prop-2-en-1-ylglycine；2-[methyl(prop-2-enyl)amino]acetic acid
• CAS: 58788-90-2
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: HSYUBISIQADVLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-烯丙基肌氨酸乙酯 在 氢氧化钾 作用下， 生成 2-[甲基(丙-2-烯基)氨基]乙酸
  参考文献：
  名称：

  Studies on anti-Fusarium disease activity of aminonitrile derivatives. III. Preventive activity of N-allylamino acids against Fusarium diseases and their mode of action.

  摘要：

  制备了32种N-烯丙基氨基酸，并测定了它们对镰刀菌病害的预防活性。N-烯丙基甘氨酸和N-烯丙基肌氨酸的酯类化合物对日本萝卜由尖孢镰刀菌萝卜专化型引起的黄变病具有强效的预防作用。这些化合物还通过叶面处理对番茄镰刀菌枯萎病有效。N-烯丙基肌氨酸盐的预防活性在酯类的醇部分的变动下变化不大。尽管正十二烷基N-烯丙基肌氨酸盐显示能有效控制镰刀菌病害，但不影响镰刀菌在琼脂培养基上的生长。预防效果依赖于施用时间。在用这些化学品处理的植物中，观察到过氧化物酶活性的增强和总酚的积累。

  DOI：

  10.1271/bbb1961.44.35

文献信息

• TETRAHYDROPYRROLOTHIAZINE COMPOUNDS
  申请人：ELI LILLY AND COMPANY

  公开号：US20130261111A1

  公开（公告）日：2013-10-03

  The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R 1 is H or F; R 2 is H, —CH 2 OH, C 1 -C 3 alkyl, R 3 is H, F, or CN; R 4 is H, F; or CN; and R 5 is H, —CH 3 , or —OCH 3 ; or a pharmaceutically acceptable salt thereof.

  本发明提供了以下式I的化合物： 其中A选自以下组合之一； R1为H或F； R2为H，—CH2OH，C1-C3烷基， R3为H，F或CN； R4为H，F；或CN；和 R5为H，—CH3，或—OCH3； 或其药学上可接受的盐。
• Suspension polymerization process
  申请人：Yoon Hichang

  公开号：US20070149652A1

  公开（公告）日：2007-06-28

  The present invention is a method of making polymeric particles having a predetermined and controlled size and size distribution. The method includes dissolving a polymer in a solvent to form a solution wherein the solvent is substantially immiscible with water. A suspension of small droplets of the solution is formed in water containing a water soluble promoter and a stabilizer comprising a surfactant free copolymer by high shear agitation. The stabilizer includes (i) about 55 to about 95 percent by weight, based on total monomer weight, of an addition polymerizable p-tert-butyl styrene and/or (ii) about 5 to about 45 percent by weight, based on total monomer weight, of an addition polymerizable ionic monomer. The solvent is removed from the droplets and the solidified polymer particles are separated from the water. The present invention as provides polymer particles having a core of polymer coated with a layer of smaller particles of a copolymer of the stabilizer described in the method.

  本发明是一种制备具有预定和可控尺寸及尺寸分布的聚合物颗粒的方法。该方法包括将聚合物溶解在溶剂中，形成一种溶液，其中该溶剂与水基本不相溶。通过高剪切搅拌，在含有水溶性促进剂和稳定剂的水中形成溶液的小液滴悬浮液。稳定剂包括（i）大约55至大约95重量％，基于总单体重量，添加可聚合的对叔丁基苯乙烯和/或（ii）大约5至大约45重量％，基于总单体重量，添加可聚合的离子单体。从液滴中去除溶剂，将固化的聚合物颗粒与水分离。本发明还提供了具有聚合物核心和包覆有所述方法中稳定剂的共聚物较小颗粒层的聚合物颗粒。
• Cosmetic composition
  申请人：AJINOMOTO CO., INC.

  公开号：US20030165448A1

  公开（公告）日：2003-09-04

  A cosmetic composition for skin and/or hair, which comprises at least one kind of substance selected from the group consisting of an N &agr; ,N G -di-acylarginine, for example, a compound represented by the following general formula (I): 1 wherein R 1 and R 2 each independently represents a straight or branched-chain alkyl group having 1 to 21 carbon atoms or a straight or branched-chain alkenyl group having 2 to 21 carbon atoms. The cosmetic composition imparts much moistness and superior conditioning effects such as body or elasticity to hair, and to skin, said composition does not impart tackiness and blocked feeling, whilst imparts superior feeling of use such as moistness.

  一种用于皮肤和/或头发的化妆品组合物，其包含以下所述组中选择的至少一种物质，即N&agr;，NG-二酰基精氨酸，例如，由下述一般式（I）表示的化合物：其中R1和R2各自独立地表示具有1至21个碳原子的直链或支链烷基或具有2至21个碳原子的直链或支链烯基。该化妆品组合物为头发提供了很多湿润和优越的调理效果，例如体积或弹性，而对于皮肤，该组合物不会产生黏腻和堵塞感，同时提供了优越的使用感，例如湿润感。
• Propylene polymer catalyst donor component
  申请人：Uhrhammer Roger

  公开号：US20080125614A1

  公开（公告）日：2008-05-29

  A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins containing magnesium, titanium, and halogen further contains an internal electron donor comprising a compound containing electron donating substituents with a structure: wherein D 1 and D 2 are selected individually from and R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 individually are hydrocarbon or substituted hydrocarbon groups containing 1 to 20 carbon atoms and R 1 , R 2 , R 3 , R 4 , R 6 , and R 7 may be hydrogen; R 4 may be —NR 2 ; and wherein groups R 1 and R 2 , R 2 and R 3 , R 3 and R 4 , R 3 and R 5 , and groups R 6 and R 7 may be joined to form a cyclic structure.

  一种固体、烃类不溶性催化剂组分，可用于聚合含有镁、钛和卤素的烯烃，进一步包含一种内部电子给体，其包含一种具有以下结构的电子给体取代基的化合物：其中D1和D2分别选自和，R、R1、R2、R3、R4、R5、R6和R7分别为含有1至20个碳原子的烃基或取代烃基，其中R1、R2、R3、R4、R6和R7可以是氢；R4可以是—NR2；以及其中R1和R2、R2和R3、R3和R4、R3和R5以及R6和R7可以连接成环状结构。
• BACE INHIBITORS
  申请人：ELI LILLY AND COMPANY

  公开号：US20150232483A1

  公开（公告）日：2015-08-20

  The present invention provides compounds of Formula I useful as BACE inhibitors in the treatment of e.g. Alzheimer's disease: wherein A is selected from the group consisting of; of; R 1 is H or F; R 2 is H, —OCH 3 , C1-C3 alkyl; R 3 is H, —CH 3 , or —OCH 3 ; and R 4 is H or F; or a pharmaceutically acceptable salt thereof.

  本发明提供了一种公式I的化合物，其在治疗例如阿尔茨海默病中作为BACE抑制剂具有用途：其中A从以下组中选择；R1为H或F；R2为H，-OCH3，C1-C3烷基；R3为H，-CH3或-OCH3；且R4为H或F；或其药学上可接受的盐。