bis(4-isopropylphenyl)phosphoryl chloride | 72121-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(4-isopropylphenyl)phosphoryl chloride
• 英文别名: Phosphorochloridic acid, bis((1-methylethyl)phenyl) ester；1-[chloro-(4-propan-2-ylphenoxy)phosphoryl]oxy-4-propan-2-ylbenzene
• CAS: 72121-76-7
• 化学式: C₁₈H₂₂ClO₃P
• 分子量: 352.798
• InChiKey: KYNLYVFUBUCGTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  bis(4-isopropylphenyl)phosphoryl chloride 、 isobu-OH 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以56%的产率得到bis(4-propan-2-ylphenyl) [3-[(1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]-2-[[(1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]methyl]propyl] phosphate
  参考文献：
  名称：

  Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure–activity study

  摘要：

  We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.04.027
• 作为产物：
  描述：

  4-异丙基苯酚 在 aluminum (III) chloride 、 三氯氧磷 作用下， 反应 1.0h， 生成 bis(4-isopropylphenyl)phosphoryl chloride
  参考文献：
  名称：

  Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure–activity study

  摘要：

  We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.04.027

文献信息

• Peroxygen bleaching and compositions therefor
  申请人：FMC Corporation

  公开号：US04212757A1

  公开（公告）日：1980-07-15

  A process of removing soil and/or stains from fabrics by immersing the fabrics in a peroxygen bleach bath containing as a peroxygen activator an organophosphorus chlorine compound selected from the class consisting of R.sub.1 OR.sub.2 OP(O)Cl, R.sub.1 R.sub.2 OP(O)Cl and R.sub.1 R.sub.2 P(O)Cl, wherein R.sub.1 and R.sub.2 represent the organic portion of the molecule.

  将织物浸泡在过氧化物漂白浴中，其中包含有机磷氯化合物作为过氧化物活化剂，所述有机磷氯化合物选择自R.sub.1 OR.sub.2 OP(O)Cl、R.sub.1 R.sub.2 OP(O)Cl和R.sub.1 R.sub.2 P(O)Cl等类别，以去除织物上的土壤和/或污渍。其中R.sub.1和R.sub.2代表分子的有机部分。
• ANTI-CYTOMEGALOVIRUS ACTIVITY OF ARTEMISININ-DERIVED DIMERS
  申请人：Arav-Boger Ravit

  公开号：US20130109654A1

  公开（公告）日：2013-05-02

  Artemisinin-derived monomers and artemisinin dimers are shown to exhibit in-vitro anti-cytomegalovirus (CMV) activity. Artemisinin dimers effectively inhibited CMV replication in human foreskin fibroblasts and human embryonic lung fibroblasts with no cytotoxicity at concentrations required for complete CMV inhibition. Artemisinin dimers were found to be potent and non-cytotoxic inhibitors of CMV replication, which indicates their use as therapeutic agents for the treatment of CMV infection in humans.

  青蒿素衍生单体和青蒿素二聚体表现出体外抗巨细胞病毒（CMV）活性。青蒿素二聚体有效抑制了人阴茎包皮纤维细胞和人胚肺纤维细胞中的CMV复制，且在完全抑制CMV所需的浓度下无细胞毒性。青蒿素二聚体被发现是强效且无细胞毒性的CMV复制抑制剂，这表明它们可用作治疗人类CMV感染的治疗剂。
• Single-functional and mixtures of multifunctional oligomeric performance additive compositions, and their use
  申请人：ELF ATOCHEM NORTH AMERICA, INC.

  公开号：EP0332761A2

  公开（公告）日：1989-09-20

  The present invention comprises novel single-functional and mixtures of multi-functional oligomeric performance additive compounds having one or more components of Structure A (The definitions of R, Z1, Z2, Z3, A1, A2, A3 and y are given in the Summary Section), their uses and polymeric compounds and compositions containing them which have enhanced oxidative stabilities, enhanced ultraviolet (UV) and light stabilities and/or enhanced flame retardance. An example is the bis sulfonic acid bispotassium salt reaction product from an oligomeric caprolactone diol (TONE® 260), 2-sulfobenzoic acid anhydride and potassium carbonate, and use of this product, at levels up to about 3.0%, in a general purpose bisphenol A polycarbonate resin, to enhance the fire resistance or flame retardance of the polycarbonate resin.

  本发明包括具有一种或多种结构 A 组分的新型单官能团和多官能团低聚物性能添加剂混合物 （R、Z1、Z2、Z3、A1、A2、A3 和 y 的定义见摘要部分）、它们的用途以及含有它们的聚合物化合物和组合物。 (R、Z1、Z2、Z3、A1、A2、A3 和 y 的定义见摘要部分）、它们的用途以及含有它们的聚合物化合物和组合物，它们具有增强的氧化稳定性、增强的紫外线（UV）和光稳定性和/或增强的阻燃性。例如，低聚己内酯二醇（TONE® 260）、2-磺酸基苯甲酸酐和碳酸钾的双磺酸双钾盐反应产物，以及在通用双酚 A 型聚碳酸酯树脂中使用该产物（含量最高约为 3.0%），可增强聚碳酸酯树脂的耐火性或阻燃性。
• Flame retardant, additive compositions, and flame retardant polyurethanes
  申请人：Hussain Saadat

  公开号：US20050113495A1

  公开（公告）日：2005-05-26

  Provided are new flame retardants and liquid flame retardant additive compositions of low viscosity for use in flexible polyurethane foams. The new flame retardants are the reaction product of at least one brominated aromatic diester diol with at least one alcohol-reactive agent. Preferred liquid flame retardant additive compositions are capable of minimizing visible scorching of the foam during its production. Flexible flame retardant polyurethane foams and methods for their production are also provided. The flame retardant additive compositions are formed at least from a) at least one reaction product of a brominated aromatic diester diol and an alcohol-reactive agent; b) at least one hindered amine antioxidant; and c) at least one phenolic antioxidant in which the phenolic ring is substituted by an alkanoic acid alkyl ester group in which alkanoic acid moiety has in the range of 2 to about 4 carbon atoms and the alkyl group has in the range of about 6 to about 16 carbon atoms.

  本文提供了用于软质聚氨酯泡沫的新型阻燃剂和低粘度液体阻燃添加剂组合物。新型阻燃剂是至少一种溴化芳香族二酯二醇与至少一种醇反应剂的反应产物。优选的液态阻燃添加剂组合物能够在泡沫生产过程中最大限度地减少可见的焦烧现象。此外，还提供了柔性阻燃聚氨酯泡沫及其生产方法。阻燃添加剂组合物至少由以下物质形成：a) 至少一种溴化芳香族二酯二元醇与醇反应剂的反应产物；b) 至少一种受阻胺抗氧化剂；c) 至少一种酚类抗氧化剂，其中酚环被烷酸烷基酯基团取代，烷酸分子的碳原子数在 2 至约 4 之间，烷基的碳原子数在约 6 至约 16 之间。
• Magura, Miroslav; Vojtko, Jan; Ilavsky, Jan, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 5, p. 1311 - 1317
  作者：Magura, Miroslav、Vojtko, Jan、Ilavsky, Jan

  DOI：——

  日期：——