N-Phenaethyl-crotonamid | 100389-80-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-Phenaethyl-crotonamid
• 英文别名: N-(2-phenylethyl)but-2-enamide
• CAS: 100389-80-8
• 化学式: C₁₂H₁₅NO
• mdl: MFCD00540810
• 分子量: 189.257
• InChiKey: KABVDEVMZWSSRL-UHFFFAOYSA-N

物化性质

• 沸点：
  376.7±25.0 °C(Predicted)
• 密度：
  1.007±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  巴豆酸 、 2-苯乙胺 在 4,6-dichloro-1,3,5-triazin-2-yl-NH-PEG-polystyrene 作用下， 生成 N-Phenaethyl-crotonamid
  参考文献：
  名称：

  Solid-Supported Chloro[1,3,5]triazine. A Versatile New Synthetic Auxiliary for the Synthesis of Amide Libraries

  摘要：

  [GRAPHICS]2,4,6-Trichloro[1,3,5]triazine was loaded on different types of NH2-functional resins to give a new supported reagent. The best results, in term of yields products, were obtained using the chlorotriazine linked to a polystyrene-poly(ethylene glycol) resin. This reagent was employed for the solution-phase synthesis of different amides and dipeptides.

  DOI：

  10.1021/ol990215h

文献信息

• US4591597A
  申请人：——

  公开号：US4591597A

  公开（公告）日：1986-05-27
• Solid-Supported Chloro[1,3,5]triazine. A Versatile New Synthetic Auxiliary for the Synthesis of Amide Libraries
  作者：Simonetta Masala、Maurizio Taddei

  DOI：10.1021/ol990215h

  日期：1999.11.1

  [GRAPHICS]2,4,6-Trichloro[1,3,5]triazine was loaded on different types of NH2-functional resins to give a new supported reagent. The best results, in term of yields products, were obtained using the chlorotriazine linked to a polystyrene-poly(ethylene glycol) resin. This reagent was employed for the solution-phase synthesis of different amides and dipeptides.