(R)-2-(6-(benzylamino)-9-methyl-9H-purin-2-ylamino)butan-1-ol | 288305-89-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (R)-2-(6-(benzylamino)-9-methyl-9H-purin-2-ylamino)butan-1-ol
• 英文别名: (R)-2-(6-(Benzylamino)-9-methyl-9H-purin-2-ylamino)butan-1-ol；(2R)-2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]butan-1-ol
• CAS: 288305-89-5
• 化学式: C₁₇H₂₂N₆O
• 分子量: 326.401
• InChiKey: JZNKOXKLAMPREP-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  87.9
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,6-二氯嘌呤 在 potassium carbonate 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 、 正丁醇 为溶剂， 反应 20.5h， 生成 (R)-2-(6-(benzylamino)-9-methyl-9H-purin-2-ylamino)butan-1-ol
  参考文献：
  名称：

  [EN] CALCIUM CHANNEL AGONISTS
  [FR] AGONISTES DE CANAUX CALCIQUES

  摘要：

  披露了钙通道激动剂的实施方式，以及制备和使用钙通道激动剂的方法。披露的钙通道激动剂及其相应的盐形式具有如下通用式I所示的结构，其中每个表示为“ ”的键是为了满足化合价要求而需要的单键或双键；Z1、Z2、Z3、Z4和Z5独立地是氮或碳；R1和R3是烷基；R2是烷基、芳基、杂环芳基、芳基烷基或杂环芳基烷基；而R4是烷基或羟基烷基。

  公开号：

  WO2014189830A1

文献信息

• [EN] CALCIUM CHANNEL AGONISTS<br/>[FR] AGONISTES DE CANAUX CALCIQUES
  申请人：UNIV PITTSBURGH

  公开号：WO2014189830A1

  公开（公告）日：2014-11-27

  Embodiments of calcium channel agonists, as well as methods of making and using the calcium channel agonists, are disclosed. The disclosed calcium channel agonists and corresponding salt forms have a structure according to general formula I wherein each bond depicted as " " is a single bond or a double bond as needed to satisfy valence requirements; Z1, Z2, Z3, Z4, and Z5 independently are nitrogen or carbon; R1 and R3 are alkyl; R2 is alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; and R4 is alkyl or hydroxyalkyl.

  披露了钙通道激动剂的实施方式，以及制备和使用钙通道激动剂的方法。披露的钙通道激动剂及其相应的盐形式具有如下通用式I所示的结构，其中每个表示为“ ”的键是为了满足化合价要求而需要的单键或双键；Z1、Z2、Z3、Z4和Z5独立地是氮或碳；R1和R3是烷基；R2是烷基、芳基、杂环芳基、芳基烷基或杂环芳基烷基；而R4是烷基或羟基烷基。
• [EN] IMAGING AGENTS FOR NEURAL FLUX<br/>[FR] AGENTS D'IMAGERIE POUR FLUX NEURONAL
  申请人：GEN HOSPITAL CORP

  公开号：WO2016011394A1

  公开（公告）日：2016-01-21

  Provided herein are radiolabeled compounds useful for non-invasive imaging techniques. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography. The present application also provides unlabeled compounds useful in methods of treating diseases of the central nervous system or disease of the peripheral nervous system. Methods for preparing radiolabeled compounds, preparing unlabeled compounds, and diagnostic methods using labeled or unlabeled compounds are also provided.

  本文提供了用于非侵入性成像技术的放射性标记化合物。本文提供的一种示例性放射性标记化合物可用作正电子发射断层扫描的放射示踪剂。本申请还提供了用于治疗中枢神经系统疾病或外周神经系统疾病的未标记化合物。还提供了制备放射性标记化合物、制备未标记化合物以及使用标记化或未标记化化合物的诊断方法。
• CALCIUM CHANNEL AGONISTS
  申请人：WIPF Peter

  公开号：US20160090387A1

  公开（公告）日：2016-03-31

  Embodiments of calcium channel agonists, as well as methods of making and using the calcium channel agonists, are disclosed. The disclosed calcium channel agonists and corresponding salt forms have a structure according to general formula I: wherein each bond depicted as “ ” is a single bond or a double bond as needed to satisfy valence requirements; Z 1 , Z 2 , Z 3 , Z 4 , and Z 5 independently are nitrogen or carbon; R 1 and R 3 are alkyl; R 2 is alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; and R 4 is alkyl or hydroxyalkyl.

  本发明揭示了钙通道激动剂的实施方式，以及制备和使用钙通道激动剂的方法。所述的钙通道激动剂和相应的盐形式具有通式I的结构：其中，每个表示为“”的键是单键或双键，以满足价键要求；Z1、Z2、Z3、Z4和Z5独立地为氮或碳；R1和R3为烷基；R2为烷基、芳基、杂芳基、芳基烷基或杂芳基烷基；R4为烷基或羟基烷基。
• Calcium channel agonists
  申请人：University of Pittsburgh—Of the Commonwealth System of Higher Education

  公开号：US10174031B2

  公开（公告）日：2019-01-08

  Embodiments of calcium channel agonists, as well as methods of making and using the calcium channel agonists, are disclosed. The disclosed calcium channel agonists and corresponding salt forms have a structure according to general formula I: wherein each bond depicted as “” is a single bond or a double bond as needed to satisfy valence requirements; Z1, Z2, Z3, Z4, and Z5 independently are nitrogen or carbon; R1 and R3 are alkyl; R2 is alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; and R4 is alkyl or hydroxyalkyl.

  本发明公开了钙通道激动剂的实施方案以及钙通道激动剂的制造和使用方法。所公开的钙通道激动剂和相应的盐形式具有通式 I 的结构： 其中描述为""的每个键是单键或双键，以满足化合价要求；Z1、Z2、Z3、Z4 和 Z5 独立地为氮或碳；R1 和 R3 为烷基；R2 为烷基、芳基、杂芳基、芳烷基或杂芳基烷基；R4 为烷基或羟烷基。
• Imaging agents for neural flux
  申请人：The General Hospital Corporation

  公开号：US10519160B2

  公开（公告）日：2019-12-31

  Provided herein are radiolabeled compounds useful for non-invasive imaging techniques. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography. The present application also provides unlabeled compounds useful in methods of treating diseases of the central nervous system or disease of the peripheral nervous system. Methods for preparing radiolabeled compounds, preparing unlabeled compounds, and diagnostic methods using labeled or unlabeled compounds are also provided.

  本文提供的放射性标记化合物可用于非侵入性成像技术。本文提供的一种示例性放射性标记化合物可用作正电子发射断层扫描的放射性示踪剂。本申请还提供了用于治疗中枢神经系统疾病或周围神经系统疾病的未标记化合物。还提供了制备放射性标记化合物、制备未标记化合物的方法，以及使用标记或未标记化合物的诊断方法。