diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate | 1376709-58-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate
• 英文别名: Diethyl 5-[(4-nitrophenoxy)carbonylamino]-3-(2-phenylethyl)thiophene-2,4-dicarboxylate
• CAS: 1376709-58-8
• 化学式: C₂₅H₂₄N₂O₈S
• 分子量: 512.54
• InChiKey: QTMSLKACXTWKLY-UHFFFAOYSA-N

物化性质

• 沸点：
  653.8±55.0 °C(Predicted)
• 密度：
  1.355±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  165
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (E)-3-(4-(tert-butyldimethylsilyloxy)phenyl)prop-2-en-1-amine 、 diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以80%的产率得到diethyl 5-[[(E)-3-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]prop-2-enyl]carbamoylamino]-3-(2-phenylethyl)thiophene-2,4-dicarboxylate
  参考文献：
  名称：

  Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents

  摘要：

  Several thieno[2,3-d]pyrimidinediones have been synthesized and examined for antibacterial activity against a range of Gram-positive and Gram-negative pathogens. Two compounds displayed potent activity (2-16 mg/L) against multi-drug resistant Gram-positive organisms, including methicillin resistant, vancomycin-intermediate, vancomycin-resistant Staphylococcus aureus (MRSA, VISA, VRSA) and vancomycin-resistant enterococci (VRE). Only one of these agents possessed moderate activity (16 -32 mg/L) against Gram-negative strains. An examination of the cytotoxicity of these agents revealed that they displayed low toxicity (40-50 mg/L) against mammalian cells and very low hemolytic activity (2-7%). Taken together, these studies suggest that thieno[2,3-d]pyrimidinediones are interesting scaffolds for the development of novel Gram-positive antibacterial agents. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.02.035
• 作为产物：
  描述：

  3-氧代-5-苯基-戊酸乙酯 在 吗啉 、 吡啶 、 1,2,3,4,5,6,7,8-八硫杂环辛烷 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 66.25h， 生成 diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate
  参考文献：
  名称：

  Thieno[2,3-d]pyrimidinedione derivatives as antibacterial agents

  摘要：

  Several thieno[2,3-d]pyrimidinediones have been synthesized and examined for antibacterial activity against a range of Gram-positive and Gram-negative pathogens. Two compounds displayed potent activity (2-16 mg/L) against multi-drug resistant Gram-positive organisms, including methicillin resistant, vancomycin-intermediate, vancomycin-resistant Staphylococcus aureus (MRSA, VISA, VRSA) and vancomycin-resistant enterococci (VRE). Only one of these agents possessed moderate activity (16 -32 mg/L) against Gram-negative strains. An examination of the cytotoxicity of these agents revealed that they displayed low toxicity (40-50 mg/L) against mammalian cells and very low hemolytic activity (2-7%). Taken together, these studies suggest that thieno[2,3-d]pyrimidinediones are interesting scaffolds for the development of novel Gram-positive antibacterial agents. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.02.035