1-cyclohexyl-3,4-dimethyl-1H-pyrrole-2,5-dione | 74190-55-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-cyclohexyl-3,4-dimethyl-1H-pyrrole-2,5-dione
• 英文别名: 1-cyclohexyl-3,4-dimethylpyrrole-2,5-dione
• CAS: 74190-55-9
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: HYEFSQVPFYQDCW-UHFFFAOYSA-N

物化性质

• 沸点：
  318.7±11.0 °C(Predicted)
• 密度：
  1.137±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-cyclohexyl-3,4-dimethyl-1H-pyrrole-2,5-dione 、 甲基锂 以97%的产率得到1-cyclohexyl-5-hydroxy-3,4,5-trimethyl-1,5-dihydro-2H-pyrrol-2-one
  参考文献：
  名称：

  Synthesis of potent neuroprotective butenolides based on plant smoke derived 3,4,5-Trimethylfuran-2(5H)-one and 3-methyl-2H-furo[2,3-c]pyrone-2-one

  摘要：

  Smoke derived karrikinolide and trimethylbutenolide exerted neuroprotective effects against monoamine oxidase and acetylcholinesterase. Synthesis of potent analogs was achieved. Sulphur substitution in the bicyclic ring structure of KAR(1) displayed the most encouraging activity returning IC50 values of 13.75 +/- 0.001 mu M and 0.03 +/- 0.02 mu M for monoamine oxidase A and B and 0.08 +/- 0.006 mu M for acetylcholinesterase. Neuroprotective butenolides may be particularly useful in the treatment of depressive disorders, Alzheimer's and Parkinson's diseases.

  DOI：

  10.1016/j.phytochem.2019.03.014
• 作为产物：
  描述：

  2,3-二甲基马来酸酐 、 环己胺 以 四氢呋喃 为溶剂， 以71%的产率得到1-cyclohexyl-3,4-dimethyl-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  Synthesis of potent neuroprotective butenolides based on plant smoke derived 3,4,5-Trimethylfuran-2(5H)-one and 3-methyl-2H-furo[2,3-c]pyrone-2-one

  摘要：

  Smoke derived karrikinolide and trimethylbutenolide exerted neuroprotective effects against monoamine oxidase and acetylcholinesterase. Synthesis of potent analogs was achieved. Sulphur substitution in the bicyclic ring structure of KAR(1) displayed the most encouraging activity returning IC50 values of 13.75 +/- 0.001 mu M and 0.03 +/- 0.02 mu M for monoamine oxidase A and B and 0.08 +/- 0.006 mu M for acetylcholinesterase. Neuroprotective butenolides may be particularly useful in the treatment of depressive disorders, Alzheimer's and Parkinson's diseases.

  DOI：

  10.1016/j.phytochem.2019.03.014

文献信息

• Synthesis of New Diphosphine Ligands and their Application in Pd-Catalyzed Alkoxycarbonylation Reactions
  作者：Anahit Pews-Davtyan、Xianjie Fang、Ralf Jackstell、Anke Spannenberg、Wolfgang Baumann、Robert Franke、Matthias Beller

  DOI：10.1002/asia.201301636

  日期：2014.4

  Carbocyclic and N‐heterocyclic analogues of the industrially applied ligand bis(di‐tert‐butylphosphinomethyl)benzene (1) have been synthesized in moderate to very good yields. The new ligands are based on benzene, tetralin, lutidine, pyrazine, quinoxaline, and maleimide backbones. Electronic and steric variations of the phosphorous donor sites were performed. As a benchmark reaction, the palladium‐catalyzed

  工业应用的配体双（二叔丁基膦基甲基）苯（1）的碳环和N杂环类似物的合成产率中等至非常高。新的配体基于苯，四氢萘，二甲基吡啶，吡嗪，喹喔啉和马来酰亚胺骨架。进行了磷供体位点的电子和空间变化。作为基准反应，已经测试了钯催化的1-辛烯的甲氧基羰基化。酯产率高达64％，线性选择性高达92％。
• Methacrylic resin composition
  申请人：ASAHI KASEI KABUSHIKI KAISHA

  公开号：US10017627B1

  公开（公告）日：2018-07-10

  A methacrylic resin composition having high heat resistance, excellent birefringence, and excellent heat stability and molding processability is provided. A methacrylic resin composition comprises: a methacrylic resin including a structural unit (X) having a cyclic structure-containing main chain, the structural unit (X) being at least one type selected from the group consisting of an N-substituted maleimide monomer-derived structural unit, a glutarimide-based structural unit, and a lactone ring structural unit; and an organic phosphorous compound, wherein a glass transition temperature is more than 120° C. and 160° C. or less, a content of a phosphorus element is 10 mass ppm to 1000 mass ppm, and a ratio P3/P5 of an integral value P3 of a spectral peak assigned to trivalent phosphorus to an integral value P5 of a spectral peak assigned to pentavalent phosphorus in 31P-NMR measurement is 0.2 to 5.0.

