N,N'-Hexamethylenedihexamide | 21150-81-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N'-Hexamethylenedihexamide
• 英文别名: N,N'-hexanediyl-bis-hexanamide；N,N'-Hexandiyl-bis-hexanamid；N,N'-hexane-1,6-diyldihexanamide；Hexanamide, N,N'-1,6-hexanediylbis-；N-[6-(hexanoylamino)hexyl]hexanamide
• CAS: 21150-81-2
• 化学式: C₁₈H₃₆N₂O₂
• 分子量: 312.496
• InChiKey: FEEWLVLWKFQOFB-UHFFFAOYSA-N

物化性质

• 熔点：
  140-142 °C
• 沸点：
  527.9±33.0 °C(Predicted)
• 密度：
  0.925±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(5-cyano-pentyl)-hexanamide 在 1,4-二氧六环 、 吡啶 、 kieselguhr 、 氨 、 钴 作用下， 100.0 ℃ 、14.71 MPa 条件下， 生成 N,N'-Hexamethylenedihexamide
  参考文献：
  名称：

  Johnson, Journal of the Chemical Society

  摘要：

  DOI：

文献信息

• An efficient N-heterocyclic carbene based ruthenium-catalyst: Application towards the synthesis of esters and amides
  作者：Jagadeesh Malineni、Carina Merkens、Helmut Keul、Martin Möller

  DOI：10.1016/j.catcom.2013.06.002

  日期：2013.10

  ruthenium catalyst was prepared starting with readily accessible starting materials. Under inert gas atmosphere and in air the catalyst showed high activity for the direct synthesis of esters from primary alcohols and of amides from primary alcohols and amines. Di-, tri-, and oligo-amides were obtained by using specific starting materials.

  从易于获得的起始原料开始，制备了高度稳定的基于苯并咪唑基亚烷基的N-杂环卡宾（NHC）钌催化剂。在惰性气体气氛下和空气中，该催化剂对由伯醇直接合成酯以及由伯醇和胺直接合成酰胺具有很高的活性。通过使用特定的起始原料可得到二酰胺，三酰胺和寡酰胺。
• PROCESS FOR PREPARING AMIDES FROM ALCOHOLS AND AMINES
  申请人：MILSTEIN David

  公开号：US20090112005A1

  公开（公告）日：2009-04-30

  The present invention provides a process for preparing amides, by reacting a primary amine and a primary alcohol in the presence of a Ruthenium catalyst, to generate the amide and molecular hydrogen. According to the process of the invention, primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. This reaction is catalyzed by a Ruthenium complex, which is preferably based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3. Use of diamines in the reaction leads to bis-amides, whereas with a mixed primary/secondary amine substrate, chemoselective acylation of the primary amine group occurs.

  本发明提供了一种制备酰胺的方法，通过在Ruthenium催化剂的存在下反应一种一级胺和一种一级醇，生成酰胺和分子氢。根据本发明的方法，一级胺通过等摩尔量的醇直接酰化产生酰胺和分子氢（唯一的副产物），产率高，周转数高。这种反应由Ruthenium配合物催化，最好是基于公式A1的去芳香PNN型配体或其前体公式A2或A3。在反应中使用二胺会导致双酰胺，而使用混合的一级/二级胺底物，会发生一级胺基的化学选择性酰化。
• USE OF RUTHENIUM COMPLEXES FOR FORMATION AND/OR HYDROGENATION OF AMIDES AND RELATED CARBOXYLIC ACID DERIVATIVES
  申请人：Milstein David

  公开号：US20120253042A1

  公开（公告）日：2012-10-04

  A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular hydrogen. Primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. Also disclosed are processes for hydrogenation of amides to alcohols and amines; hydrogenation of organic carbonates to alcohols; hydrogenation of carbamates or urea derivatives to alcohols and amines; amidation of esters; acylation of alcohols using esters; coupling of alcohols with water and a base to form carboxylic acids; dehydrogenation of beta-amino alcohols to form pyrazines and cyclic dipeptides; and dehydrogenation of secondary alcohols to ketones. These reactions are catalyzed by a Ruthenium complex which is based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3.

  一种制备酰胺的方法，包括在Ruthenium配合物的存在下，通过反应一种一级胺和一种一级醇生成酰胺和分子氢。直接用等摩尔量的醇对一级胺进行酰化反应，可以高产率、高周转数地生成酰胺和分子氢（唯一的副产物）。此外，还揭示了将酰胺氢化为醇和胺的方法；将有机碳酸酯氢化为醇的方法；将氨基甲酸酯或尿素衍生物氢化为醇和胺的方法；酯的酰胺化反应；使用酯对醇进行酰化反应；将醇与水和碱偶联形成羧酸；将β-氨基醇脱氢生成吡嗪和环肽；以及将二级醇脱氢生成酮的方法。这些反应由基于A1式或A2式或A3式的去芳香的PNN型配体的Ruthenium配合物催化。
• ACRYLIC POLYMER COMPOSITION
  申请人：Zeon Corporation

  公开号：EP3438195A1

  公开（公告）日：2019-02-06

  Provided is an acrylic polymer composition comprising an acrylic polymer and a polyfunctional organic compound having an amide group, wherein the cross-linkable acrylic polymer composition has less than 50% decrease in molecular weight of the acrylic polymer when heated under conditions of 190°C and 144 hours in air.

  本发明提供了一种丙烯酸聚合物组合物，该组合物由丙烯酸聚合物和具有酰胺基团的多官能团有机化合物组成，其中可交联丙烯酸聚合物组合物在 190°C 和 144 小时的空气中加热时，丙烯酸聚合物的分子量降幅小于 50%。
• US4221703A
  申请人：——

  公开号：US4221703A

  公开（公告）日：1980-09-09