4-Methyl-2-<4-nitrophenyl>-2-oxazolidin | 99072-30-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Methyl-2-<4-nitrophenyl>-2-oxazolidin
• 英文别名: 4-methyl-2-(4-nitrophenyl)-4,5-dihydrooxazole；4-Methyl-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole；4-methyl-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole
• CAS: 99072-30-7
• 化学式: C₁₀H₁₀N₂O₃
• 分子量: 206.201
• InChiKey: GVWMNHLTDRCGPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2-methylaziridin-1-yl)(4-nitrophenyl)methanone 在 sodium iodide 作用下， 以 丙酮 为溶剂， 生成 4-Methyl-2-<4-nitrophenyl>-2-oxazolidin
  参考文献：
  名称：

  The Isomerization and Dimerization of Aziridine Derivatives. IV

  摘要：

  DOI：

  10.1021/ja01472a033

文献信息

• Transition metal and base free synthesis of 2-aryl-2-oxazolines from aldehydes and β-amino alcohols catalysed by potassium iodide
  作者：C. Uma Maheswari、G. Sathish Kumar、M. Venkateshwar

  DOI：10.1039/c4ra08578g

  日期：——

  Synthesis of 2-aryl-2-oxazolines from β-amino alcohols and aldehydes was achieved in good to excellent yield by employing a potassium iodide (KI)–tert-butyl hydroperoxide (TBHP) catalytic system.

  通过使用碘化钾（KI）-叔丁基过氧化氢（TBHP）催化体系，从β-氨基醇和醛中合成2-芳基-2-噁唑酮可获得良好至优异的产率。
• The Isomerization and Dimerization of Aziridine Derivatives. IV
  作者：Harold W. Heine、William G. Kenyon、Eleanor M. Johnson

  DOI：10.1021/ja01472a033

  日期：1961.6
• Phosphine-Catalyzed Heine Reaction
  作者：Allen Martin、Kathleen Casto、William Morris、Jeremy B. Morgan

  DOI：10.1021/ol202410v

  日期：2011.10.21

  Aziridines are important synthetic Intermediates which readily undergo ring-opening reactions. It is demonstrated that electron-rich phosphines are efficient catalysts for the regioselective rearrangement of N-acylaziridines to oxazolines. The reactions occur in excellent yield under neutral conditions. Evidence is provided for an addition/elimination mechanism by generation of a phosphonium intermediate. Similar intermediates may be useful for the development of alternate aziridine ring-opening processes and stereoselective synthesis with enantiopure phosphines.