  本发明提供了一种具有高耐热性、优异的双折射性、优异的热稳定性和成型加工性的甲基丙烯酸树脂组合物。一种甲基丙烯酸树脂组合物包括：一种甲基丙烯酸树脂，包括具有含环结构主链的结构单元 (X)，该结构单元 (X) 至少是从 N-取代马来酰亚胺单体衍生结构单元、戊二酰亚胺基结构单元和内酯环结构单元组成的组中选出的一种类型；以及一种有机磷化合物，其中玻璃化温度大于 120°C.在 31P-NMR 测量中，磷元素的含量为 10 质量ppm 至 1000 质量ppm，三价磷光谱峰积分值 P3 与五价磷光谱峰积分值 P5 之比 P3/P5 为 0.2 至 5.0。
• Acrylic thermoplastic resin composition and molded article thereof
  申请人：Yonemura Masami

  公开号：US10030134B2

  公开（公告）日：2018-07-24

  An acrylic thermoplastic resin composition includes a first acrylic resin having a first structural unit represented by the following formula (1) and a second structural unit represented by the following formula (2), and a second acrylic resin having the first structural unit represented by the following formula (1) and a third structural unit represented by the following formula (3), in which a total content of the first unit is 50 to 95 mass % and a total content of the second structural unit and the third structural unit is 5 to 50 mass % based on a total amount of the first acrylic resin and the second acrylic resin:

  一种丙烯酸热塑性树脂组合物包括具有下式（1）表示的第一结构单元和下式（2）表示的第二结构单元的第一丙烯酸树脂，以及具有下式（1）表示的第一结构单元和下式（3）表示的第三结构单元的第二丙烯酸树脂，其中基于第一丙烯酸树脂和第二丙烯酸树脂的总量，第一结构单元的总含量为 50 至 95 质量％，第二结构单元和第三结构单元的总含量为 5 至 50 质量％：
• Methacrylic resin and production method, molded article, and optical or automotive component of same
  申请人：ASAHI KASEI KABUSHIKI KAISHA

  公开号：US10800875B2

  公开（公告）日：2020-10-13

  Provided are a methacrylic resin having high heat resistance, highly controlled birefringence, and excellent color tone and transparency, and a production method, a molded article, and an optical or automotive component of the methacrylic resin. The methacrylic resin includes N-substituted maleimide monomer-derived structural units (B) in a main chain thereof in a proportion of 5 mass % to 40 mass %. The N-substituted maleimide monomer-derived structural units (B) include a structural unit represented by formula (1). The methacrylic resin has a glass transition temperature of higher than 120° C. and not higher than 160° C. The content of components that exhibit light absorption at a wavelength of 400 nm in methanol-soluble content of the methacrylic resin is more than 0 mass % and not more than 2 mass % as calculated in terms of N-phenylmaleimide.

  本发明提供了一种具有高耐热性、高度可控的双折射、优异的色调和透明度的甲基丙烯酸树脂，以及该甲基丙烯酸树脂的生产方法、成型品和光学或汽车零部件。该甲基丙烯酸树脂的主链中包含 N-取代马来酰亚胺单体衍生的结构单元（B），其比例为 5 质量％至 40 质量％。N-取代马来酰亚胺单体衍生结构单元（B）包括由式（1）表示的结构单元。甲基丙烯酸树脂的玻璃化温度高于 120℃，但不高于 160℃。以 N-苯基马来酰亚胺计，在甲基丙烯酸树脂的甲醇可溶物含量中，波长为 400 纳米的光吸收成分的含量高于 0 质量%，但不高于 2 质量%。
• EP2727961A1
  申请人：——

  公开号：EP2727961A1

  公开（公告）日：2014-05-07