N-Ethyl-2,6-dibrom-4-nitroanilin | 98545-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Ethyl-2,6-dibrom-4-nitroanilin
• 英文别名: N-ethyl-2,6-dibromo-4-nitro-aniline；N-Aethyl-2,6-dibrom-4-nitro-anilin；2,6-dibromo-N-ethyl-4-nitroaniline
• CAS: 98545-76-7
• 化学式: C₈H₈Br₂N₂O₂
• 分子量: 323.972
• InChiKey: OESYABTXEUHIST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-乙基-对-硝基苯胺 在 溴 、 溶剂黄146 作用下， 生成 N-Ethyl-2,6-dibrom-4-nitroanilin
  参考文献：
  名称：

  Kharasch; Jacobson, Journal of the American Chemical Society, 1921, vol. 43, p. 1903

  摘要：

  DOI：

文献信息

• A Proteomic Approach to the Identification of Lung Cancer Markers
  作者：Samir Hanash、Franck Brichory、David Beer

  DOI：10.1155/2001/657605

  日期：——

  We have developed a comprehensive approach to the identification of protein markers in lung cancer that includes profiling of tumor tissue and cell lines as well as the analysis of serum for autoantibodies to lung tumor antigens. A large number of proteins that are differentially expressed in the major subtypes of lung cancer have been identified by mass spectrometry. A database of protein expression in lung cancer and other types of cancer has been constructed that integrates two-dimensional gel profiles, mass spectrometry data, quantitative protein data and gene expression data at the RNA level, that serves as a resource for biomarker identification. Analysis of the serological response in lung cancer has led to the identification of novel markers detectable in serum of lung cancer patients at the time of diagnosis. The proteomic approach is likely to yield novel classification schemes and novel markers for early diagnosis of lung cancer.

  我们已经开发了一种全面的方法来识别肺癌中的蛋白标记物，包括肿瘤组织和细胞系的分析，以及血清中自身抗体对肺肿瘤抗原的分析。通过质谱法已经鉴定了在肺癌主要亚型中差异表达的大量蛋白质。已构建了一个蛋白质在肺癌和其他类型癌症中的表达数据库，集成了二维凝胶轮廓、质谱数据、定量蛋白数据和RNA水平的基因表达数据，作为生物标志物识别的资源。对肺癌患者血清中的免疫反应进行分析，已经发现了在诊断时可在肺癌患者血清中检测到的新标记物。蛋白质组学方法可能会产生新的分类方案和早期诊断肺癌的新标记物。
• Kharasch; Jacobson, Journal of the American Chemical Society, 1921, vol. 43, p. 1903
  作者：Kharasch、Jacobson

  DOI：——

  日期：——